ChemicalBook >> CAS DataBase List >>(4-BROMOPHENYL)[3-FLUORO-4-[[6-(METHYL-2-PROPENYLAMINO)HEXYL]OXY]PHENYL]-METHANONE

(4-BROMOPHENYL)[3-FLUORO-4-[[6-(METHYL-2-PROPENYLAMINO)HEXYL]OXY]PHENYL]-METHANONE

(4-BROMOPHENYL)[3-FLUORO-4-[[6-(METHYL-2-PROPENYLAMINO)HEXYL]OXY]PHENYL]-METHANONE structure

CAS No.: 161582-11-2

Chemical Name:: (4-BROMOPHENYL)[3-FLUORO-4-[[6-(METHYL-2-PROPENYLAMINO)HEXYL]OXY]PHENYL]-METHANONE

Synonyms: RO 48-8071;(4-Bromophenyl)[2-fluoro-4-[[6-(methyl-2-propenylamino)hexyl]oxy]phenyl]methanone;(4-BROMOPHENYL)[3-FLUORO-4-[[6-(METHYL-2-PROPENYLAMINO)HEXYL]OXY]PHENYL]-METHANONE;Methanone, (4-broMophenyl)[2-fluoro-4-[[6-(Methyl-2-propenylaMino)hexyl]oxy]phenyl]-;Methanone, (4-bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]-

CBNumber:: CB7379585

Molecular Formula:: C23H27BrFNO2

Molecular Weight:: 448.37

MDL Number:: MFCD18432703

MOL File:: 161582-11-2.mol

Last updated:2023-06-08 09:03:08

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(4-BROMOPHENYL)[3-FLUORO-4-[[6-(METHYL-2-PROPENYLAMINO)HEXYL]OXY]PHENYL]-METHANONE Properties

Boiling point	522.8±50.0 °C(Predicted)
Density	1.235±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:2): .25 mg/ml
pka	8.88±0.50(Predicted)
FDA UNII	YDR69X9Q9M

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07

Signal word

Danger

Hazard statements

H225-H319-H336

Precautionary statements

P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501

NFPA 704

	3
2		0

(4-BROMOPHENYL)[3-FLUORO-4-[[6-(METHYL-2-PROPENYLAMINO)HEXYL]OXY]PHENYL]-METHANONE price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	10006415	Ro 48-8071 ≥95%	161582-11-2	5mg	$41	2024-03-01	Buy
Cayman Chemical	10006415	Ro 48-8071 ≥95%	161582-11-2	10mg	$78	2024-03-01	Buy
Cayman Chemical	10006415	Ro 48-8071 ≥95%	161582-11-2	50mg	$322	2024-03-01	Buy
Cayman Chemical	10006415	Ro 48-8071 ≥95%	161582-11-2	100mg	$561	2024-03-01	Buy
Usbiological	464785	Ro 48-8071	161582-11-2	5mg	$326	2021-12-16	Buy

Product number	Packaging	Price	Buy
10006415	5mg	$41	Buy
10006415	10mg	$78	Buy
10006415	50mg	$322	Buy
10006415	100mg	$561	Buy
464785	5mg	$326	Buy

(4-BROMOPHENYL)[3-FLUORO-4-[[6-(METHYL-2-PROPENYLAMINO)HEXYL]OXY]PHENYL]-METHANONE Chemical Properties,Uses,Production

Description

Oxidosqualene cyclase (OSC) is a microsomal enzyme that catalyzes the cyclization of monooxidosqualene to lanosterol in the cholesterol synthetic pathway. Ro 48-8071 is an inhibitor of oxidosqualene cyclase (OSC) that has low-density lipoprotein (LDL) cholesterol lowering activity similar to the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) inhibitor simvastatin. It inhibits OSC from human liver microsomes and HepG2 cells with IC₅₀ values of approximately 6.5 nM and 1.5 nM, respectively. Ro 48-8071 lowered LDL cholesterol ~40% in hamsters at a dose of 150 μg/kg without affecting high-density lipoprotein levels and with no sign of liver toxicity. Ro 48-8071 increases cytochrome P3A mRNA and protein levels in primary rat and murine hepatocyte cultures with a maximal effect at 30 μM.

Uses

Ro 48-8071 is an inhibitor of oxidosqualene cyclase.

Definition

ChEBI: An aromatic ketone that is 2-fluoro-4'-bromobenzophenone in which the hydrogen at position 4 (meta to the fluoro group) is replaced by a 6-[methyl(prop-2-en-1-yl)amino]hexyl}oxy group. An inhibitor of lanosterol synthase.

(4-BROMOPHENYL)[3-FLUORO-4-[[6-(METHYL-2-PROPENYLAMINO)HEXYL]OXY]PHENYL]-METHANONE Preparation Products And Raw materials

Raw materials

Preparation Products

(4-BROMOPHENYL)[3-FLUORO-4-[[6-(METHYL-2-PROPENYLAMINO)HEXYL]OXY]PHENYL]-METHANONE Suppliers

Global( 60)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42057	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2923	55
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4863	58
CEG Chemical Science&Technology Co., Ltd.	Mobile:13665161512		China	1785	58
LETOPHARM LIMITED	+86-21-5821 5861	sales@letopharm.com	China	2384	58
D&C Chemicals	+86-21-58447131	1724405207@qq.com	China	472	55
BOC Sciences	16314854226	info@bocsci.com	United States	9926	65
Medi-tech Bioscientific Co., Ltd.	0519-83246372 13585352506		China	1844	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Jilin Chinese Academy of Sciences-yanshen Technology	58
Shanghai Boyle Chemical Co., Ltd.	55
MedChemexpress LLC	58
CEG Chemical Science&Technology Co., Ltd.	58
LETOPHARM LIMITED	58
D&C Chemicals	55
BOC Sciences	65
Medi-tech Bioscientific Co., Ltd.	58

(4-BROMOPHENYL)[3-FLUORO-4-[[6-(METHYL-2-PROPENYLAMINO)HEXYL]OXY]PHENYL]-METHANONE Spectrum

(4-BROMOPHENYL)[3-FLUORO-4-[[6-(METHYL-2-PROPENYLAMINO)HEXYL]OXY]PHENYL]-METHANONE(161582-11-2)¹HNMR

161582-11-2((4-BROMOPHENYL)[3-FLUORO-4-[[6-(METHYL-2-PROPENYLAMINO)HEXYL]OXY]PHENYL]-METHANONE)Related Search:

4-BROMO-3-FLUORO-4'-METHOXYBENZOPHENONE 3-BROMO-4'-ETHOXYBENZOPHENONE 97 (4-BROMOPHENYL)[3-FLUORO-4-[[6-(METHYL-2-PROPENYLAMINO)HEXYL]OXY]PHENYL]-METHANONE 4-BROMO-4'-METHOXYBENZOPHENONE

RO 48-8071 (4-BROMOPHENYL)[3-FLUORO-4-[[6-(METHYL-2-PROPENYLAMINO)HEXYL]OXY]PHENYL]-METHANONE Methanone, (4-broMophenyl)[2-fluoro-4-[[6-(Methyl-2-propenylaMino)hexyl]oxy]phenyl]- (4-Bromophenyl)[2-fluoro-4-[[6-(methyl-2-propenylamino)hexyl]oxy]phenyl]methanone Methanone, (4-bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]- 161582-11-2 C23H27BrFNO2