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Tris Base

Chemical Properties Uses of Biology Uses
Tris Base
Tris Base structure
CAS No.
77-86-1
Chemical Name:
Tris Base
Synonyms
THAM;TRIS;Trizma;Tham-E;TRISMAT;8VTE 1L;riladyl;thamset;Trisamin;NSC-6365
CBNumber:
CB8336488
Molecular Formula:
C4H11NO3
Formula Weight:
121.14
MOL File:
77-86-1.mol

Tris Base Properties

Melting point:
167-172 °C(lit.)
Boiling point:
219-220 °C10 mm Hg(lit.)
Density 
1,353 g/cm3
vapor pressure 
0.0267 hPa (20 °C)
refractive index 
1.4170 (estimate)
Flash point:
219-220°C/10mm
storage temp. 
2-8°C
solubility 
H2O: 4 M at 20 °C, clear, colorless
form 
crystalline
color 
white
PH
10.5-12.0(4 m in water, 25 °C)
PH Range
7 - 9
pka
8.1(at 25℃)
Water Solubility 
550 g/L (25 ºC)
λmax
λ: 260 nm Amax: 0.10
λ: 280 nm Amax: 0.08
Sensitive 
Hygroscopic
Merck 
14,9772
BRN 
741883
Stability:
Stable. Incompatible with bases, strong oxidizing agents. Protect from moisture.
InChIKey
LENZDBCJOHFCAS-UHFFFAOYSA-N
CAS DataBase Reference
77-86-1(CAS DataBase Reference)
EWG's Food Scores
1-2
FDA UNII
023C2WHX2V
NIST Chemistry Reference
1,3-Propanediol, 2-amino-2-(hydroxymethyl)-(77-86-1)
EPA Substance Registry System
Tris(hydroxymethyl)aminomethane (77-86-1)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P280-P304+P340+P312-P305+P351+P338-P337+P313-P261-P280a-P304+P340-P405-P501a-P264-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39-24/25-23
WGK Germany  2
RTECS  TY2900000
3
TSCA  Yes
HazardClass  IRRITANT
HS Code  29221980
Toxicity LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rat > 5000 mg/kg
NFPA 704
1
2 1

Tris Base price More Price(176)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T1699 Trizma® base solution 1.5?M 100 mL $36.8 2021-03-22 Buy
Sigma-Aldrich T6066 Trizma® base BioPerformance Certified, meets EP, USP testing specifications, suitable for cell culture, ≥99.9% (titration) 100 g $46.1 2021-03-22 Buy
Sigma-Aldrich 252859 Tris(hydroxymethyl)aminomethane ACS reagent, ≥99.8% 77-86-1 100g $45 2021-03-22 Buy
Sigma-Aldrich 93350 Trizma® base puriss. p.a., ≥99.7% (T) 100 g $81.2 2021-03-22 Buy
Sigma-Aldrich 1.02408 Tris(hydroxymethyl)aminomethane volumetric standard, secondary reference material for acidimetry, traceable to NIST Standard Reference Material (SRM) Certipur? Reag. Ph Eur,Reag. USP 80 g $96.2 2021-03-22 Buy

Tris Base Chemical Properties,Uses,Production

Chemical Properties

White crystal or powder. Melting point 171-172℃, boiling point 219-220℃/1.3kPa, soluble in ethanol and water, slightly soluble in ethyl acetate, benzene, insoluble in ether, carbon tetrachloride,copper,aluminum corrosion effects,irritant.

Uses of Biology

Tris base, also known as THAM, is widely used as a biological buffer or as a component of buffer formulations such as TAE and TBE buffers. Tris has a pKa of 8.06 and is very useful in the biology and biochemistry lab because it has buffering capabilities in the range of the typical physiological pH of most living organisms (pH 7.0-9.0). Tris has been reported to interfere with the activity of a number of enzymes, it should therefore be used carefully when studying proteins.

Uses

1, Tris buffer, only nucleic acids and proteins are widely used as solvents.
2, Tris is used for protein crystal growth under different pH conditions.
3, Tris buffer having a low ionic strength can be used nematode (C. elegans) is formed lamin (lamin) intermediate fibers.
4, Tris is a major component of protein electrophoresis buffer.
5, Tris for the preparation of a surfactant, a vulcanization accelerator, and some drug intermediates.
6, Tris titrated also used as standard.

Chemical Properties

White, crystalline solid. PH (0.1M aqueous solution) 10.6, corrosive to copper, brass, aluminum. Solubility in water 80 g/100 cc (20C). Combustible.

Originator

Trisaminol,Bellon,France,1964

Uses

tromethamine can help mask odor in a formulation. It is also used as a buffer, keeping product pH stable.

Uses

In the synthesis of surface-active agents, vulcanization accelerators, pharmaceuticals. As emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, leather dressings, textile specialties, polishes, cleaning Compounds, so-called soluble oils. Absorbent for acidic gases. Biological buffer.

Manufacturing Process

Nitromethane is reacted with formaldehyde to give tris(hydroxymethyl)nitromethane in an initial step. This intermediate may be reduced by catalytic hydrogenation (US Patent 2,174,242) or by electrolytic reduction (US Patent 2,485,982).

brand name

Tham (Hospira).

Therapeutic Function

Antacid

Biological Activity

Commonly used laboratory reagent

Purification Methods

TRIS can ordinarily be obtained in highly pure form suitable for use as an acidimetric standard. If only impure material is available, it should be crystallised from 20% EtOH, aqueous MeOH (m 171.1o) or isopropanol (m 172-173o). Dry it in a vacuum desiccator over P2O5 or CaCl2. Alternatively, it is dissolved in twice its weight of water at 55-60o, filtered, concentrated to half its volume and poured slowly, with stirring, into about twice its volume of EtOH. The crystals which separate on cooling to 3-4o are filtered off, washed with a little MeOH, air dried by suction, then finally ground and dried in a vacuum desiccator over P2O5. It has also been recrystallised from water, MeOH or aqueous MeOH, and vacuum dried at 80o for 2 days. [Beilstein 4 H 303, 4 III 857, 4 IV 1903.]

Tris Base Preparation Products And Raw materials

Raw materials

Preparation Products


Tris Base Suppliers

Global( 667)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Yunbio Tech Co.,Ltd.
010-60605551
010-60605551 yunbiochem@126.com CHINA 258 58
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2813 55
Jinan Qinmu Fine Chemical Co.,Ltd.
18660799346 18363098612
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Hubei Xindesheng Material Technology Co., Ltd.
18971041571 +86-15071057538
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Jinan Finer Chemical Co., Ltd
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+86-531-88989539 sales@finerchem.com CHINA 1011 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20010 60
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0371-55170693
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+8618017249410 +86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55

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View Lastest Price from Tris Base manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-11-11 Trometamol
77-86-1
US $0.00 / Kg/Drum 1KG 99% 200mt Jinan Finer Chemical Co., Ltd
2021-06-22 Trometamol
77-86-1
US $10.00 / KG 1KG ≥99% 10000kg Shijiazhuang Erche Biotechnology Co., Ltd
2021-06-07 Tris Base
77-86-1
US $47.50 / ASSAYS 1KG 99% 100kg Baoji Guokang Bio-Technology Co., Ltd.

Tris Base Spectrum


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