ChemicalBook >> CAS DataBase List >>(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE

(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE

(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE structure

CAS No.: 87173-97-5

Chemical Name:: (+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE

Synonyms: U-62066;U-62066 (mesylate);SPIRADOLINE MESYLATE;rel-3,4-dichloro-N-methyl-N-[(5S,7R,8R)-7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-benzeneacetamide,monomethanesulfonate;(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE

CBNumber:: CB7468579

Molecular Formula:: C23H34Cl2N2O5S

Molecular Weight:: 521.49

MDL Number:: MFCD00153876

MOL File:: 87173-97-5.mol

Last updated:2025-04-17 18:22:24

(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE Properties

storage temp.	2-8°C
solubility	H₂O: 14 mg/mL
form	solid
color	white
FDA UNII	U4E85084FG

SAFETY

Risk and Safety Statements

WGK Germany	3

(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE Chemical Properties,Uses,Production

Uses

Analgesic.

in vivo

Spiradoline mesylate (U-62066; 0.1-0.4 mg/kg; subcutaneous injection; once; Sprague-Dawley rats) treatment dose-dependently reduces social behaviors in non-stressed adults, producing social avoidance at the highest dose tested, while younger animals displays reduced sensitivity to this socially suppressing effect of Spiradoline mesylate. In stressed animals, the socially suppressing effects of the Spiradoline mesylate are blunted at all ages, with juveniles and adolescents exhibiting increased social preference in response to certain doses of U-62066^[1].

Animal Model:	Juvenile, adolescent and adult Sprague-Dawley male and female rats exposured to repeated restraint^[1]
Dosage:	0.1 mg/kg, 0.2 mg/kg, 0.3 mg/kg, and 0.4?mg/kg
Administration:	Subcutaneous injection; once
Result:	Dose-dependently reduced social behaviors in non-stressed adults, producing social avoidance at the highest dose tested.

(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

87173-97-5((+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE)Related Search:

(1R,2R)-N,N'-Dimethyl-1,2-cyclohexanediamine 1,2-Diaminocyclohexane (1R,2R)-(-)-1,2-Diaminocyclohexane (R)-(+)-1,2-Diaminopropane dihydrochloride 4-Methylcyclohexyl amine

trans-4-Aminocyclohexanol hydrochloride trans-4-(Dimethylamino)cyclohexanol 4-ACETAMIDOCYCLOHEXANOL N,N'-Dimethyl-1,2-cyclohexanediamine (R,R)-(-)-1,2-DIAMINOCYCLOHEXANE HYDROCHLORIDE

1,2-Cyclohexanediamine,N,N-dimethyl-,(1R,2R)-(9CI) N-(2-phenylethyl)cyclohexanamine TRANS-(1R,2R)-N,N'-BISMETHYL-1,2-CYCLOHEXANEDIAMINE HCL (2R,3R)-(+)-2,3-BUTANEDIAMINE DIHYDROCHLORIDE CHEMBRDG-BB 4024898

TRANS-4-(METHYLAMINO)CYCLOHEXANOL (3,4-DICHLOROPHENYL)ACETALDEHYDE CHEMBRDG-BB 4018237

1of4

SPIRADOLINE MESYLATE U-62066 (+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE U-62066 (mesylate) rel-3,4-dichloro-N-methyl-N-[(5S,7R,8R)-7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-benzeneacetamide,monomethanesulfonate 87173-97-5