3,4-Dichloro-N-(1-Methylbutyl)benza-Mide
- CAS No.
- 7497-07-6
- Chemical Name:
- 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide
- Synonyms
- CS-1114;NSC 405020;NSC 405020, >=98%;NSC 405020;NSC-405020;NSC 405020, 7497-07-6;NSC405020, 98%, MT1-MMP inhibitor;3,4-DICHLORO-N-(PENTAN-2-YL)BENZAMIDE;3,4-Dichloro-N-(1-Methylbutyl)benza-Mide;Benzamide, 3,4-dichloro-N-(1-methylbutyl)-;3,4-Dichloro-N-(1-methylbutyl)-benzamide NSC405020
- CBNumber:
- CB82658339
- Molecular Formula:
- C12H15Cl2NO
- Molecular Weight:
- 260.16
- MDL Number:
- MFCD02006898
- MOL File:
- 7497-07-6.mol
| Boiling point | 353.7±32.0 °C(Predicted) |
|---|---|
| Density | 1.182±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). |
| pka | 13.38±0.46(Predicted) |
| form | powder |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
3,4-Dichloro-N-(1-Methylbutyl)benza-Mide price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0518 | NSC405020 ≥98% (HPLC) | 7497-07-6 | 5mg | $123 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0518 | NSC405020 ≥98% (HPLC) | 7497-07-6 | 25mg | $386 | 2024-03-01 | Buy |
| Cayman Chemical | 14859 | NSC 405020 ≥98% | 7497-07-6 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 14859 | NSC 405020 ≥98% | 7497-07-6 | 5mg | $63 | 2024-03-01 | Buy |
| Cayman Chemical | 14859 | NSC 405020 ≥98% | 7497-07-6 | 10mg | $109 | 2024-03-01 | Buy |
3,4-Dichloro-N-(1-Methylbutyl)benza-Mide Chemical Properties,Uses,Production
Description
NSC-405020 (7497-07-6) is a membrane type-1 matrix metalloproteinase (MMP14 or MT1-MMP) inhibitor that prevents homodimerization and inhibits MMP14’s protumorigenic activity?in vivo. (IC50?> 100 μM). Inhibition is via interaction with the hemopexin domain (PEX) of MMP14. NSC-405020 does not interfere with the catalytic activity of MT1-MMP or MMP-2.? Suppresses bone erosion in a c-Fos-deficient mouse model.2?Decreases arsenic-mediated invasion of human squamous cell carcinoma HSC5 cells.3
Uses
NSC 405020 is a novel, selective, and noncatalytic membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor that directly interacts with the homopexin (PEX) domain of MT1-MMP.
storage
Store at RT
References
1) Remacle?et al.?(2012),?Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth;? Cancer Res.,?72?2339 2) Kittaka?et al.?(2018)?Cherubism Mice Also Deficient in c-Fos Exhibit Inflammatory Bone Destruction Executed by Macrophages That Express MMP14 Despite the Absence of TRAP+ Osteoclasts?; J. Bone Miner. Res.,?33?167 3) Thang?et al.?(2014)?Bidirectional functions of arsenic as a carcinogen and an anti-cancer agent in human squamous cell carcinoma; PLoS One,?9(5)?e96945
3,4-Dichloro-N-(1-Methylbutyl)benza-Mide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 |
View Lastest Price from 3,4-Dichloro-N-(1-Methylbutyl)benza-Mide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-31 | NSC 405020
7497-07-6
|
US $1.00 / KG | 1KG | Min98% HPLC | g/kg/ton | Career Henan Chemical Co |
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- NSC 405020
7497-07-6
- US $1.00 / KG
- Min98% HPLC
- Career Henan Chemical Co