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Fluanisone

Fluanisone structure

CAS No.: 1480-19-9

Chemical Name:: Fluanisone

Synonyms: R 2028;R 2167;2028 Md;MD 2028;Fluanison;Anti-pica;Sedalande;Fluanisone;Haloanison;NSC 170977

CBNumber:: CB7875027

Molecular Formula:: C21H25FN2O2

Molecular Weight:: 356.43

MDL Number:: MFCD00366636

MOL File:: 1480-19-9.mol

Last updated:2024-03-27 16:40:14

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Fluanisone Properties

Melting point	67.5-68.5°
Boiling point	511.8±50.0 °C(Predicted)
Density	1.146
storage temp.	Refrigerator
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	7.43±0.10(Predicted)
form	Solid
color	Off-White to Pale Yellow
FDA UNII	1D0W98U1I4
ATC code	N05AD09

SAFETY

Risk and Safety Statements

Toxicity	LD50 i.p. in mice: 200 mg/kg (Cascio)

Fluanisone price More Price(8)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	012092	Fluanisone	1480-19-9	50mg	$460	2021-12-16	Buy
TRC	F406800	Fluanisone	1480-19-9	1g	$1420	2021-12-16	Buy
TRC	F406800	Fluanisone	1480-19-9	2g	$2605	2021-12-16	Buy
American Custom Chemicals Corporation	API0015262	FLUANISONE 95.00%	1480-19-9	5MG	$496.31	2021-12-16	Buy
Medical Isotopes, Inc.	58057	Fluanisone	1480-19-9	50mg	$650	2021-12-16	Buy

Product number	Packaging	Price	Buy
012092	50mg	$460	Buy
F406800	1g	$1420	Buy
F406800	2g	$2605	Buy
API0015262	5MG	$496.31	Buy
58057	50mg	$650	Buy

Fluanisone Chemical Properties,Uses,Production

Originator

Sedalande ,J and J

Uses

Fluanisone is a neuroleptic with sedative properties and relatively poorly expressed antipsychotic action. It is used as an independent or adjuvant drug for psychomotor excitement in severe and chronic schizophrenia and for manic-depressive disorder.

Uses

Fluanisone is a butyrophenone derivative with sedative properties. It is a typical antipsychotic and is used in the treatment of schizophrenia.

Definition

ChEBI: Fluanisone is an aromatic ketone.

Manufacturing Process

To a suspension of 341 parts of aluminum chloride in 1740 parts of carbon disulfide are added 96 parts of fluorobenzene with stirring and cooling. While the temperature is maintained at about 10°C, 141 parts of γ-chlorobutyryl chloride are added. After the addition is completed, the cooling bath is removed and the stirring is continued for 2 hours. The reaction mixture is poured into ice water. The organic layer is separated, washed with water, dried over anhydrous sodium sulfate, and filtered. The filtrate is concentrated under reduced pressure, and the residue is distilled to yield γ-chloro-p-fluorobutyrophenone boiling at about 136°-142°C/6 mm
A mixture of 6.6 parts of γ-chloro-p-fluoro-butyrophenone and 12.5 parts of 1- (o-anisyl)piperazine is heated for 10 hours at a temperature of 110°C. The reaction mixture is treated with 800 parts of ether and filtered. The ether layer is washed with water, dried over anhydrous potassium carbonate and filtered, whereupon hydrogen chloride gas is introduced into the solution. The precipitate is collected on a filter and dissolved in a mixture of 240 parts of 2- propanol and 80 parts of acetone to yield 1-[γ-(p-fluorobenzoyl)propyl]-4-(o-anisyl)piperazine hydrochloride. This monohydrochloride is collected on a filter and dissolved in 240 parts of 2-propanol. Anhydrous, gaseous hydrogen chloride is passed through the solution. On cooling, the 1-[γ-(p-fluorobenzoyl) propyl]-4-(o-anisyl)piperazine dihydrochloride precipitates.
A second crop of product is obtained by passing hydrogen chloride gas through the solution of mother liquors. The pale-brown, amorphous powder is collected on a filter and found to melt at about 205°-205.5°C.
This salt is dissolved in water and treated with sodium hydroxide. The precipitated base is recovered by filtration and recrystallized from diisopropyl ether. The white crystals melt at about 67.5°-68.5°C.

Therapeutic Function

Neuroleptic

Synthesis

Fluanisone, 4??-fluoro-4-[4-(o-methoxyphenyl)-1-piperazinyl]-butyrophenone (6.3.12), is synthesized by reacting 1-(2??-methoxyphenyl)-piperazine with 4-chloro- 4??-fluorobutyrophenone (6.3.4) [50].

Synthesis_1480-19-9

Fluanisone Preparation Products And Raw materials

Raw materials

1-(2-Methoxyphenyl)piperazine Aluminum chloride Fluorobenzene

Preparation Products

Fluanisone Suppliers

Global( 91)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Xiamen Wonderful Bio Technology Co., Ltd.	+8613043004613	Sara@xmwonderfulbio.com	China	305	58
Shaanxi Franta Biotechnology Co., Ltd	+86-13082019107 +86-13082019107	admin@flanderff.com	China	229	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Hebei Runbin Biotechnology Co. LTD	13180553332	2179877681@qq.com	CHINA	996	58
Hebei Lihe Biotechnology Co.,ltd	86-311-80292533 13315122300	sales@lihebiotech.com	CHINA	305	58

Supplier	Advantage
Hebei Yanxi Chemical Co., Ltd.	58
Henan Bao Enluo International TradeCo.，LTD	58
Xiamen Wonderful Bio Technology Co., Ltd.	58
Shaanxi Franta Biotechnology Co., Ltd	58
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Runbin Biotechnology Co. LTD	58
Hebei Lihe Biotechnology Co.,ltd	58

View Lastest Price from Fluanisone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-03-27	fluanisone 1480-19-9	US $20.00 / kg	1kg	99	1000kg	Shaanxi Franta Biotechnology Co., Ltd
2024-01-18	fluanisone 1480-19-9	US $15.00 / kg	1kg	99%	large quantity	Xiamen Wonderful Bio Technology Co., Ltd.
2023-09-08	Fluanisone 1480-19-9	US $50.00 / kg	1kg	0.99	10000	Hebei Yanxi Chemical Co., Ltd.

fluanisone
1480-19-9
US $20.00 / kg
99
Shaanxi Franta Biotechnology Co., Ltd

fluanisone
1480-19-9
US $15.00 / kg
99%
Xiamen Wonderful Bio Technology Co., Ltd.

Fluanisone
1480-19-9
US $50.00 / kg
0.99
Hebei Yanxi Chemical Co., Ltd.

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Fluanisone 1-Butanone, 1-(4-fluorophenyl)-4-4-(2-methoxyphenyl)-1-piperazinyl- 2028 Md 4-[4-(o-Methoxyphenyl)-1-piperazinyl]-p-fluorobutyrophenone 4'-Fluoro-4-[4-(o-methoxyphenyl)-1-piperazinyl]butyrophenone Anti-pica Butyrophenone, 4'-fluoro-4-[4-(o-methoxyphenyl)-1-piperazinyl]- Fluanison Haloanison 1-(4-Fluorophenyl)-4-[4-(2-methoxyphenyl)-1-piperazinyl]-1-butanone Haloanisone MD 2028 NSC 170977 p-Fluoro-γ-[4-(o-Methoxyphenyl)-1-piperazinyl]butyrophenone R 2028 R 2167 Sedalande γ-(4-o-Methoxyphenylpiperazino)-4-fluorobutyrophenone 1-(4-fluorophenyl)-4-[4-(2-methoxyphenyl)piperazin-1-yl]butan-1-one 1-(4-fluorophenyl)-4-4-(2-methoxyphenyl)-1-piperazinyl Flusnisone Fluanisone USP/EP/BP 1480-19-9 C21H25FN2O2 Aromatics Heterocycles Intermediates & Fine Chemicals Neurochemicals Pharmaceuticals