Tetrakis(hydroxymethyl)phosphonium sulfate
- CAS No.
- 55566-30-8
- Chemical Name:
- Tetrakis(hydroxymethyl)phosphonium sulfate
- Synonyms
- thps;BIS[TETRAKIS(HYDROXYMETHYL)PHOSPHONIUM] SULFATE;Tetrakis(hydroxymethyl)Phosphonium Sulphate;Tetrahydroxymethyl phosphonium sulfate;nci-c55050;pyrosettko;Retardol S;HISHICOLIN THPS;Ncgc00091951-01;THPS (Tech Grade)
- CBNumber:
- CB8461663
- Molecular Formula:
- C8H24O12P2S
- Molecular Weight:
- 406.28
- MDL Number:
- MFCD00054243
- MOL File:
- 55566-30-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | -35°C |
|---|---|
| Boiling point | 111°C |
| Density | 1.4 g/mL at 25 °C(lit.) |
| vapor pressure | 0Pa at 20℃ |
| Flash point | 96 °C |
| storage temp. | Sealed in dry,Room Temperature |
| form | liquid |
| Specific Gravity | 1.42 |
| color | Colorless to Almost colorless |
| Water Solubility | >=10 g/100 mL at 18 ºC |
| BRN | 8521357 |
| Henry's Law Constant | 5.8×1017 mol/(m3Pa) at 25℃, HSDB (2015) |
| InChI | InChI=1S/C4H12O4P.H2O4S/c5-1-9(2-6,3-7)4-8;1-5(2,3)4/h5-8H,1-4H2;(H2,1,2,3,4)/q+1;/p-1 |
| InChIKey | HFDZMBPIARIWLN-UHFFFAOYSA-M |
| SMILES | [P+](CO)(CO)(CO)CO.S([O-])(=O)(=O)O |
| LogP | -9.8 |
| Toxicology and Carcinogenesis | Toxicology and Carcinogenesis Studies of Tetrakis(hydroxymethyl)phosphonium sulfate (THPS) (CASRN 55566-30-8) and Tetrakis(hydroxymethyl)phosphonium chloride (THPC) (CASRN 124-64-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies) |
| FDA 21 CFR | 176.300 |
| Indirect Additives used in Food Contact Substances | TETRAKIS(HYDROXYMETHYL)PHOSPHONIUM SULFATE |
| CAS DataBase Reference | 55566-30-8(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 5I8RSL9E6S |
| EPA Substance Registry System | Tetrakis(hydroxymethyl)phosphonium sulfate (55566-30-8) |
| UNSPSC Code | 12352000 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H317-H318-H331-H350-H412 | |||||||||
| Precautionary statements | P273-P280-P301+P312-P304+P340+P311-P305+P351+P338-P308+P313 | |||||||||
| Hazard Codes | C,N,T | |||||||||
| Risk Statements | 22-34-43-50-41-20/22-45 | |||||||||
| Safety Statements | 26-36/37/39-45-61-53 | |||||||||
| RIDADR | UN 2922 8/PG 3 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | TA2570000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29319019 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Inhalation Acute Tox. 4 Oral Aquatic Chronic 3 Carc. 1B Eye Dam. 1 Skin Sens. 1 |
|||||||||
| Hazardous Substances Data | 55566-30-8(Hazardous Substances Data) | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Tetrakis(hydroxymethyl)phosphonium sulfate price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 15175 | Bis[tetrakis(hydroxymethyl)phosphonium] sulfate solution technical, 70-75% in H2O (T) | 55566-30-8 | 250ml | $101 | 2026-04-30 | Buy |
| TCI Chemical | T1089 | Tetrakis(hydroxymethyl)phosphonium Sulfate (ca. 70-80% in Water) | 55566-30-8 | 25g | $29 | 2026-04-30 | Buy |
| TCI Chemical | T1089 | Tetrakis(hydroxymethyl)phosphonium Sulfate (ca. 70-80% in Water) | 55566-30-8 | 500g | $132 | 2026-04-30 | Buy |
| Chem-Impex | 36258 | Bis[tetrakis(hydroxymethyl)phosphonium] sulfate solution, 70-75% in H2O 90-105%(Assaybytitration) | 55566-30-8 | 250ML | $106.8 | 2026-05-19 | Buy |
| Matrix Scientific | 099533 | Tetrakis(hydroxymethyl)phosphonium sulfate (75% aqueous solution) | 55566-30-8 | 5.00g | $10 | 2026-05-18 | Buy |
Tetrakis(hydroxymethyl)phosphonium sulfate Chemical Properties, Uses, Production
Description
Tetrakis(hydroxymethyl)phosphonium sulfate (THPS) is an organophosphorus compound. It is used as a precursor in the flame retardant manufacturing process, a biocide in water systems, and a tanning agent in the leather industry. THPS is a safe aqueous solution with antimicrobial properties that is significantly less toxic, effective at lower concentrations, and more biodegradable than other traditional biocides.
Uses
Tetrakis(hydroxymethyl)phosphonium sulfate is a green and environmentally friendly quaternary phosphonium salt bactericide, mainly used as a biocidal agent. It is widely used in water treatment, oil fields, papermaking and other industries. Its outstanding advantage is that it can be rapidly degraded into completely harmless substances after use, greatly reducing the environmental impact of these industries. It is also an internationally recognized permanent flame retardant for pure cotton and polyester-cotton fabrics.
General Description
Clear colorless viscous liquid.
Air & Water Reactions
Water soluble.
Reactivity Profile
Tetrakis(hydroxymethyl)phosphonium sulfate is incompatible with oxidizing materials and alkalis.
Fire Hazard
Tetrakis(hydroxymethyl)phosphonium sulfate is probably combustible.
Flammability and Explosibility
Non flammable
Synthesis
Add sulfuric acid and formaldehyde into the reaction kettle, open the gas-liquid circulation mixing reaction pump, add phosphine into the gas-liquid circulation mixing reaction pump, at 50-60 through the gas-liquid circulation mixing reaction device to absorb phosphine, phosphine is not completely absorbed into the next gas-liquid circulation mixing reaction pump (the two gas-liquid circulation mixing reaction device is the same, just connected in series, so that it is more conducive to the use of phosphine), the reaction end point is determined by the central control detection of formaldehyde content, and then concentrated by decompression to get tetrahydroxymethylphosphine sulfate. Detect the content of formaldehyde through the central control to determine the end point of the reaction, after the end of the reaction by decompression and concentration to get tetrakis(hydroxymethyl)phosphine sulfate.
Advantages
Advantage of the wet white tanned leathers, using THPS offers:
a light color and pastel shades
They can reach shrink temperatures of at least 70 grad C
High softness
Good lightness
Feeling of naturalness
Pleasant to the touch
Beauty that lasts for a long time
Can be burned without the risk of hexavalent chromium formation
Tetrakis(hydroxymethyl)phosphonium sulfate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Wald Chemical Co., Ltd. | 0531-88773586 13210588999 | 304264064@qq.com | China | 192 | 58 |
| Shandong Shengteng Chemical Co., Ltd | 13688633386 15866781319 | 13688633386@163.cn | China | 500 | 58 |
| Jinan Yongchang Fuxiang Chemical Co., Ltd | 18253123678 | 315653877@qq.com | China | 87 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9409 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Secco work (Beijing) chemical technology co., LTD | 0566-8928158 | 343367102@QQ.COM | China | 359 | 54 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
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- Sep 12,2025
View Latest Price from Tetrakis(hydroxymethyl)phosphonium sulfate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-25 | Tetrakis(hydroxymethyl)phosphonium sulfate
55566-30-8
|
$1.00 | 1g | 0.99 | 20 tons | RongNa Biotechnology Co.,Ltd | |
 |
2026-09-24 | Tetrakis(hydroxymethyl)phosphonium sulfate
55566-30-8
|
$1.00 | 1kg | 99% | 5000mt | Jinan Finer Chemical Co., Ltd | |
 |
2026-09-24 | Tetrakis(hydroxymethyl)phosphonium sulfate
55566-30-8
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- Tetrakis(hydroxymethyl)phosphonium sulfate
55566-30-8
- $1.00
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Tetrakis(hydroxymethyl)phosphonium sulfate
55566-30-8
- $1.00
- 99%
- Jinan Finer Chemical Co., Ltd
-
- Tetrakis(hydroxymethyl)phosphonium sulfate
55566-30-8
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
