BI 6015
- CAS No.
- 93987-29-2
- Chemical Name:
- BI 6015
- Synonyms
- B16015;BI 6015;2-Methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole;2-Methyl-1-(2-methyl-5-nitrophenylsulfonyl)-1H-benzo[d]imidazole;1H-Benzimidazole, 2-methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-;inhibit,promoter,HNF4α,factor,hepatocyte,Inhibitor,diabetes,insulin,BI-6015,BI6015,nuclear,cancer,BI 6015
- CBNumber:
- CB72695661
- Molecular Formula:
- C15H13N3O4S
- Molecular Weight:
- 331.35
- MDL Number:
- MFCD04406654
- MOL File:
- 93987-29-2.mol
| Boiling point | 570.6±60.0 °C(Predicted) |
|---|---|
| Density | 1.45±0.1 g/cm3(Predicted) |
| storage temp. | +2C to +8C |
| solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml). |
| form | Beige powder |
| pka | 0.88±0.10(Predicted) |
| color | Tan |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
BI 6015 price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 375240 | HNF4 Antagonist, BI6015 - CAS 93987-29-2 - Calbiochem The HNF4 Antagonist, BI6, also referenced under CAS 93987-29-2, controls the biological activity of HNF4. |
93987-29-2 | 25mg | $259 | 2024-03-01 | Buy |
| Cayman Chemical | 12032 | BI6015 ≥95% | 93987-29-2 | 5mg | $48 | 2024-03-01 | Buy |
| Cayman Chemical | 12032 | BI6015 ≥95% | 93987-29-2 | 10mg | $86 | 2024-03-01 | Buy |
| Cayman Chemical | 12032 | BI6015 ≥95% | 93987-29-2 | 50mg | $360 | 2024-03-01 | Buy |
| Tocris | 4641 | BI6015 ≥98%(HPLC) | 93987-29-2 | 50 | $828 | 2021-12-16 | Buy |
BI 6015 Chemical Properties,Uses,Production
Description
BI-6015 (93987-29-2) is a hepatocyte nuclear factor 4α (HNF4α) antagonist. HNF4α is a central regulator of gene expression in cell types that play a central role in metabolic homeostasis.1 BI-6015 binds to HNF4α with high affinity and modulates the expression of known target genes. It was shown to be selectively cytotoxic to cancer cell lines in vitro and in vivo however in vivo potency was limited by suboptimal pharmacokinetics.2 BI-6015 represents the first small molecule tool for pharmacologic modulation of HNF4α activity.2 Cell permeable.
Uses
BI 6015 is a known HNF4α antagonist that represses the expression of known HNF4α target genes. Studies have shown that BI6015 are also capable of exhibiting selective cytotoxic activities against numerous tumor cell lines.
storage
Store at -20°C
References
1) Wang et al. (2000), Hepatocyte Nuclear Factor 4α Regulates the Expression of Pancreatic β-Cell Genes Implicated in Glucose Metabolism and Nutrient-induced Insulin Secretion; J. Biol. Chem., 275 35953 2) Kiselyuk et al. (2012), HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promotor; Chem. Biol., 19 806
BI 6015 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 15162312715 | sales@szzxbio.com | China | 2999 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8073 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 |