6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine
- CAS No.
- 1042224-63-4
- Chemical Name:
- 6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine
- Synonyms
- 6-imidazo[1;IRAK inhibitor;IRAK inhibitor 1;Cyclopamine inhibitor 1;2-a]pyridin-3-yl-N-4-piperidinyl-;6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine;2-PyridinaMine, 6-iMidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-;IRAK inhibitor 1,Inhibitor,inhibit,Interleukin-1 receptor associated kinase,IL-1R associated kinase,IRAK inhibitor1,IRAK inhibitor-1,IRAK
- CBNumber:
- CB82604194
- Molecular Formula:
- C17H19N5
- Molecular Weight:
- 293.37
- MDL Number:
- MFCD22124480
- MOL File:
- 1042224-63-4.mol
6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ApexBio Technology | A3500 | IRAKinhibitor1 | 1042224-63-4 | 5mg | $225 | 2021-12-16 | Buy |
ChemScene | CS-0603 | IRAKinhibitor1 >99.0% | 1042224-63-4 | 5mg | $290 | 2021-12-16 | Buy |
ApexBio Technology | A3500 | IRAKinhibitor1 | 1042224-63-4 | 10mg | $307 | 2021-12-16 | Buy |
ApexBio Technology | A3500 | IRAKinhibitor1 | 1042224-63-4 | 50mg | $378 | 2021-12-16 | Buy |
ChemScene | CS-0603 | IRAKinhibitor1 >99.0% | 1042224-63-4 | 10mg | $396 | 2021-12-16 | Buy |
6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine Chemical Properties,Uses,Production
Biological Activity
the interleukin-1 receptor associated kinase (irak) family is comprised of four family members irak-1, irak-2, irak-3/m, and irak-4. upon activation of their upstream cognate receptors, irak-4 is thought to phosphorylate irak-1 resulting in the activation and autophosphorylation of irak-1 an subsequent phosphorylation of downstream substrates. irak inhibitor 1 is an inhibitor of interleukin-1 receptor associated kinase 4 (irak-4).
in vitro
the regioisomeric pyridines irak inhibitor 1 (6) and it analogue (7) showed contrasting sar, with the 2,6-pyridine isomer irak inhibitor 1 having low-nanomolar potency whilst the 2,4-pyridine isomer 7 showed little activity, despite having a more accessible bidentate-binding motif. at 10 μm, irak inhibitor 1 was found to have 39% inhibition for jnk-1 and 15% inhibition for jnk-2, respectivley [1].
target
IRAK-4
IC 50
35 nm for irak-4
References
[1] buckley gm, ceska ta, fraser jl, gowers l, groom cr, higueruelo ap, jenkins k, mack sr, morgan t, parry dm, pitt wr, rausch o, richard md, sabin v. irak-4 inhibitors. part ii: a structure-based assessment of imidazo[1,2-a]pyridine binding. bioorg med chem lett. 2008;18(11):3291-5.
6-Imidazo[1,2-a]pyridin-3-yl-N-4-piperidinyl-2-pyridinamine Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 6011 | 61 |
Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
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