Dimethyl methoxymethylenemalonate
- CAS No.
- 22398-14-7
- Chemical Name:
- Dimethyl methoxymethylenemalonate
- Synonyms
- DiMethyl 2-(MethoxyMethylene)Malonate;MMMM;Dimethyl 2-(methoxymethylene);Dimethylmethoxymethylenmalonat;DIMETHYL METHOXYMETHYLENEMALONATE;DimethylMethoxymethylenemalonate>Dimethyl methoxymethylenemalonate, 98+%;thyl 2-(methoxymethylidene)propanedioate;imethyl2-(methoxymethylidene)propanedioate;METHOXYMETHYLENEMALONIC ACID DIMETHYL ESTER
- CBNumber:
- CB7686827
- Molecular Formula:
- C7H10O5
- Molecular Weight:
- 174.15
- MDL Number:
- MFCD00038225
- MOL File:
- 22398-14-7.mol
- MSDS File:
- SDS
| Melting point | 40-44 °C |
|---|---|
| Boiling point | 98 °C (0.5 mmHg) |
| Density | 1.2311 (rough estimate) |
| refractive index | 1.4390 (estimate) |
| Flash point | 158 °C |
| storage temp. | Sealed in dry,Room Temperature |
| form | Crystalline Solid |
| color | White |
| InChI | InChI=1S/C7H10O5/c1-10-4-5(6(8)11-2)7(9)12-3/h4H,1-3H3 |
| InChIKey | RHFZTBSULNJWEI-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)/C(=C\OC)/C(OC)=O |
| CAS DataBase Reference | 22398-14-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H301-H315-H317-H319-H334-H335 | |||||||||
| Precautionary statements | P261-P284-P301+P310a-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 43-36/38-22 | |||||||||
| Safety Statements | 37/39-26-24 | |||||||||
| HS Code | 29171990 | |||||||||
| NFPA 704 |
|
Dimethyl methoxymethylenemalonate price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M1207 | Dimethyl Methoxymethylenemalonate >98.0%(GC) | 22398-14-7 | 25g | $32 | 2022-04-27 | Buy |
| TCI Chemical | M1207 | Dimethyl Methoxymethylenemalonate >98.0%(GC) | 22398-14-7 | 500g | $361 | 2021-12-16 | Buy |
| Usbiological | 447131 | Dimethyl 2-(Methoxymethylene)malonate | 22398-14-7 | 10mg | $468 | 2026-06-03 | Buy |
| Usbiological | 447131 | Dimethyl 2-(Methoxymethylene)malonate | 22398-14-7 | 25mg | $955 | 2026-06-03 | Buy |
| Biosynth | XAA39814 | Dimethyl 2-(Methoxymethylene)malonate | 22398-14-7 | 100g | $389 | 2026-06-05 | Buy |
Dimethyl methoxymethylenemalonate Chemical Properties, Uses, Production
Chemical Properties
white crystalline solid
Uses
Dimethyl 2-(Methoxymethylene)malonate is a useful synthetic intermediate. It is used in preparation of (phenoxyethoxy)quinolones with antimalarial activities. It is also a reagent used in the synthesis of bicyclic pyridones prepn. as oral selective CB2 agonists with anti-pruritic activity.
Synthesis
264.2 g (2.0 mol) of dimethyl malonate, 637 g (6 mol) of trimethyl orthoformate and 20.4 g (0.2 mol) of acetic anhydride containing 2 g of H2 SO4 -activated bentonite were initially introduced into a reaction flask provided with a stirrer, thermometer, dropping funnel, column and reflux condensor, and the mixture was heated to boiling. 40.8 g (0.4 mol) of acetic anhydride was continuously metered for6 hours. The low boiling component formed was distilled off at a head temperature of 62° to 67° C. The bottom temperature increased slowly from 109° to 133° C. After 8 hours; the excess orthoester was distilled off at reduced pressure. 40.8 g (0.4 mol) of acetic anhydride was added to the remaining reaction mixture, and the mixture was heated at 140° C. for 2 hours. The catalyst was filtered off, and the crude product was distilled in vacuo. 330.4 g of dimethyl methoxymethylenemalonate (98% pure), having a melting point of 44° to 46° C., were obtained at 0.5 mbar and a head temperature of 110° C.
Dimethyl methoxymethylenemalonate Preparation Products And Raw materials
Raw materials
Preparation Products
Dimethyl methoxymethylenemalonate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Haimen DsHare Pharmaceutical Technology Co., Ltd. | +86-0513-68050135 13962878782 | zhuwdsh@126.com | China | 155 | 58 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Maya High Purity Chemicals | +86 (573) 82222445 (0)18006601000 452520369 | sales@maya-r.com | China | 11693 | 57 |
View Latest Price from Dimethyl methoxymethylenemalonate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | Dimethyl methoxymethylenemalonate
22398-14-7
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2020-01-13 | DIMETHYL METHOXYMETHYLENEMALONATE
22398-14-7
|
$9.80 | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- Dimethyl methoxymethylenemalonate
22398-14-7
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- DIMETHYL METHOXYMETHYLENEMALONATE
22398-14-7
- $9.80
- ≥99%
- Career Henan Chemical Co
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