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2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)1H-indol- 5-ol

2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)1H-indol- 5-ol Structure
2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)1H-indol- 5-ol structure
CAS No.
Chemical Name:
2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)1H-indol- 5-ol
Synonyms
PP242 hydrate;2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)1H-indol- 5-ol
CBNumber:
CB82445706
Molecular Formula:
C16H16N6O
Molecular Weight:
308.33784
MDL Number:
MFCD12828866
MOL File:
Mol file
Last updated:2023-04-23 13:52:06
Request For Quotation

2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)1H-indol- 5-ol Properties

storage temp. 2-8°C
form powder
color off-white

SAFETY

Risk and Safety Statements

WGK Germany  2

2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)1H-indol- 5-ol price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P0037 PP242 hydrate ≥98% (HPLC), powder 5MG $241 2023-06-20 Buy
Sigma-Aldrich P0037 PP242 hydrate ≥98% (HPLC), powder 25MG $942 2023-01-07 Buy
American Custom Chemicals Corporation API0008360 PP242 HYDRATE 95.00% 25MG $1234.58 2021-12-16 Buy
American Custom Chemicals Corporation API0008360 PP242 HYDRATE 95.00% 5MG $754.68 2021-12-16 Buy
Product number Packaging Price Buy
P0037 5MG $241 Buy
P0037 25MG $942 Buy
API0008360 25MG $1234.58 Buy
API0008360 5MG $754.68 Buy

2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)1H-indol- 5-ol Chemical Properties,Uses,Production

Uses

PP242 hydrate has been used:

  • as a mammalian target of rapamycin (mTOR) inhibitor to study its effects on rat fibroblast mTOR complex 1 and 2 (mTORC1 & 2) signaling
  • as an mTOR inhibitor to treat mouse embryonic fibroblasts (MEF) and cumulus cells (CCs) to study its effects on reactivation of embryonic nucleoli and ribosome biogenesis
  • as a target of rapamycin (TOR) kinase inhibitor for the treatment of Arabidopsis to study its effects against Fusarium graminearum infection

Biochem/physiol Actions

PP242 is a potent and selective mTOR inhibitor. PP242 is a first selective inhibitor that targets ATP domain of mTOR.

2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)1H-indol- 5-ol Preparation Products And Raw materials

Raw materials

Preparation Products

2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)1H-indol- 5-ol Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
SynphaBase AG -- info@synphabase.ch Switzerland 628 60
Riedel-de Haen AG -- United States 6825 87
Supplier Advantage
SynphaBase AG 60
Riedel-de Haen AG 87
2-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)1H-indol- 5-ol PP242 hydrate Heterocyclic Building Blocks