ChemicalBook >제품 카탈로그 >1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea

1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea

1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea 구조식 이미지

카스 번호:: 796967-10-7

상품명:: 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea

동의어(영문):: 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea;VEGFR2/Flt3/c-Kit Inhibitor - CAS 796967-10-7 - Calbiochem;Urea, N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(3-methylphenyl)-

CBNumber:: CB73352565

분자식:: C21H19N5O

포뮬러 무게:: 357.41

MOL 파일:: 796967-10-7.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 2

1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea 속성

끓는 점: 549.4±50.0 °C(Predicted)

밀도: 1.378±0.06 g/cm3(Predicted)

저장 조건: +2C to +8C

물리적 상태: 회백색 고체

산도 계수 (pKa): 14.34±0.70(Predicted)

안전

1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea C화학적 특성, 용도, 생산

일반 설명

A cell-permeable 3-aminoindazolylurea compound that acts as a potent and ATP-competitive inhibitor of VEGFR2/KDR (IC₅₀ = 3 nM) as well as Flt3 and cKit (IC₅₀ = 4 to 20 nM). Shown to block VEGF-induced VEGFR2 phosphorylation in 3T3-murine fibroblasts in vitro (IC₅₀ = 13 nM) and exhibit oral availability (AUC = 6.5 μM?h with an oral dose of 10 mg/kg in CD-1 mice) and in vivo efficacy in a murine estradiol-induced uterine edema model (ED₅₀ = 4 mg/kg p.o. in balb/c mice).

1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea 준비 용품 및 원자재

원자재

준비 용품

1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea 공급 업체

글로벌( 2)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80