PD 146176
- CAS No.
- 4079-26-9
- Chemical Name:
- PD 146176
- Synonyms
- NSC168807;PD146176 (NSC168807);6,11-dihydrothiochromeno[4,3-b]indole;[1]Benzothiopyrano[4,3-b]indole, 6,11-dihydro-;inhibit,tau,brain,triple,NSC-168807,PD146176,Autophagy,pathology,amyloidosis,transgenic,reticulocyte,impairment,cognitive,mice,NSC 168807,Inhibitor,cells,PD 146176,IC21,PD-146176,rabbit,Ferroptosis
- CBNumber:
- CB7504219
- Molecular Formula:
- C15H11NS
- Molecular Weight:
- 237.32
- MDL Number:
- MFCD05664738
- MOL File:
- 4079-26-9.mol
- MSDS File:
- SDS
Melting point | 160 °C |
---|---|
Boiling point | 485.4±24.0 °C(Predicted) |
Density | 1.333±0.06 g/cm3(Predicted) |
storage temp. | Store at +4°C |
solubility | DMSO: 16 mg/mL, soluble |
form | solid |
pka | 16.17±0.20(Predicted) |
color | cream-colored |
FDA UNII | 5K2QDA6F3S |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
Safety Statements | 22-24/25 |
WGK Germany | 3 |
PD 146176 price More Price(18)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | P4620 | PD 146176 ≥98% (HPLC), solid | 4079-26-9 | 5mg | $201 | 2024-03-01 | Buy |
Sigma-Aldrich | P4620 | PD 146176 ≥98% (HPLC), solid | 4079-26-9 | 25mg | $636 | 2024-03-01 | Buy |
Cayman Chemical | 10010518 | PD 146176 ≥98% | 4079-26-9 | 5mg | $48 | 2024-03-01 | Buy |
Cayman Chemical | 10010518 | PD 146176 ≥98% | 4079-26-9 | 10mg | $89 | 2024-03-01 | Buy |
Cayman Chemical | 10010518 | PD 146176 ≥98% | 4079-26-9 | 25mg | $210 | 2024-03-01 | Buy |
PD 146176 Chemical Properties,Uses,Production
Description
PD 146176 is a potent and selective inhibitor of reticulocyte 15-
Uses
PD 146176 has been used to study its influence on ex vivo leukotriene B4 (LTB4) and lipoxin A4 (LXA4) secretion in adipose tissue.
Definition
ChEBI: PD-146176 is an organic heterotetracyclic compound that is 1H-indole which is ortho-fused to a 2H-1-benzothiopyran group at positions 2-3. It is an inhibitor of 15-lipoxygenase that limits atherosclerotic lesion development in rabbits. It has a role as a ferroptosis inhibitor, an EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor and an antiatherogenic agent. It is an organic heterotetracyclic compound, an organosulfur heterocyclic compound and an organonitrogen heterocyclic compound.
Biological Activity
Specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (K i = 197nM) that has no demonstrable effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC 50 = 0.54 μ M for 15-LOX in rabbit reticulocytes). Lacks non-specific antioxidant properties and prevents atherogenesis via regulation of monocyte-macrophage enrichment in vivo .
Biochem/physiol Actions
PD 146176 blocks neuroprotectin D1 (NPD1) and eicosanoid synthesis by inhibiting the 5-lipoxygenase-1 (15-LOX-1) enzyme.
storage
Store at +4°C
PD 146176 Preparation Products And Raw materials
Raw materials
Preparation Products
PD 146176 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Lingyuan Bebiansen Biological Technology Co., Ltd | 18642120371 | 2837458851@qq.com | China | 9927 | 58 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
View Lastest Price from PD 146176 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-12-29 | 6,11-Dihydrothiochromeno[4,3-b]indole
4079-26-9
|
US $2.00 / KG | 1KG | ≥98% | 20 tons | Career Henan Chemical Co |
- 6,11-Dihydrothiochromeno[4,3-b]indole
4079-26-9
- US $2.00 / KG
- ≥98%
- Career Henan Chemical Co