pilaralisib
- CAS No.
- 934526-89-3
- Chemical Name:
- pilaralisib
- Synonyms
- CS-1670;pilaralisib;XL147(pilaralisib);Pilaralisib (XL-147);XL-147(Pilaralisib) (new);XL-147,Pilaralisib, SAR245408;PILARALISIB (XL147);SAR245408;XL 147;XL-147; SAR245408;XL147;XL 147;SAR-245408;SAR 245408;XL-147;SAR245408;XL147;XL 147;SAR-245408;SAR 245408; PILARALISIB;2-amino-N-[3-[[3-(2-chloro-5-methoxyanilino)quinoxalin-2-yl]sulfamoyl]phenyl]-2-methylpropanamide
- CBNumber:
- CB72666700
- Molecular Formula:
- C25H25ClN6O4S
- Molecular Weight:
- 541.02
- MDL Number:
- MFCD26142605
- MOL File:
- 934526-89-3.mol
- MSDS File:
- SDS
Melting point | 216-220oC |
---|---|
Density | 1.458±0.06 g/cm3(Predicted) |
storage temp. | Refrigerator |
solubility | DMSO (Slightly) |
pka | 6.33±0.30(Predicted) |
form | Solid |
color | Light Yellow to Yellow |
FDA UNII | 60ES45KTMK |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07,GHS08 |
---|---|
Signal word | Danger |
Hazard statements | H372-H302 |
Precautionary statements | P260-P264-P270-P314-P501-P264-P270-P301+P312-P330-P501 |
pilaralisib price More Price(13)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 18011 | Pilaralisib ≥98% | 934526-89-3 | 5mg | $81 | 2024-03-01 | Buy |
Cayman Chemical | 18011 | Pilaralisib ≥98% | 934526-89-3 | 10mg | $153 | 2024-03-01 | Buy |
Cayman Chemical | 18011 | Pilaralisib ≥98% | 934526-89-3 | 25mg | $323 | 2024-03-01 | Buy |
Cayman Chemical | 18011 | Pilaralisib ≥98% | 934526-89-3 | 50mg | $581 | 2023-06-20 | Buy |
TRC | P441390 | Pilaralisib | 934526-89-3 | 10mg | $120 | 2021-12-16 | Buy |
pilaralisib Chemical Properties,Uses,Production
Uses
Pilaralisib is a pan-PI3K inhibitor used in the treatment of patients with chronic lymphocytic leukemia or relapsed or refractory lymphoma.
Enzyme inhibitor
This selective, reversible, and ATP-competitive Class I PI3K inhibitor (FW = 541.02 g/mol; CAS 934526-89-3; Solubility: 100 mg/mL DMSO, when warmed; < 1 mg/mL H2O), also known as XL147, SAR245408, and N-(3- {[(3-{[2-chloro-5-(methoxy)phenyl]-amino}quinoxalin-2- yl)amino]sulfonyl}phenyl)-2-methylalaninamide, targets PI3Kα (IC50 = 39 nM, PI3Kδ (IC50 = 36 nM), and PI3Kγ (IC50 = 23 nM), but only weakly for PI3Kβ. Pilaralisib is active against human breast cancer cell lines with constitutive PI3K activation. PI3K inhibitors reduce AKT activity and relieves suppression of receptor tyrosine kinase expression and activity. XL147 shows dose-dependent inhibition of cell growth and levels of pAKT and pS6, signal transducers in the PI3K/AKT/TOR pathway. In HER2- overexpressing cells, pilaralisib inhibition of PI3K is attended by upregulation of expression and phosphorylation of multiple receptor tyrosine kinases, including HER3. Knockdown of FoxO1 and FoxO3a transcription factors suppressed the induction of HER3, InsR, IGF1R, and FGFR2 mRNAs upon inhibition of PI3K. In HER2(+) cells, knockdown of HER3 with siRNA or cotreatment with the HER2 inhibitors trastuzumab or lapatinib enhance XL147-induced cell death and inhibition of pAKT and pS6. When tested separately, trastuzumab and lapatinib synergized with XL147 for inhibition of pAKT and growth of established BT474 xenografts. Compared with XL147 alone, the combination exhibited a superior antitumor effect against trastuzumab-resistant tumor xenografts.
pilaralisib Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29823 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52861 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
PT CHEM GROUP LIMITED | peter68@ptchemgroup.com | China | 35426 | 58 | |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
View Lastest Price from pilaralisib manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-12-31 | pilaralisib
934526-89-3
|
US $1.00 / g | 1g | 99% | 200kg | Career Henan Chemical Co |
- pilaralisib
934526-89-3
- US $1.00 / g
- 99%
- Career Henan Chemical Co