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Description References
Chemical Name:
NISIN;MISIN;Ambicin N;nsc-112903;Aids032124;Aids-032124;NisinC143H228N42O37S7;Nisin Lactococcus lactis;NISINSTREPTOCOCCUS LACTIS;Lactic acid Streptococcus
Molecular Formula:
Formula Weight:
MOL File:

Nisin Properties

Boiling point:
1.02 g/mL
Flash point:
storage temp. 
Water Solubility 
Soluble in water
CAS DataBase Reference


Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  22-24/25-36-26
WGK Germany  3
RTECS  QU3340000

Nisin price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N5764 Nisin from Lactococcus lactis 2.5% (balance sodium chloride and denatured milk solids) 1414-45-5 1g $54.6 2018-11-20 Buy
Sigma-Aldrich N5764 Nisin from Lactococcus lactis 2.5% (balance sodium chloride and denatured milk solids) 1414-45-5 5g $143 2018-11-20 Buy
Alfa Aesar J66370 Nisin, 900 I.U./mg 1414-45-5 1g $48.6 2018-11-13 Buy
Alfa Aesar J66370 Nisin, 900 I.U./mg 1414-45-5 5g $127 2018-11-13 Buy
Cayman Chemical 16532 Nisin A 1414-45-5 5g $113 2018-11-13 Buy

Nisin Chemical Properties,Uses,Production


As a ribosomally synthesized peptide, Nisin has broad-spectrum antibacterial activity that is produced by the Lactococcus lactis. In the food industry, Nisin is obtained from the cultivating of Lactococcus lactis on natural substrates, such as milk or dextrose. It serves as a natural, antibacterial, and toxicologically safe food preservative which is protect against many bacteria that are food-spoilage pathogens. As a food additive, Nisin is popularly used in food production, such as milk, meats, fast food, beverages, health care products and medicines, etc. It is effective to decrease sterilization time, lower temperature during food sterilization, improve food quality, lessen damage to nutrition, and extend shelf life by suppressing Gram-positive spoilage and pathogenic bacteria. Besides, it has been studied as a possible treatment for infections of Clostridium difficile combined with miconazole. It was originally isolated in the late 1930s and approved as an additive for food use in the USA in the late 1960s.
Nisin functions by binding to cell wall precursor lipid components of bacteria and disrupts cell wall production. Once introduced Nisin initially blends with Lipid II, a precursor molecule used to form bacterial cell wall, to create a complex. The complex penetrates the cell wall and breaks into the cytoplasmic membrane and form pores, through which the internal cytoplasmic content oozes out leading to bacterial inhibition or death.


Chemical Properties

Crystals from ethanol. Derived from Streptococcus lactis Lancefield Group N.


Nisin is an antimicrobial agent derived from pure culture fermenta- tions of certain strains of streptococcus lactis lancefield group n. nisin preparation contains nisin, a group of related peptides with antibiotic activity. it is used to inhibit the outgrowth of clostridium botulinum spores and toxin formation in pasteurized cheese spreads and pasteurized process cheese spreads; pasteurized cheese spread with fruits, vegetables, or meats; and pasteurized process cheese spread with fruits, vegetables, or meats.


An antibiotic with bactericidal action


ChEBI: A type-A lantibiotic containing 34 amino acid residues (including lanthionine (Lan), methyllanthionine (MeLan), didehydroalanine (Dha) and didehydroaminobutyric acid (Dhb)) and five thioether bridges. It is obtained by fermentation of the bacterium L ctococcus lactis and shows particular activity against Clostridium botulinum. It is used in the production of various processed foods to suppress Gram-positive spoilage and pathogenic bacteria and so extend shelf life.

Purification Methods

This polypeptide from S. lactis is purified by crystallisation from 80% (v/v) EtOH and by countercurrent distribution. The synthetic polypeptide antibiotic can also be purified by preparative HPLC and assayed by HPLC on a Nucleosil 3007C18 (6 x 250mm) column using a MeCN—0.01M HCl gradient (30-50%), at 2%/minute, and flow rate of 1.5mL/minute to give a retention time of 8.1 minutes; or MeCN—0.3M guanidine-HCl gradient (30-50%), at 2%/minute, and flow rate of 1.5ml/minute to give a retention time of 10.9minutes. FAB-MS gave the pseudomolecular ion m/z at 3352.7 (M + H)+. It is soluble in dilute acid and is stable even on boiling. [Berridge et al. Biochem J 52 529 1952, synthesis by Fukase et al. Tetrahedron Lett 29 795 1988.]

Nisin Preparation Products And Raw materials

Raw materials

Preparation Products

Nisin Suppliers

Global( 160)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22049 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20786 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 CHINA 552 55
Jiangsu Qingquan Chemical Co., Ltd.
+86-571-86589381/86589382/86589383 CHINA 177 55
career henan chemical co
+86-371-86658258 CHINA 19990 58
Shanghai JONLN Reagent Co., Ltd. 400-0066-400;021-60496031
021-55660885 China 10294 55
INTATRADE GmbH +49 3493/605464
+49 3493/605470 Germany 3587 66
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 China 15926 69
future industrial shanghai co., ltd 400-0066-400;021-60496031
021-55660885 China 2042 65
Jia Xing Isenchem Co.,Ltd 0573-85280080,18627885956
0573-85285100,QQ:2446116053 China 9781 66

View Lastest Price from Nisin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-03-09 Nisin
US $80.00 / KG 10G 99% 10MT Hubei XinRunde Chemical Co., Ltd.
2018-12-15 Nisin
US $8.00 / kg 1kg 99% 100KG career henan chemical co

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