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Sorbinil

Sorbinil Structure
Sorbinil structure
CAS No.
68367-52-2
Chemical Name:
Sorbinil
Synonyms
CP-45634;(S)-(+)-Sorbinil;Sorbinil >=98% (HPLC);inhibit,Aldose Reductase,Sorbinil,Inhibitor;(+)-(4S)-6-Fluorospiro[chroman-4,4′-imidazolidine]-2′,5′-dione;(4S)-6-fluorospiro[2,3-dihydrochromene-4,5'-imidazolidine]-2',4'-dione;(4S)-6-Fluorospiro[2H-1-benzopyran-4(3H),4'-imidazolidine]-2',5'-dione;(S)-6-Fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione;(4S)-6-Fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione;(4S)-6'-Fluoro-2',3'-dihydrospiro[imidazolidine-4,4'-[4H][1]benzopyran]-2,5-dione
CBNumber:
CB81117527
Molecular Formula:
C11H9FN2O3
Molecular Weight:
236.2
MDL Number:
MFCD00867380
MOL File:
68367-52-2.mol
MSDS File:
SDS
Last updated:2023-09-04 15:51:00
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Sorbinil Properties

Melting point 241-243°
alpha D25 +54.0° (c = 1 in methanol)
Density 1.52
storage temp. 2-8°C
solubility DMSO: ≥20mg/mL
form powder
pka 8.91±0.20(Predicted)
color white to off-white
optical activity [α]/D +50 to +60°, c = 1 in methanol
FDA UNII G4186B906P

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3

Sorbinil price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S7701 Sorbinil ≥98% (HPLC) 68367-52-2 5mg $140 2024-03-01 Buy
Sigma-Aldrich S7701 Sorbinil ≥98% (HPLC) 68367-52-2 25mg $545 2024-03-01 Buy
ChemScene CS-0002274 Sorbinil 98.31% 68367-52-2 1mg $235 2021-12-16 Buy
Product number Packaging Price Buy
S7701 5mg $140 Buy
S7701 25mg $545 Buy
CS-0002274 1mg $235 Buy

Sorbinil Chemical Properties,Uses,Production

Uses

Enzyme inhibitor (aldose reductase).

Uses

Sorbinil has been used as an aldose reductase inhibitor in diabetic rats as a positive control group.

Definition

ChEBI: An azaspiro compound having a monofluoro-substituted chromane skeleton spiro-linked to an imidazolidinedione ring.

Biochem/physiol Actions

Sorbinil decreases the level of sorbitol in red blood cells and increases the velocity of nerve conduction. It maintains the myo-inositol content in the nerve and prevents the reduction of sodium-potassium ATPase activity. This action is beneficial in providing symptomatic relief in patients with diabetic neuropathy.

Sorbinil Preparation Products And Raw materials

Raw materials

Preparation Products

Sorbinil Suppliers

Global( 20)Suppliers
Supplier Tel Email Country ProdList Advantage
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49390 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3420 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Shanghai Synchem Pharma Co., ltd 021-61984905-1 18016477331 synchempharma@aliyun.com China 6454 55
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9730 58
Hefei fuya biotechnology co. LTD 18096409024 sales02@foreversyn.com China 1938 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44941 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 15801484223 psaitong@jm-bio.com China 29834 58
Supplier Advantage
Hubei Jusheng Technology Co.,Ltd. 		58
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Sigma-Aldrich 80
Shanghai Synchem Pharma Co., ltd 55
Fan De(Beijing) Biotechnology Co., Ltd. 58
Hefei fuya biotechnology co. LTD 58
Energy Chemical 58
Beijing Jin Ming Biotechnology Co., Ltd. 58

Sorbinil Spectrum

Sorbinil(68367-52-2)1HNMR

68367-52-2(Sorbinil)Related Search:

(S)-1-(3-Fluorophenyl)ethanamine 2-ETHOXYPHENETHYLAMINE H-PHG-NH2 HCL (R)-1-(3-Fluorophenyl)ethylamine 6-FLUOROCHROMAN
3-(4-fluorophenoxy)propan-1-amine N-(2-METHOXYPHENETHYL)UREA 6-FLUORO-4-CHROMANONE HYDANTOIN 1-(3-FLUOROPHENYL)PROPYLAMINE Sorbinil
FIDARESTAT (S)-(+)-NIRVANOL [3-(4-FLUOROPHENOXY)PROPYL]METHYLAMINE (RS)-N-[1-(3-FLUOROPHENYL)ETHYL]METHYLAMINE 2-(2-METHOXYPHENYL)-ACETAMIDE
3-(3-FLUOROPHENYL)-DL-BETA-ALANINOL 2H-1-Benzopyran-4-amine,3,4-dihydro-,(4S)-(9CI) 6-FLUORO-CHROMAN-4-YLAMINE HYDROCHLORIDE

1of4

Spiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione, 6-fluoro-2,3-dihydro-, (4S)- (4S)-6'-Fluoro-2',3'-dihydrospiro[imidazolidine-4,4'-[4H][1]benzopyran]-2,5-dione (4S)-6-Fluorospiro[2H-1-benzopyran-4(3H),4'-imidazolidine]-2',5'-dione (S)-6-Fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione CP-45634 (4S)-6-Fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione (S)-(+)-Sorbinil (+)-(4S)-6-Fluorospiro[chroman-4,4′-imidazolidine]-2′,5′-dione (4S)-6-fluorospiro[2,3-dihydrochromene-4,5'-imidazolidine]-2',4'-dione Sorbinil >=98% (HPLC) inhibit,Aldose Reductase,Sorbinil,Inhibitor 68367-52-2