MG-132
- CAS No.
- 133407-82-6
- Chemical Name:
- MG-132
- Synonyms
- CS-216;MG-132;Z-LL-CHO;Z-LLL-al;Z-LLL-CHO;(S)-MG132;MG-132(SSS);MG132/MG-132;MG-132, >=98%;Z-LEU-LEU-LEU-H
- CBNumber:
- CB3298042
- Molecular Formula:
- C26H41N3O5
- Molecular Weight:
- 475.62
- MDL Number:
- MFCD00674886
- MOL File:
- 133407-82-6.mol
- MSDS File:
- SDS
Melting point | 80-84℃ (DEC.) |
---|---|
alpha | -61~-67° |
Boiling point | 682.0±55.0 °C(Predicted) |
Density | 1.073 |
Flash point | 366℃ |
storage temp. | -20°C |
solubility | methanol: 1 mg/mL |
form | solid film |
pka | 11.14±0.46(Predicted) |
color | White |
Water Solubility | Soluble in ethanol, chloroform, methanol, water. |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20° for up to 1 week. |
InChIKey | TZYWCYJVHRLUCT-VABKMULXSA-N |
FDA UNII | RF1P63GW3K |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319-H335 |
Precautionary statements | P271-P280 |
Risk Statements | 36/37/38 |
Safety Statements | 24/25 |
WGK Germany | 3 |
HS Code | 29242990 |
MG-132 price More Price(58)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 474790 | MG-132 A cell-permeable, potent, reversible proteasome inhibitor (K | 133407-82-6 | 1mg | $56.2 | 2024-03-01 | Buy |
Sigma-Aldrich | 474787 | MG-132, ≥95% by HPLC | 133407-82-6 | 10mg | $85.2 | 2024-03-01 | Buy |
Alfa Aesar | J63250 | MG 132 | 133407-82-6 | 1mg | $35.4 | 2023-06-20 | Buy |
Alfa Aesar | J63250 | MG 132 | 133407-82-6 | 5mg | $134 | 2023-06-20 | Buy |
Cayman Chemical | 10012628 | (S)-MG132 ≥98% | 133407-82-6 | 1mg | $20 | 2024-03-01 | Buy |
MG-132 Chemical Properties,Uses,Production
Description
MG-132 (133407-82-6) is a specific inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50=100 nM with Z-LLL-AMC as substrate).1 Also inhibits calpain (IC50=1.25 μM).1 Suppresses gastric cancer cell proliferation and induces macro-autophagy.2 Activates stress kinases and induces Hsp72.3 Induces neurite outgrowth.1 MG-132 blocks NFκB activation by blocking IκB proteolysis (IC50=3 μM).4 Cell permeable.
Uses
MG 132 is a potent, membrane-permeable proteasome inhibitor. It induces neurite outgrowth in PC12 cells. Neuroprotective product.
Uses
A proteasome and NF-κB inhibitor.
Definition
ChEBI: A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.
General Description
Potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) and inhibits NF-κB activation (IC50 = 3 μM).
Biological Activity
Potent cell-permeable inhibitor of proteasome (IC 50 = 100 nM) and calpain (IC 50 = 1.2 μ M). Inhibits TNF- α -induced NF- κ B activation and I κ B α degradation. Induces neurite outgrowth in PC12 cells and has anticancer properties in vitro .
Biochem/physiol Actions
Cell permeable: yes
storage
-20°C (desiccate)
References
1) Tsubuki et al. (1996), Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine; J. Biochem.,? 119 572 2) Wu? et al. (2010), Macroautophagy and ERK phosphorylation counteract the antiproliferative effect of proteasome inhibitor in gastric cancer cells; Autophagy, 6 228 3) Meriin? et al. (1998), Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis; J. Biol. Chem., 273 6373 4) Fiedler et al. (1998), Inhibition of TNF-alpha-induced NF-kappaB activation and IL-8 release in A549 cells with the proteasome inhibitor MG-132; Am. J. Respir. Cell Mol. Biol., 19 259
MG-132 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Alpha Biopharmaceuticals Co., Ltd | +86-15542445688 | sales@alabiochem.com | China | 888 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10311 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29824 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5873 | 58 |
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