Tetraethylene glycol p-toluenesulfonate
- CAS No.
- 77544-60-6
- Chemical Name:
- Tetraethylene glycol p-toluenesulfonate
- Synonyms
- PEG5-Tos;Tos-PEG4;Tos-PEG4-OH;OH-PEG4-Tos;PEG5-Tosylate;Hydroxy-PEG5-Tos;HO-(CH2CH2O)4-Tos;Tetraethylene glycol tosylate;Tetraethylene glycol monotosylate;Monotosylated tetraethylene glycol
- CBNumber:
- CB81231414
- Molecular Formula:
- C15H24O7S
- Molecular Weight:
- 348.41
- MDL Number:
- MFCD22056303
- MOL File:
- 77544-60-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H314 |
| Precautionary statements | P270-P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338 |
| Hazard Codes | T,Xi |
| Risk Statements | 25-34-36 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 2927 8(6.1) / PGII |
| WGK Germany | 3 |
Tetraethylene glycol p-toluenesulfonate price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 764388 | Tetraethylene glycol p-toluenesulfonate 97% | 77544-60-6 | 1g | $72.5 | 2024-03-01 | Buy |
| TRC | H533740 | 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol | 77544-60-6 | 200mg | $160 | 2021-12-16 | Buy |
| SynQuest Laboratories | 6664-1-06 | Tetraethylene glycol p-toluenesulfonate 97% | 77544-60-6 | 1g | $104 | 2021-12-16 | Buy |
| AK Scientific | Y4976 | Tetraethylene glycol p-toluenesulfonate | 77544-60-6 | 1g | $147 | 2021-12-16 | Buy |
| SynQuest Laboratories | 6664-1-06 | Tetraethylene glycol p-toluenesulfonate 97% | 77544-60-6 | 250mg | $75 | 2021-12-16 | Buy |
Tetraethylene glycol p-toluenesulfonate Chemical Properties,Uses,Production
Description
PEG5-Tos is a PEG linker containing a hydroxyl group with a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The tosyl group is a very good leaving group for nucleophilic substitution reactions.
Uses
Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tetraethylene glycol monotosylate also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.
Preparation
Synthesis of tetraethylene glycol tosylate. To a solution of tetraethylene glycol (2.22 g, 11.4 mmol, 3.8 equiv) in THF at 0 °C was added 2.5 M NaOH (2 mL, 5.0 mmol, 1.7 equiv) and stirred for 30 min. Tosyl chloride (565.3 mg, 3.0 mmol, 1 equiv) was added in small portions and the mixture stirred for 5 h. The solvent was removed under reduced pressure, and the residue was taken up in CH2Cl2 (15 mL) and washed with water (3 × 10 mL). The aqueous wash was further extracted with CH2Cl2 (3 × 10 mL) and the combined organic fractions were washed with brine and dried over anhydrous Na2SO4. The dried solution was filtered and the filtrate was concentrated under reduced pressure to give 900.8 mg of a pale yellow oil (87%). The product was sufficiently pure to be used without further purification.
Tetraethylene glycol p-toluenesulfonate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3149 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19185 | 58 |
View Lastest Price from Tetraethylene glycol p-toluenesulfonate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-25 | OH-PEG4-Tos
77544-60-6
|
US $0.00 / g | 10g | >98.00% | 10g | Xian confluore Biological Technology Co., Ltd. |
-
- OH-PEG4-Tos
77544-60-6
- US $0.00 / g
- >98.00%
- Xian confluore Biological Technology Co., Ltd.
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