1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea

1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea 구조식 이미지
카스 번호:
796967-10-7
상품명:
1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea
동의어(영문):
1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea;VEGFR2/Flt3/c-Kit Inhibitor - CAS 796967-10-7 - Calbiochem;Urea, N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(3-methylphenyl)-
CBNumber:
CB73352565
분자식:
C21H19N5O
포뮬러 무게:
357.41
MOL 파일:
796967-10-7.mol
MSDS 파일:
SDS

1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea 속성

끓는 점
549.4±50.0 °C(Predicted)
밀도
1.378±0.06 g/cm3(Predicted)
저장 조건
+2C to +8C
물리적 상태
회백색 고체
산도 계수 (pKa)
14.34±0.70(Predicted)

안전

1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea C화학적 특성, 용도, 생산

일반 설명

A cell-permeable 3-aminoindazolylurea compound that acts as a potent and ATP-competitive inhibitor of VEGFR2/KDR (IC50 = 3 nM) as well as Flt3 and cKit (IC50 = 4 to 20 nM). Shown to block VEGF-induced VEGFR2 phosphorylation in 3T3-murine fibroblasts in vitro (IC50 = 13 nM) and exhibit oral availability (AUC = 6.5 μM?h with an oral dose of 10 mg/kg in CD-1 mice) and in vivo efficacy in a murine estradiol-induced uterine edema model (ED50 = 4 mg/kg p.o. in balb/c mice).

1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea 준비 용품 및 원자재

원자재

준비 용품


1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea 공급 업체

글로벌( 2)공급 업체
공급자 전화 이메일 국가 제품 수 이점
Sigma-Aldrich 021-61415566 800-8193336
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