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ChemicalBook >> CAS DataBase List >>1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide

1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide

1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide Structure
1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide structure
CAS No.
1012104-68-5
Chemical Name:
1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide
Synonyms
IRAK inhibitor 4;1H-BenziMidazole-5-carboxaMide, 1-(4-hydroxycyclohexyl)-N-(3-Methylbutyl)-2-[[5-[2-(trifluoroMethoxy)phenyl]-1H-indazol-3-yl]aMino]-;1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide;1-((1R, 4R)-4-Hydroxycyclohexyl)-N-isopentyl-2-(5-(2-(trifluoromethoxy)phenyl)-1H-indazol-3-ylamino)-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide
CBNumber:
CB72604243
Molecular Formula:
C33H35F3N6O3
Molecular Weight:
620.66
MDL Number:
MFCD22124483
MOL File:
1012104-68-5.mol
MSDS File:
SDS
Last updated:2023-05-21 10:59:17
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1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide Properties

Density 1.41
storage temp. Store at -20°C
solubility Soluble in DMSO
form Powder
pka 13.54±0.40(Predicted)

1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ApexBio Technology A3503 IRAKinhibitor4 1012104-68-5 2mg $704 2021-12-16 Buy
ChemScene CS-0606 IRAKinhibitor4 99.77% 1012104-68-5 5mg $804 2021-12-16 Buy
American Custom Chemicals Corporation KIN0001409 1-((1R,4R)-4-HYDROXYCYCLOHEXYL)-N-ISOPENTYL-2-(5-(2-(TRIFLUOROMETHOXY)PHENYL)-1H-INDAZOL-3-YLAMINO)-1H-BENZIMIDAZOLE-5-CARBOXYLIC ACID (3-METHYLBUTYL)AMIDE 95.00% 1012104-68-5 5MG $1162.7 2021-12-16 Buy
Product number Packaging Price Buy
A3503 2mg $704 Buy
CS-0606 5mg $804 Buy
KIN0001409 5MG $1162.7 Buy

1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide Chemical Properties,Uses,Production

Biological Activity

irak inhibitor 4 is an inhibitor of interleukin- 1 receptor-associated kinase [1].irak-4 belongs to interleukin-1 receptor-associated kinase, which are key components in the signal transduction pathways. irak-4 is an essential signal transducer downstream of interleukin-1 receptor (il-1r), interleukin-18 receptor (il-18r) and toll-like receptors (tlrs). inhibition of irak-4 can modulate its function, thus toning down inflammatory responses. irak inhibitor 4 is an indazole inhibitor. as inhibitors of irak-4, imidazo[1,2-b]pyridazines and indazoles are used for treatment of some inflammatory, cell proliferative and immune-related disorders [1].

target

IRAK

References

[1] zhulun wang, holger wesche, tracey stevens, nigel walker and wen-chen yeh. irak-4 inhibitors for inflammation. current topics in medicinal chemistry. 2009, 9: 724-737.

1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide Preparation Products And Raw materials

Raw materials

Preparation Products

1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide Suppliers

Global( 26)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 6009 61
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7553 61
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2384 58
SPIRO PHARMA eric_feng1954@126.com China 9254 55
BOC Sciences 16314854226 info@bocsci.com United States 9926 65
Guangzhou QiYun Biotechnology Co., Ltd. 020-61288194 61288195 505721671@qq.com China 3868 58
Musechem +1-800-259-7612 info@musechem.com United States 4662 60
Supplier Advantage
TargetMol Chemicals Inc. 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
Aladdin Scientific 		58
Chembest Research Laboratories Limited 61
Haoyuan Chemexpress Co., Ltd. 61
LETOPHARM LIMITED 58
SPIRO PHARMA 55
BOC Sciences 65
Guangzhou QiYun Biotechnology Co., Ltd. 58
Musechem 60
1-(4-Hydroxycyclohexyl)-2-[[5-(2-trifluoromethoxyphenyl)-1H-indazol-3-yl]amino]-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide IRAK inhibitor 4 1H-BenziMidazole-5-carboxaMide, 1-(4-hydroxycyclohexyl)-N-(3-Methylbutyl)-2-[[5-[2-(trifluoroMethoxy)phenyl]-1H-indazol-3-yl]aMino]- 1-((1R, 4R)-4-Hydroxycyclohexyl)-N-isopentyl-2-(5-(2-(trifluoromethoxy)phenyl)-1H-indazol-3-ylamino)-1H-benzimidazole-5-carboxylic acid (3-methylbutyl)amide 1012104-68-5 C33H35F3N6O3