1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea

CAS No.
796967-10-7
Chemical Name:
1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea
Synonyms
1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea;VEGFR2/Flt3/c-Kit Inhibitor - CAS 796967-10-7 - Calbiochem;Urea, N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(3-methylphenyl)-
CBNumber:
CB73352565
Molecular Formula:
C21H19N5O
Molecular Weight:
357.41
MDL Number:
MFCD29090038
MOL File:
796967-10-7.mol
Last updated:2023-04-23 13:52:06

1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea Properties

Boiling point 549.4±50.0 °C(Predicted)
Density 1.378±0.06 g/cm3(Predicted)
storage temp. +2C to +8C
form Off-white solid
pka 14.34±0.70(Predicted)

1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea Chemical Properties,Uses,Production

General Description

A cell-permeable 3-aminoindazolylurea compound that acts as a potent and ATP-competitive inhibitor of VEGFR2/KDR (IC50 = 3 nM) as well as Flt3 and cKit (IC50 = 4 to 20 nM). Shown to block VEGF-induced VEGFR2 phosphorylation in 3T3-murine fibroblasts in vitro (IC50 = 13 nM) and exhibit oral availability (AUC = 6.5 μM?h with an oral dose of 10 mg/kg in CD-1 mice) and in vivo efficacy in a murine estradiol-induced uterine edema model (ED50 = 4 mg/kg p.o. in balb/c mice).

1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea Preparation Products And Raw materials

Raw materials

Preparation Products

1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Supplier Advantage
Sigma-Aldrich 80
1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea VEGFR2/Flt3/c-Kit Inhibitor - CAS 796967-10-7 - Calbiochem Urea, N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(3-methylphenyl)- 796967-10-7