AX-024 hydrochloride
- CAS No.
- 1704801-24-0
- Chemical Name:
- AX-024 hydrochloride
- Synonyms
- AX-024;AX-024;AX024;AX 024;AX-024 hydrochloride;1-((4-(4-Fluorophenyl)-6-methoxy-2H-chromen-3-yl)methyl)pyrrolidine hydrochloride;AX 024,Interleukin Related,Inhibitor,inhibit,Tumor Necrosis Factor Receptor,AX024 hydrochloride,TNFR,Interferon-α/β receptor,AX024,AX-024,IFNAR,TNF Receptor,AX 024 hydrochloride,Interferon-alpha/beta receptor
- CBNumber:
- CB83364105
- Molecular Formula:
- C21H23ClFNO2
- Molecular Weight:
- 375.87
- MDL Number:
- MFCD31628548
- MOL File:
- 1704801-24-0.mol
| storage temp. | -20° |
|---|---|
| solubility | Soluble in DMSO (up to at least 25 mg/ml with warming) or in Water (10 mg/ml with warming). |
| form | solid |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
AX-024 hydrochloride price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27333 | AX-024 (hydrochloride) | 1704801-24-0 | 1mg | $40 | 2024-03-01 | Buy |
| Cayman Chemical | 27333 | AX-024 (hydrochloride) | 1704801-24-0 | 25mg | $680 | 2024-03-01 | Buy |
| Cayman Chemical | 27333 | AX-024 (hydrochloride) | 1704801-24-0 | 5mg | $167 | 2024-03-01 | Buy |
| Cayman Chemical | 27333 | AX-024 (hydrochloride) | 1704801-24-0 | 10mg | $312 | 2024-03-01 | Buy |
| ChemScene | CS-8002 | AX-024hydrochloride | 1704801-24-0 | 10mg | $300 | 2021-12-16 | Buy |
AX-024 hydrochloride Chemical Properties,Uses,Production
Description
AX-024 is an inhibitor of the CD3ε-Nck interaction. It binds to the SH3.1 N-terminal domain of Nck1, preventing its binding to the proline-rich sequence of the CD3ε subunit of T cells. AX-024 inhibits T cell receptor-triggered T cell activation (IC50 = 1 nM for human T cells) and selectively decreases proliferation of T cells over B cells. It prevents CD4+ T cell and macrophage infiltration to the cerebellum and spinal cord and improves neurological impairments in a MOG35-55 mouse model of experimental autoimmune encephalomyelitis (EAE) when administered at a dose of 10 mg/kg per day for ten days starting on the day of immunization. AX-024 (50 mg/kg) prevents the infiltration of eosinophils, macrophages, and neutrophils into the airway, as well as prevents an increase in IL-4 levels in bronchoalveolar lavage fluid (BALF), in an ovalbumin-sensitized mouse model of allergic airway disease. It does not prevent the memory T cell response to an immunodominant B8R poxvirus antigen peptide or to infection by ectromelia virus (mousepox).
Uses
AX-024 is a T cell receptor inhibitor for the treatment of autoimmune diseases.
References
1) Borroto et al. (2016), First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases; Sci. Transl. Med., 8 370ra184
AX-024 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 16803 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |