3S-3-METHYLMORPHOLINE
- CAS No.
- 350595-57-2
- Chemical Name:
- 3S-3-METHYLMORPHOLINE
- Synonyms
- (S)-3-Methylmorpholine;3S-3-METHYLMORPHOLINE;(S)-3-MethylMorpholine HCl;Morpholine, 3-Methyl-, (3S)-;3S-3-Methylmorpholine(WX604204);high quality 3S-3-METHYLMORPHOLINE
- CBNumber:
- CB7781119
- Molecular Formula:
- C5H11NO
- Molecular Weight:
- 101.15
- MDL Number:
- MFCD03840369
- MOL File:
- 350595-57-2.mol
| Boiling point | 137.1±15.0 °C(Predicted) |
|---|---|
| Density | 0.891±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 9.03±0.40(Predicted) |
| form | liquid |
| color | colourless |
| optical activity | Consistent with structure |
| InChI | InChI=1S/C5H11NO/c1-5-4-7-3-2-6-5/h5-6H,2-4H2,1H3/t5-/m0/s1 |
| InChIKey | SFWWGMKXCYLZEG-YFKPBYRVSA-N |
| SMILES | N1CCOC[C@@H]1C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H225-H319 |
| Precautionary statements | P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | 2735 |
| HazardClass | 8 |
| PackingGroup | Ⅲ |
| HS Code | 2934999090 |
3S-3-METHYLMORPHOLINE price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M320525 | (S)-3-MethylMorpholine | 350595-57-2 | 2.5g | $1175 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CCH0041131 | 3S-3-METHYL MORPHOLINE 95.00% | 350595-57-2 | 1G | $596.4 | 2021-12-16 | Buy |
| AK Scientific | J90460 | (S)-3-Methylmorpholine | 350595-57-2 | 1g | $25 | 2021-12-16 | Buy |
| Apolloscientific | OR308174 | (3S)-3-Methylmorpholine | 350595-57-2 | 1g | $72 | 2021-12-16 | Buy |
| AK Scientific | J90460 | (S)-3-Methylmorpholine | 350595-57-2 | 5g | $79 | 2021-12-16 | Buy |
3S-3-METHYLMORPHOLINE Chemical Properties,Uses,Production
Uses
It is useful in preparation of morpholinopyrimidine derivatives as mTOR kinase inhibitors for the treatment of diseases mediated by mTOR kinase and/or one or more PI3K enzymes.
Uses
(3S)-3-Methylmorpholine is useful in preparation of morpholinopyrimidine derivatives as mTOR kinase inhibitors for the treatment of diseases mediated by mTOR kinase and/or one or more PI3K enzymes
Synthesis
119844-66-5
350595-57-2
Step-4: Synthesis of (S)-3-methylmorpholine (117): lithium aluminum hydride (87 g, 3.0 eq.) was suspended in anhydrous tetrahydrofuran (1500 mL) in a three necked round bottomed flask at 0°C under nitrogen protection. (S)-5-methylmorpholin-3-one (88 g) was dissolved in anhydrous tetrahydrofuran (500 mL) and slowly added dropwise to the reaction system at the same temperature. The reaction mixture was gradually warmed to room temperature and stirred continuously overnight. Upon completion of the reaction, it was quenched sequentially with water (100 mL), 2N sodium hydroxide solution (200 mL), and water (300 mL) (using Fisher post-treatment method) and stirred for 30 minutes. Subsequently, a 2% methanol/dichloromethane mixture (1000 mL) was added and stirring was continued for 1.0 hour. The crude product was filtered through a diatomaceous earth pad, and the filtrate was dried over anhydrous sodium sulfate and finally concentrated on a rotary evaporator at a low water bath temperature of 20-25 °C to afford the target product (S)-3-methylmorpholine (55 g, 71% yield).
References
[1] Patent: WO2014/16849, 2014, A2. Location in patent: Page/Page column 126; 127; 128
[2] Synthesis (Germany), 2014, vol. 46,
[3] Patent: US2008/255114, 2008, A1. Location in patent: Page/Page column 17
[4] Patent: EP1785418, 2007, A1. Location in patent: Page/Page column 148
[5] Patent: CN106749081, 2017, A. Location in patent: Paragraph 0016; 0017; 0018; 0019; 0020; 0021
3S-3-METHYLMORPHOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29731 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21622 | 55 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49733 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8829 | 58 |
View Lastest Price from 3S-3-METHYLMORPHOLINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-02-25 | (S)-3-methylmorpholine
350595-57-2
|
US $100.00 / KG | 1KG | 98% | 100KG | Hong Kong Tiansheng New Material Trading Co., Ltd | |
 |
2022-02-25 | (3S)-3-methylmorpholine
350595-57-2
|
US $100.00 / KG | 1KG | 98% | 10KG | Hong Kong Tiansheng New Material Trading Co., Ltd | |
 |
2019-09-05 | 3S-3-METHYLMORPHOLINE
350595-57-2
|
US $5.00 / KG | 1KG | 95%-98% | 100kg | Career Henan Chemical Co |
-
- (S)-3-methylmorpholine
350595-57-2
- US $100.00 / KG
- 98%
- Hong Kong Tiansheng New Material Trading Co., Ltd
-
- (3S)-3-methylmorpholine
350595-57-2
- US $100.00 / KG
- 98%
- Hong Kong Tiansheng New Material Trading Co., Ltd
-
- 3S-3-METHYLMORPHOLINE
350595-57-2
- US $5.00 / KG
- 95%-98%
- Career Henan Chemical Co
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