Succinylcholine
- CAS No.
- 306-40-1
- Chemical Name:
- Succinylcholine
- Synonyms
- Diacetylcholine;SUCCINYLCHOLINE;2,2'-(succinylbis(oxy))bis(N,N,N-triMethylethanaMiniuM);2,2'-[(1,4-Dioxo-1,4-butanediyl)bis(oxy)]bis[N,N,N-trimethylethanaminium];2,2'-[(1,4-Dioxobutane-1,4-diyl)bis(oxy)]bis[N,N,N-trimethyl-1-ethanaminium]
- CBNumber:
- CB81383210
- Molecular Formula:
- C14H30N2O4
- Molecular Weight:
- 0
- MDL Number:
- MFCD00421789
- MOL File:
- 306-40-1.mol
| Boiling point | 432.48°C (rough estimate) |
|---|---|
| Density | 1.0386 (rough estimate) |
| refractive index | 1.5060 (estimate) |
| FDA UNII | J2R869A8YF |
SAFETY
Risk and Safety Statements
| Toxicity | A synthetic muscle relaxant with a curare-like action. Although the selectivity and superficial nature of the paralysis produced by succinylcholine mirrors that of tubocurarine, the specific action is quite different. Succinylcholine is classified as a depolarizing blocking agent, and it blocks acetylcholine receptors by persistent depolarization rather than by the competitive antagonism seen with true curarimimetics. In addition, succinylcholine is inactivated by cholinesterases, limiting the duration of its action. |
|---|
Succinylcholine Chemical Properties,Uses,Production
Description
Succinylcholine is the only therapeutically used depolarizing neuromuscular blocker. Unlike nondepolarizing substances, succinylchloride is not a competitive antagonist; conversely, it is a more stable agonist than acetylcholine. In this manner, succinylcholine differs from acetylcholine only in duration—it lasts longer, causing a more stable depolarization. Thus the process of repolarization is blocked and the muscles relax. During this period, muscles that cause fine movement (ocular, facial, neck) are the most sensitive and are blocked first, after which muscles of the extremities are blocked, and finally the most stable respiratory muscles. Restoration occurs upon completion of drug action.
Originator
Anectine,Glaxo Wellcome
Uses
Therapeutic use of succinylcholine consists of preventing involuntary patient movement. It is used for brief operations, intubation of the trachea, and other endoscopic procedures. Synonyms of this drug are listenon, midarine, sucostrin, ditilin, and others.
Definition
ChEBI: A quaternary ammonium ion that is the bis-choline ester of succinic acid.
Manufacturing Process
For the first time Fusko with coworkers synthesied the succinylcholine in 1949
year.
By the etherification of succinic acid chloroanhydride with
dimethylaminoethanol hydrochloride in the presence of sodium hydroxide
succinylcholine was prepared. Then the obtained succinylcholine was purified.
To the succinylcholine the methylchloride was added (1:2 mols) and the
succinylcholine dichloride was obtained as white powder.
The succinylcholine is used as succinylcholine diiodide. This salt may be
prepeared identicaly.
Therapeutic Function
Muscle relaxant
Synthesis
Succinylcholine, 2,2-[(1,4-dioxo-1,4-butanediyl)bis(oxy)]bis[N,N,Ntrimethylethanaminium( diacetylcholine)] dichloride, which can be viewed as a dimeric molecule of acetylcholine (diacetylcholine), is synthesized by reacting succinic acid dichloride with 2-dimethylaminoethanol and subsequent transformation of the resulting bis-(2-dimethylaminoethyl) succinate (15.1.13) into a quaternary salt, succinylcholine (15.1.14).
Succinylcholine Preparation Products And Raw materials
Succinylcholine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Syntechem Co.,Ltd | info@syntechem.com | China | 12990 | 57 | |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12338 | 58 |
| TCI (Shanghai) Chemical Trading Co., Ltd. | 021-61109150 | sales@tcisct.com | China | 31183 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 029-81124267 15229202216 | 1073@dideu.com | China | 10011 | 58 |
| Supplier | Advantage |
|---|---|
| Syntechem Co.,Ltd | 57 |
| Beijing HuaMeiHuLiBiological Chemical | 58 |
| TCI (Shanghai) Chemical Trading Co., Ltd. | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 58 |