RWJ-51204
- CAS No.
- 205701-85-5
- Chemical Name:
- RWJ-51204
- Synonyms
- RWJ-51204;RWJ51204,RWJ 51204;RWJ-51204, 10 mM in DMSO;Pyrido[1,2-a]benzimidazole-4-carboxamide, 5-(ethoxymethyl)-7-fluoro-N-(2-fluorophenyl)-1,2,3,5-tetrahydro-3-oxo-
- CBNumber:
- CB83175581
- Molecular Formula:
- C21H19F2N3O3
- Molecular Weight:
- 399.39
- MDL Number:
- MFCD06198736
- MOL File:
- 205701-85-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| RWJ-51204 | FIA70185 | 1mg | $1627.69 |
| RWJ-51204 | CS-6733 | 1mg | $619 |
| RWJ-51204 | AA002A8G | 1mg | $188 |
| RWJ-51204 | AA002A8G | 5mg | $418 |
| RWJ-51204 | AA002A8G | 10mg | $563 |
| Boiling point | 533.0±50.0 °C(Predicted) |
|---|---|
| Density | 1.41±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 10.81±0.70(Predicted) |
| FDA UNII | NNJ1LL72JS |
RWJ-51204 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FIA70185 | RWJ-51204 | 205701-85-5 | 1mg | $1627.69 | 2026-06-04 | Buy |
| ChemScene | CS-6733 | RWJ-51204 | 205701-85-5 | 1mg | $619 | 2026-06-04 | Buy |
| aablocks | AA002A8G | RWJ-51204 | 205701-85-5 | 1mg | $188 | 2026-05-28 | Buy |
| aablocks | AA002A8G | RWJ-51204 | 205701-85-5 | 5mg | $418 | 2026-05-28 | Buy |
| aablocks | AA002A8G | RWJ-51204 | 205701-85-5 | 10mg | $563 | 2026-05-28 | Buy |
RWJ-51204 Chemical Properties,Uses,Production
Uses
RWJ-51204 is a partial agonist of GABA(A) receptor, with Ki of 0.2-2 nM to the benzodiazepine site on GABA(A) receptors.
in vivo
RWJ-51204 is orally active in anxiolytic efficacy tests. WJ 51204 dose-relatedly antagonizes PTZ-induced clonic convulsions when administered orally (ED50 = 0.04 mg/kg). RWJ-51204 is effective in the conflict test in monkeys (ED50 of approximately 0.5 mg/kg p.o.). RWJ-51204 potently impairs rotarod performance in rats (ED50 = 0.12 mg/kg), and all rats given RWJ-51204 orally at 30 mg/kg exhibit sedation, reduced skeletal muscle tone, and impairment of rotarod performance.
References
[1] Dubinsky B, et al. 5-ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5]imidazo[1,2a]pyridine-4-N-(2-fluorophenyl)carboxamide (RWJ-51204), a new nonbenzodiazepine anxiolytic. J Pharmacol Exp Ther. 2002 Nov;303(2):777-90. DOI:10.1124/jpet.102.036954
RWJ-51204 Preparation Products And Raw materials
Raw materials
Preparation Products
RWJ-51204 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| Beijing xinyanhui pharmaceutical research and development co., LTD | 13969155946 | 1461866103@qq.com | China | 16111 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10336 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29757 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24955 | 58 |
| Suzhou Meishi Biotechnology Co., Ltd. | 1173954148q | meishipharma@126.com | China | 20033 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11972 | 58 |
| Sangon Biotech (Shanghai) Co.,Ltd. | 400-821-026 | Sales@sangon.com | China | 6813 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |
