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Nisin

Description References
Nisin
Nisin structure
CAS No.
1414-45-5
Chemical Name:
Nisin
Synonyms
MISIN;NISIN;Ambicin N;Aids032124;nsc-112903;Aids-032124;Nisin Powder;Nisin Z, ≥900 IU/mg;NisinC143H228N42O37S7;Nisin Lactococcus lactis
CBNumber:
CB2257501
Molecular Formula:
C143H230N42O37S7
Formula Weight:
3354.0705
MOL File:
1414-45-5.mol

Nisin Properties

Boiling point:
2967℃
Density 
1.02 g/mL
Flash point:
>110°(230°F)
storage temp. 
2-8°C
form 
solution
Water Solubility 
Soluble in water
Merck 
13,6592
CAS DataBase Reference
1414-45-5
EWG's Food Scores
1
FDA UNII
EN8XKG133D
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  22-24/25-36-26
WGK Germany  3
RTECS  QU3340000
10

Nisin price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N5764 Nisin from Lactococcus lactis 2.5% (balance sodium chloride and denatured milk solids) 1414-45-5 1g $55.2 2019-12-02 Buy
Sigma-Aldrich N5764 Nisin from Lactococcus lactis 2.5% (balance sodium chloride and denatured milk solids) 1414-45-5 5g $145 2019-12-02 Buy
Alfa Aesar J66370 Nisin, 900 I.U./mg 1414-45-5 1g $50.9 2020-06-24 Buy
Alfa Aesar J66370 Nisin, 900 I.U./mg 1414-45-5 5g $135 2020-06-24 Buy
Cayman Chemical 16532 Nisin A 1414-45-5 5g $113 2020-06-24 Buy

Nisin Chemical Properties,Uses,Production

Description

As a ribosomally synthesized peptide, Nisin has broad-spectrum antibacterial activity that is produced by the Lactococcus lactis. In the food industry, Nisin is obtained from the cultivating of Lactococcus lactis on natural substrates, such as milk or dextrose. It serves as a natural, antibacterial, and toxicologically safe food preservative which is protect against many bacteria that are food-spoilage pathogens. As a food additive, Nisin is popularly used in food production, such as milk, meats, fast food, beverages, health care products and medicines, etc. It is effective to decrease sterilization time, lower temperature during food sterilization, improve food quality, lessen damage to nutrition, and extend shelf life by suppressing Gram-positive spoilage and pathogenic bacteria. Besides, it has been studied as a possible treatment for infections of Clostridium difficile combined with miconazole. It was originally isolated in the late 1930s and approved as an additive for food use in the USA in the late 1960s.
Nisin functions by binding to cell wall precursor lipid components of bacteria and disrupts cell wall production. Once introduced Nisin initially blends with Lipid II, a precursor molecule used to form bacterial cell wall, to create a complex. The complex penetrates the cell wall and breaks into the cytoplasmic membrane and form pores, through which the internal cytoplasmic content oozes out leading to bacterial inhibition or death.

References

https://en.wikipedia.org/wiki/Nisin
http://www.innovateus.net/food/natural-preservative-nisin
http://www.sigmaaldrich.com/catalog/product/sigma/n5764?lang=en®ion=US&
gclid=CPu1xf6aq9MCFcSOfgodvmcHZA

Chemical Properties

Crystals from ethanol. Derived from Streptococcus lactis Lancefield Group N.

Uses

Nisin is an antimicrobial agent derived from pure culture fermenta- tions of certain strains of streptococcus lactis lancefield group n. nisin preparation contains nisin, a group of related peptides with antibiotic activity. it is used to inhibit the outgrowth of clostridium botulinum spores and toxin formation in pasteurized cheese spreads and pasteurized process cheese spreads; pasteurized cheese spread with fruits, vegetables, or meats; and pasteurized process cheese spread with fruits, vegetables, or meats.

Uses

Nisin is a particularly effective bacteriosin against C. botulinum, is allowed in processed cheese food.

Uses

An antibiotic with bactericidal action

Definition

ChEBI: A type-A lantibiotic containing 34 amino acid residues (including lanthionine (Lan), methyllanthionine (MeLan), didehydroalanine (Dha) and didehydroaminobutyric acid (Dhb)) and five thioether bridges. It is obtained by fermentation of the bacterium L ctococcus lactis and shows particular activity against Clostridium botulinum. It is used in the production of various processed foods to suppress Gram-positive spoilage and pathogenic bacteria and so extend shelf life.

Purification Methods

This polypeptide from S. lactis is purified by crystallisation from 80% (v/v) EtOH and by countercurrent distribution. The synthetic polypeptide antibiotic can also be purified by preparative HPLC and assayed by HPLC on a Nucleosil 3007C18 (6 x 250mm) column using a MeCN—0.01M HCl gradient (30-50%), at 2%/minute, and flow rate of 1.5mL/minute to give a retention time of 8.1 minutes; or MeCN—0.3M guanidine-HCl gradient (30-50%), at 2%/minute, and flow rate of 1.5ml/minute to give a retention time of 10.9minutes. FAB-MS gave the pseudomolecular ion m/z at 3352.7 (M + H)+. It is soluble in dilute acid and is stable even on boiling. [Berridge et al. Biochem J 52 529 1952, synthesis by Fukase et al. Tetrahedron Lett 29 795 1988.]

Nisin Preparation Products And Raw materials

Raw materials

Preparation Products


Nisin Suppliers

Global( 200)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Nanjing Sky Hope Tongyuan Biological Engineering Co., Ltd.
02569916489
02569916489 tongyuansales@vip.sina.com CHINA 138 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 568 55
Jiangsu Qingquan Chemical Co., Ltd.
+86-571-86589381/86589382/86589383
lyy@qqpharm.com sales1@qqpharm.com CHINA 154 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2995 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28231 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 10157 58
hdzhl biotechnology co., ltd
86-13032617415
sales@luchibiology.com CHINA 1277 58

View Lastest Price from Nisin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-05-08 nisin from streptococcus lactis
1414-45-5
US $0.01-1.00 / KG 25KG 99%min 20 tons Shaanxi Dideu Medichem Co. Ltd
2018-12-15 Nisin
1414-45-5
US $8.00 / kg 1kg 99% 100KG career henan chemical co
2018-03-09 Nisin
1414-45-5
US $80.00 / KG 10G 99% 10MT Hubei XinRunde Chemical Co., Ltd.

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