Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Structure
7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one structure
CAS No.
160129-45-3
Chemical Name:
7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one
Synonyms
7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one;Tovaptan impurity 29;Tovaptan impurity 24;Tolvaptan Impurity 29;7-chloro-2,3,4,5-tetrahydro-;7-Chlorobenzo[b]azepan-5-one;7-chloro-1,2,3,4-tetrahydro-1-benzazepin-5-one;7-chloro-1,2,3,4-tetrahydrobenzo [b] aza-5-one;7-chloro-1, 2, 3, 4-benzo [b] AZA Zhuo-5-ketone;Chloro-1,2,3,4-tetrahydro-5H-1-benzozepin-5-one
CBNumber:
CB7477186
Molecular Formula:
C10H10ClNO
Molecular Weight:
195.65
MDL Number:
MFCD06738694
MOL File:
160129-45-3.mol
MSDS File:
SDS
Last updated:2024-04-26 14:50:00
Request For Quotation

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Properties

Melting point 103.0 to 107.0 °C
Boiling point 356.5±41.0 °C(Predicted)
Density 1.234±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 2.36±0.20(Predicted)
color Off-White to Pale Yellow
InChI InChI=1S/C10H10ClNO/c11-7-3-4-9-8(6-7)10(13)2-1-5-12-9/h3-4,6,12H,1-2,5H2
InChIKey AHESNFIUAHTYGS-UHFFFAOYSA-N
SMILES N1C2=CC=C(Cl)C=C2C(=O)CCC1

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard Codes  T
Risk Statements  25
Safety Statements  45
HS Code  2933998090

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical C2896 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one >98.0%(GC)(T) 160129-45-3 1g $81 2024-03-01 Buy
TCI Chemical C2896 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one >98.0%(GC)(T) 160129-45-3 5g $321 2024-03-01 Buy
TRC C366265 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one 160129-45-3 10g $415 2021-12-16 Buy
Usbiological 162272 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one 160129-45-3 1g $418 2021-12-16 Buy
Biosynth Carbosynth FC51283 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one 160129-45-3 100g $500 2021-12-16 Buy
Product number Packaging Price Buy
C2896 1g $81 Buy
C2896 5g $321 Buy
C366265 10g $415 Buy
162272 1g $418 Buy
FC51283 100g $500 Buy

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one is an intermediate in the synthesis of Tolvaptan (T536650) (OPC-41061), an orally active nonpeptide arginine vasopressin V2 receptor antagonist

Synthesis

The synthetic method of 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one comprises the following steps: carrying out an acylation reaction between 4-chloroaniline and succinic anhydride to obtain 4-(4-chloroaniline)-4-oxobutyric acid; carrying out an intramolecular Friedel-Craft reaction on 4-(4-chloroaniline)-4-oxobutyric acid to obtain 7-chloro-3,4-tetrahydrobenzo[b]azepine-2,5-one; reacting 7-chloro-3,4-tetrahydrobenzo[b]azepine-2,5-one with ethylene glycol to obtain 7-chloro-3,4-tetrahydrobenzo[b]azepine-2-one-5-glycol ketal; reducing 7-chloro-3,4-tetrahydrobenzo[b]azepine-2-one-5-glycol ketal, and carrying out de-ketalation under an acidic condition to obtain 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one.

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Preparation Products And Raw materials

Raw materials

Preparation Products

5-Dehydro Tolvaptan

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Suppliers

Global( 290)Suppliers
Supplier Tel Email Country ProdList Advantage
Enki Biopharmaceuticals (Shanghai) Limited
+86-0086-2157680326 +8613916707528 yusu@enkibiopharma.com China 46 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15954 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21687 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9340 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Nanjing Dolon Biotechnology Co.,Ltd. 		18905173768 sales@dolonchem.com CHINA 2972 58
Jinan Finer Chemical Co., Ltd 		+86-531-88989536 +86-15508631887 sales@finerchem.com China 2966 58
Accela ChemBio Inc. 		(+1)-858-699-3322 info@accelachem.com United States 19965 58
Supplier Advantage
Enki Biopharmaceuticals (Shanghai) Limited
58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
career henan chemical co 		58
Nanjing Dolon Biotechnology Co.,Ltd. 		58
Jinan Finer Chemical Co., Ltd 		58
Accela ChemBio Inc. 		58

View Lastest Price from 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
7-Chloro-1，2，3，4-tetrahydrobenzo(b)azepin-5-one pictures 2024-06-03 7-Chloro-1，2，3，4-tetrahydrobenzo(b)azepin-5-one
160129-45-3
 US $0.00 / kg 25kg 99.0% 10000 Enki Biopharmaceuticals (Shanghai) Limited
7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE pictures 2022-10-15 7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE
160129-45-3
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE pictures 2019-08-05 7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE
160129-45-3
 US $1.00 / g 1g 99% 2 tons Cangzhou Wanyou New Material Technology Co.,Ltd

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Spectrum

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one(160129-45-3)1HNMR

160129-45-3(7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one)Related Search:

2-Methyl-4-nitrobenzoic acid Tolvaptan Impurity 30 7-Chloro-1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one Tolvaptan Impurity 17 Tolvaptan impurity 2
Tolvaptan Impurity 20 Tolvaptan Impurity 15 Tolvaptan Impurity 11 Tolvaptan Impurity 26 6-CHLORO-1H-BENZIMIDAZOLE
6-Chloro-2-benzoxazolethiol 5-Dehydro Tolvaptan 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 1,2,3,4-Tetrahydro-benzo[b]azepin-5-one
2,3,4,5-Tetrahydro-1H-benzo[b]azepine 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one 7-CHLORO-9-METHOXY-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE

1of4

7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 7-chloro-1, 2, 3, 4-benzo [b] AZA Zhuo-5-ketone 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzozepin-5-one 5H-1-Benzazepin-5-one,7-chloro-1,2,3,4-tetrahydro- 7-Chlorobenzo[b]azepan-5-one 7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 7-chloro-1,2,3,4-tetrahydro-1-benzazepin-5-one Tolvaptan Impurity 29 7-CHLORO-1,2,3,4-TERTRAHYDROBENZO(B) AZEPIN-5-ONE 7-chloro-2,3,4,5-tetrahydro- 7-chloro-1,2,3,4-tetrahydrobenzo [b] aza-5-one 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one > 7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-ones 7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one 7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine Tovaptan impurity 29 Tovaptan impurity 24 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepine-5-One Chloro-1,2,3,4-tetrahydro-5H-1-benzozepin-5-one 160129-45-3 Building Blocks/Intermediates Tolvaptan intermediate