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ChemicalBook >> CAS DataBase List >>1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide

1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide

1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide Structure
1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide structure
CAS No.
1012104-68-5
Chemical Name:
1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide
Synonyms
IRAK inhibitor 4;1H-BenziMidazole-5-carboxaMide, 1-(4-hydroxycyclohexyl)-N-(3-Methylbutyl)-2-[[5-[2-(trifluoroMethoxy)phenyl]-1H-indazol-3-yl]aMino]-;1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide;1-((1R, 4R)-4-Hydroxycyclohexyl)-N-isopentyl-2-(5-(2-(trifluoromethoxy)phenyl)-1H-indazol-3-ylamino)-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide
CBNumber:
CB72604243
Molecular Formula:
C33H35F3N6O3
Molecular Weight:
620.66
MDL Number:
MFCD22124483
MOL File:
1012104-68-5.mol
MSDS File:
SDS
Last updated:2025-12-10 09:00:29
Product description Number Pack Size Price
IRAKinhibitor4 A3503 2mg $704
IRAKinhibitor4 99.77% CS-0606 5mg $804
1-((1R,4R)-4-HYDROXYCYCLOHEXYL)-N-ISOPENTYL-2-(5-(2-(TRIFLUOROMETHOXY)PHENYL)-1H-INDAZOL-3-YLAMINO)-1H-BENZIMIDAZOLE-5-CARBOXYLIC ACID (3-METHYLBUTYL)AMIDE 95.00% KIN0001409 5MG $1162.7
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1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide Properties

Density 1.41
storage temp. Store at -20°C
solubility Soluble in DMSO
form Powder
pka 13.54±0.40(Predicted)
color Off-white to light brown

1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ApexBio Technology A3503 IRAKinhibitor4 1012104-68-5 2mg $704 2021-12-16 Buy
ChemScene CS-0606 IRAKinhibitor4 99.77% 1012104-68-5 5mg $804 2021-12-16 Buy
American Custom Chemicals Corporation KIN0001409 1-((1R,4R)-4-HYDROXYCYCLOHEXYL)-N-ISOPENTYL-2-(5-(2-(TRIFLUOROMETHOXY)PHENYL)-1H-INDAZOL-3-YLAMINO)-1H-BENZIMIDAZOLE-5-CARBOXYLIC ACID (3-METHYLBUTYL)AMIDE 95.00% 1012104-68-5 5MG $1162.7 2021-12-16 Buy
Product number Packaging Price Buy
A3503 2mg $704 Buy
CS-0606 5mg $804 Buy
KIN0001409 5MG $1162.7 Buy

1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide Chemical Properties,Uses,Production

Uses

IRAK inhibitor 4 is an interleukin-1 receptor associated kinase 4(IRAK4) inhibitor.

Biological Activity

irak inhibitor 4 is an inhibitor of interleukin- 1 receptor-associated kinase [1].irak-4 belongs to interleukin-1 receptor-associated kinase, which are key components in the signal transduction pathways. irak-4 is an essential signal transducer downstream of interleukin-1 receptor (il-1r), interleukin-18 receptor (il-18r) and toll-like receptors (tlrs). inhibition of irak-4 can modulate its function, thus toning down inflammatory responses. irak inhibitor 4 is an indazole inhibitor. as inhibitors of irak-4, imidazo[1,2-b]pyridazines and indazoles are used for treatment of some inflammatory, cell proliferative and immune-related disorders [1].

in vivo

IRAK-4-/-?mice exhibit a greatly reduced survival rate following aerosol infection compared with IRAK-4+/+?or IRAK-4+/-?mice. IRAK-4-/- mice show increased bacterial burden in all organs at 15, 30, and 60 d postinfection[1]. MCL1, but not BCL-xL, overrides the therapeutic effects of combinatorial IRAK1/4 inhibitor and ABT-737 therapy in vivo[3].

target

IRAK

IC 50

IRAK4

References

[1] zhulun wang, holger wesche, tracey stevens, nigel walker and wen-chen yeh. irak-4 inhibitors for inflammation. current topics in medicinal chemistry. 2009, 9: 724-737.

1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide Preparation Products And Raw materials

Raw materials

Preparation Products

1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide Suppliers

Global( 32)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32435 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39035 58
Aladdin Scientific 		tp@aladdinsci.com United States 52923 58
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19961 58
Chembest Research Laboratories Limited +86-21-20908456 sales@BioChemBest.com China 6003 61
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7552 61
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2384 58
SPIRO PHARMA eric_feng1954@126.com China 9248 55
BOC Sciences 16314854226 info@bocsci.com United States 9923 65
Supplier Advantage
TargetMol Chemicals Inc. 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
TargetMol Chemicals Inc. 		58
Chembest Research Laboratories Limited 61
Haoyuan Chemexpress Co., Ltd. 61
LETOPHARM LIMITED 58
SPIRO PHARMA 55
BOC Sciences 65

View Lastest Price from 1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
IRAK inhibitor 4 pictures 2025-12-09 IRAK inhibitor 4
1012104-68-5
 US $2500.00-1520.00 / mg 10g TargetMol Chemicals Inc.
IRAK inhibitor 4 pictures 2025-08-22 IRAK inhibitor 4
1012104-68-5
 US $2500.00-1520.00 / mg 10g TargetMol Chemicals Inc.
1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide IRAK inhibitor 4 1H-BenziMidazole-5-carboxaMide, 1-(4-hydroxycyclohexyl)-N-(3-Methylbutyl)-2-[[5-[2-(trifluoroMethoxy)phenyl]-1H-indazol-3-yl]aMino]- 1-((1R, 4R)-4-Hydroxycyclohexyl)-N-isopentyl-2-(5-(2-(trifluoromethoxy)phenyl)-1H-indazol-3-ylamino)-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide 1012104-68-5 C33H35F3N6O3