ChemicalBook >> CAS DataBase List >>X-376
X-376
- CAS No.
- 1365267-27-1
- Chemical Name:
- X-376
- Synonyms
- X-396;X-376;CS-1720;Ensartinib;Ensartinib (X-376);(R)-6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-N-(4-(4-methylpiperazine-1-carbonyl)phenyl)pyridazine-3-carboxamide;6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-(4-methylpiperazine-1-carbonyl)phenyl]pyridazine-3-carboxamide;6-Amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-3-pyridazinecarboxamide;3-Pyridazinecarboxamide, 6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-
- CBNumber:
- CB72667853
- Molecular Formula:
- C25H25Cl2FN6O3
- Molecular Weight:
- 547.41
- MDL Number:
- MFCD25976868
- MOL File:
- 1365267-27-1.mol
- MSDS File:
- SDS
Last updated:2024-07-02 08:55:16
Boiling point | 695.1±55.0 °C(Predicted) |
---|---|
Density | 1.428±0.06 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | Ethanol:13.0(Max Conc. mg/mL);23.75(Max Conc. mM) |
form | A crystalline solid |
pka | 10.70±0.70(Predicted) |
color | White to off-white |
FDA UNII | 7DR7JMB8BH |
NCI Drug Dictionary | ensartinib |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P280-P305+P351+P338 |
X-376 price More Price(13)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 21341 | Ensartinib ≥98% | 1365267-27-1 | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 21341 | Ensartinib ≥98% | 1365267-27-1 | 5mg | $139 | 2024-03-01 | Buy |
Cayman Chemical | 21341 | Ensartinib ≥98% | 1365267-27-1 | 10mg | $243 | 2024-03-01 | Buy |
Cayman Chemical | 21341 | Ensartinib ≥98% | 1365267-27-1 | 25mg | $533 | 2024-03-01 | Buy |
ChemScene | CS-6077 | X-376 98.36% | 1365267-27-1 | 50mg | $550 | 2021-12-16 | Buy |
X-376 Chemical Properties,Uses,Production
Uses
X-376 is an ALK inhibitor with potential efficacy in the treatment of non-small cell lung cancer.
Side effects
The more common side effects of X-376 treatment include rash, itching, edema, and anemia.
Physiological effects
Ensatinib (X-376) is a second-generation tyrosine kinase inhibitor (TKI) small-molecule targeted drug targeting ALK fusion, which can selectively bind to the products of two driver gene mutations, ALK and MET. Block the activation and transmission of downstream signaling pathways, thereby inhibiting the growth and proliferation of cancer cells with these mutations, and exerting anti-cancer effects.
Synthesis of X-376 from C[C@H](C1=C(C=CC(F)=C1Cl)Cl)OC2=CC(C(NC3=CC=C(C(N4CCN(CC4)C)=O)C=C3)=O)=NN=C2N(C(OC(C)(C)C)=O)C(OC(C)(C)C)=O
X-376 Preparation Products And Raw materials
Global( 83)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Zhengzhou Anhuida Chemical Co., Ltd | +8615903659408 | admin@ahdchem.com | China | 297 | 58 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
TianYuan Pharmaceutical CO.,LTD | +86-755-23284190 13684996853 | sales@tianpharm.com | CHINA | 304 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Shanghai Huici Pharmaceutical Technology Co., LTD | +8618917134367 | lixing@pharmahuici.com | China | 133 | 58 |
1365267-27-1(X-376)Related Search:
X-376
X-396
6-Amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-3-pyridazinecarboxamide
Ensartinib
(R)-6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-N-(4-(4-methylpiperazine-1-carbonyl)phenyl)pyridazine-3-carboxamide
6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-(4-methylpiperazine-1-carbonyl)phenyl]pyridazine-3-carboxamide
CS-1720
3-Pyridazinecarboxamide, 6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-
Ensartinib (X-376)
1365267-27-1
C25H25Cl2FN6O3