SR 1001
- CAS No.
- 1335106-03-0
- Chemical Name:
- SR 1001
- Synonyms
- SR 1001;SR-1001;SR 1001;SR1001 >=98% (HPLC);N-(5-(N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)sulphamoyl)-4-methylthiazol-2-yl)acetamide;N-(5-{[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxy-2-propanyl)phenyl]sulfamoyl}-4-methyl-1,3-thiazol-2-yl)acetamide;N-[4-Methyl-5-[[[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]sulfonyl]-2-thiazolylacetamide;SR1001,N-{4-Methyl-5-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoroMethyl-ethyl)-phenylsulfaMoyl]-thiazol-2-yl}-acetaMide;Acetamide, N-[4-methyl-5-[[[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]sulfonyl]-2-thiazolyl]-
- CBNumber:
- CB52592586
- Molecular Formula:
- C15H13F6N3O4S2
- Molecular Weight:
- 477.4
- MDL Number:
- MFCD23160036
- MOL File:
- 1335106-03-0.mol
- MSDS File:
- SDS
| Density | 1.640±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO: >5mg/mL |
| pka | 5.90±0.50(Predicted) |
| form | powder |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Protect from moisture. Solutions in DMSO may be stored at -20° for up to 3 months. |
SR 1001 price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0322 | SR1001 ≥98% (HPLC) | 1335106-03-0 | 5mg | $144 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0322 | SR1001 ≥98% (HPLC) | 1335106-03-0 | 25mg | $191.2 | 2024-03-01 | Buy |
| Cayman Chemical | 10922 | SR 1001 ≥98% | 1335106-03-0 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 10922 | SR 1001 ≥98% | 1335106-03-0 | 5mg | $106 | 2024-03-01 | Buy |
| Cayman Chemical | 10922 | SR 1001 ≥98% | 1335106-03-0 | 10mg | $186 | 2024-03-01 | Buy |
SR 1001 Chemical Properties,Uses,Production
Description
SR1001 (1335106-03-0) is a high affinity synthetic ligand for both RORα and RORγt acting as an inverse agonist. It binds specifically to the ligand-binding domain, inducing a conformational change which leads to diminished affinity for co-activators and increased affinity for co-repressors resulting in suppression of transcriptional activity.1?SR-1001 inhibits the development of murine TH17 cells2 and suppresses the expression of cytokines1. Suppresses insulitis and prevents hyperglycemia in a type 1 diabetes mouse model.3 Protects against pathologic neovascularization in various mouse models of retinopathy.4?Active in vivo
Uses
SR 1001 is a selective RORc inverse agonist.
Definition
ChEBI: SR 1001 is a sulfonamide.
References
1) Solt et al. (2011) Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand; Nature, 472 491 2) Beurel et al. (2013) Inflammatory T helper 17 cells promote depression-like behavior in mice; Biol. Psychiatry, 73 622 3) Solt et al. (2015) ROR inverse agonist suppresses insulitis and prevents hyperglycemia in a mouse model of type 1 diabetes; Endocrinology, 156 869 4) Sun et al. (2015) Nuclear receptor RORα regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation; Proc. Natl. Acad. Sci. USA, 112 10401
SR 1001 Preparation Products And Raw materials
Raw materials
Preparation Products
SR 1001 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Xiannuo Biotechnology Co., Ltd. | 021-50718719 13918719472 | China | 979 | 58 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| TargetMol Chemicals Inc. | 021-33632979 15002134094 | marketing@targetmol.com | China | 7934 | 58 |