prednimustine
- CAS No.
- 29069-24-7
- Chemical Name:
- prednimustine
- Synonyms
- LEO-1031;Sterecyt;Stereocyt;NSC 171345;NSC-134087;Prednimustin;prednimustine;prednimustine USP/EP/BP;HFVNWDWLWUCIHC-GUPDPFMOSA-N;Prednisolone chloraMbucil ester
- CBNumber:
- CB7933444
- Molecular Formula:
- C35H45Cl2NO6
- Molecular Weight:
- 646.64
- MDL Number:
- MFCD00866487
- MOL File:
- 29069-24-7.mol
| Melting point | 163-164° |
|---|---|
| alpha | D24 +92.9° (c = 1.06 in chloroform) |
| Boiling point | 791.5±60.0 °C(Predicted) |
| Density | 1.30±0.1 g/cm3(Predicted) |
| pka | 12.32±0.70(Predicted) |
| FDA UNII | 9403SIO2S8 |
| IARC | 3 (Vol. 50) 1990 |
| ATC code | L01AA08 |
prednimustine Chemical Properties,Uses,Production
Originator
Stereocyt, Bellon ,France ,1978
Uses
Antineoplastic.
Definition
ChEBI: Prednimustine is a corticosteroid hormone.
Manufacturing Process
p-[N-bis(β-chloroethyl)amino] phenyl butyric acid was dissolved in a mixture of 150 ml dry benzene and 8.04 ml dry pyridine. The solution was cooled in an ice bath, and a solution of thionyl chloride in 30 ml dry benzene was slowly added with stirring under anhydrous conditions.
The reaction mixture was then kept at room temperature for 1 hour and thereafter poured into a mixture of 5.0 N HCl and crushed ice. The benzene solution was immediately washed with water, with cold 1.0 N NaHCO3 and finally with cold water. After drying over anhydrous sodium sulfate, the benzene was removed in vacuo. The residue is the p-[N-bis(βchloroethyl)amino]phenyl butyric anhydride which could be used without any further purification.
To a solution of 42.0 g of p-[N-bis(β-chloroethyl)amino]phenyl butyric anhydride in 500 ml dry pyridine was added 24.4 g of prednisolone. The reaction mixture was kept at room temperature for 24 hours under anhydrous condition. It was then poured into a mixture of concentrated HCl and crushed ice and extracted with ether-ethyl acetate (1:1).
The organic phase was washed several times with cold 1.0 N K2CO3 and finallywater. After drying over CaCl2 the solvent was removed in vacuo.
The residue is prednisolone 21-[4'-[p-bis(β-chloroethyl)amino]phenyl]butyrate which after crystallization from methanol/water had a melting point of 163°C to 164°C.
Therapeutic Function
Cancer chemotherapy
prednimustine Preparation Products And Raw materials
prednimustine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
| Shaanxi Dideu Newmaterial Co., Ltd. | 029-63373950 15353716720 | 1052@dideu.com | China | 10007 | 58 |
| Supplier | Advantage |
|---|---|
| Dideu Industries Group Limited | 58 |
| LGM Pharma | 70 |
| Shaanxi Dideu Newmaterial Co., Ltd. | 58 |
View Lastest Price from prednimustine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-06 | prednimustine USP/EP/BP
29069-24-7
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
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- prednimustine USP/EP/BP
29069-24-7
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited