1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea

1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea structure

CAS No.: 796967-10-7

Chemical Name:: 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea

Synonyms: 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea;VEGFR2/Flt3/c-Kit Inhibitor - CAS 796967-10-7 - Calbiochem;Urea, N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(3-methylphenyl)-

CBNumber:: CB73352565

Molecular Formula:: C21H19N5O

Molecular Weight:: 357.41

MDL Number:: MFCD29090038

MOL File:: 796967-10-7.mol

Last updated:2023-04-23 13:52:06

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1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea Properties

Boiling point	549.4±50.0 °C(Predicted)
Density	1.378±0.06 g/cm3(Predicted)
storage temp.	+2C to +8C
form	Off-white solid
pka	14.34±0.70(Predicted)

1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea Chemical Properties,Uses,Production

General Description

A cell-permeable 3-aminoindazolylurea compound that acts as a potent and ATP-competitive inhibitor of VEGFR2/KDR (IC₅₀ = 3 nM) as well as Flt3 and cKit (IC₅₀ = 4 to 20 nM). Shown to block VEGF-induced VEGFR2 phosphorylation in 3T3-murine fibroblasts in vitro (IC₅₀ = 13 nM) and exhibit oral availability (AUC = 6.5 μM?h with an oral dose of 10 mg/kg in CD-1 mice) and in vivo efficacy in a murine estradiol-induced uterine edema model (ED₅₀ = 4 mg/kg p.o. in balb/c mice).

1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea Preparation Products And Raw materials

Raw materials

Preparation Products

1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea Suppliers

Global( 2)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80

Supplier	Advantage
Sigma-Aldrich	80

1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea VEGFR2/Flt3/c-Kit Inhibitor - CAS 796967-10-7 - Calbiochem Urea, N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(3-methylphenyl)- 796967-10-7