CHAETOGLOBOSIN A
- CAS No.
- 50335-03-0
- Chemical Name:
- CHAETOGLOBOSIN A
- Synonyms
- CHAETOGLOBOSIN;CHAETOGLOBOSINL;CHAETOGLOBOSINE;CHAETOGLOBOSINM;CHAETOGLOBOSINB;chaetoglobosins;CHAETOGLOBOSIN A;CHAETOGLOBOSIN A, B, C, D, E, F, K, Q, R, T;18-dimethyl-,(7s,13e,16s,17e,19r,21e)-ol-3-yl)-1;3H-Cyclotridec[d]oxireno[f]isoindole-8,11,12(13H)-trione
- CBNumber:
- CB8359122
- Molecular Formula:
- C32H36N2O5
- Molecular Weight:
- 528.64
- MDL Number:
- MFCD31380758
- MOL File:
- 50335-03-0.mol
- MSDS File:
- SDS
| Melting point | 188°C |
|---|---|
| Boiling point | 608.81°C (rough estimate) |
| Density | 1.1705 (rough estimate) |
| refractive index | 1.5800 (estimate) |
| storage temp. | -20°C |
| solubility | DMSO: soluble10mg/mL |
| form | solid |
| pka | 17.32±0.30(Predicted) |
| color | Yellow |
| Stability | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| FDA UNII | 73AYL68TNX |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280-P261 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2941900000 | |||||||||
| NFPA 704 |
|
CHAETOGLOBOSIN A price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0642 | Chaetoglobosin A ≥98% (HPLC) | 50335-03-0 | 1mg | $397 | 2024-03-01 | Buy |
| Cayman Chemical | 19405 | Chaetoglobosin A ≥98% | 50335-03-0 | 1mg | $113 | 2024-03-01 | Buy |
| Cayman Chemical | 19405 | Chaetoglobosin A ≥98% | 50335-03-0 | 5mg | $421 | 2024-03-01 | Buy |
| Tocris | 5804 | Chaetoglobosin A ≥98%(HPLC) | 50335-03-0 | 1 | $168 | 2021-12-16 | Buy |
| TRC | C291838 | Chaetoglobosin A | 50335-03-0 | 2.5mg | $295 | 2021-12-16 | Buy |
CHAETOGLOBOSIN A Chemical Properties,Uses,Production
Description
Chaetoglobosin A (50335-03-0) is a cytochalasin analog which targets filamentous actin. Displays cytotoxic effects against human colorectal HCT116 cells, IC50=3.15 μM.1 Preferentially induces apoptosis in chronic lymphocytic leukemia cells via targeting the cytoskeleton.2 Enhances the fibrinolytic activity of vascular endothelial cells.3
Occurrence
A complex macrocyclic alkaloid, this base has been isolated from Diplodia rnacrospora. Chaetoglobosin A possesses the property of inhibiting growth in wheat coleoptiles.
Uses
Chaetoglobosin A is a mycotoxic cytochalasan compound.
Definition
ChEBI: A cytochalasan alkaloid isolated from Chaetomium globosum and Calonectria morganii.
storage
+4°C
References
1) Li et al. (2014), Chaetoglobosins from Chaetomium globosum, an endophytic fungus in Ginkgo biloba, and their phytotoxic and cytotoxic activities; J. Agric. Food Chem., 62 3734 2) Knudsen et al. (2014), Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton; Leukemia, 28 1289 3) Shinohara et al. (2000), Enhancement of fibrinolytic activity of vascular endothelial cells by chaetoglobosin A, crinipellin B, geodin and triticone B; J. Antibiot. (Tokyo), 53 262
CHAETOGLOBOSIN A Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 27322 | 60 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29796 | 68 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |