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SL0101

SL0101 structure

CAS No.: 77307-50-7

Chemical Name:: SL0101

Synonyms: SL0101;SL 0101-1;RSK Inhibitor, SL0101;3'',4''-Di-O-acetylafzelin;SL-0101-1;SL0101-1;SL-0101;SL 0101;SL0101;SL0101 1;Kaempferol 3-O-(3'',4''-di-O-acetyl-alpha-L-rhamnopyranoside);3-(3-O,4-O-Diacetyl-α-L-rhamnopyranosyloxy)-4',5,7-trihydroxyflavone;3-[(3-O,4-O-Diacetyl-6-deoxy-α-L-mannopyranosyl)oxy]4',5,7-trihydroxyflavone;2-(4-Hydroxyphenyl)-4-oxo-5,7-dihydroxy-4H-1-benzopyran-3-yl 3-O,4-O-diacetyl-α-L-rhamnopyranoside;2-(4-Hydroxyphenyl)-3-(3-O,4-O-diacetyl-α-L-rhamnopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one

CBNumber:: CB8507631

Molecular Formula:: C25H24O12

Molecular Weight:: 516.45

MDL Number:: MFCD09842349

MOL File:: 77307-50-7.mol

Last updated:2023-06-30 15:45:59

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SL0101 Properties

Melting point	128-132°C
Boiling point	753.0±60.0 °C(Predicted)
Density	1.57±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Acetone (Slightly), Methanol (Slightly)
form	Yellow solid
pka	6.20±0.40(Predicted)
color	Pale Yellow to Brown

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338
HS Code	2940000080

SL0101 price More Price(18)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	559285	RSK Inhibitor, SL0101	77307-50-7	1mg	$360	2024-03-01	Buy
Cayman Chemical	11704	SL 0101-1 ≥98%	77307-50-7	500μg	$57	2024-03-01	Buy
Cayman Chemical	11704	SL 0101-1 ≥98%	77307-50-7	1mg	$100	2024-03-01	Buy
Cayman Chemical	11704	SL 0101-1 ≥98%	77307-50-7	5mg	$395	2024-03-01	Buy
Cayman Chemical	11704	SL 0101-1 ≥98%	77307-50-7	10mg	$547	2024-03-01	Buy

Product number	Packaging	Price	Buy
559285	1mg	$360	Buy
11704	500μg	$57	Buy
11704	1mg	$100	Buy
11704	5mg	$395	Buy
11704	10mg	$547	Buy

SL0101 Chemical Properties,Uses,Production

Description

The p90 ribosomal S6 kinases (RSK) 1-4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. SL 0101-1 is a kaempferol glycoside, isolated from the tropical plant F. refracta, that selectively inhibits RSK2 with an IC₅₀ value of 89 nM (K_i = 1 μM) without interfering with upstream activators of RSK, including ERK, MEK, EGFR, and PKC. At 100 μM, SL 0101-1 inhibits the proliferation of MCF-7 breast cancer cells, arresting cells in the G₁ phase of the cell cycle. SL 0101-1 has been used to characterize the intracellular signaling events associated with angiotensin II-induced tyrosine kinase activation with a concentration of 30 μM attenuating angiotensin II-induced cell proliferation.

Chemical Properties

Tan Solid

Uses

SL 0101 is a potent and selective inhibitor of p90 Rsk, without inhibiting the function of upstream kinases such as MEK, Raf, or PKC.

Biological Activity

Selective inhibitor of p90 ribosomal S6 kinase (RSK) (IC 50 = 89 nM for RSK2). Does not inhibit upstream kinases such as MEK, Raf and PKC.? Inhibits the growth of MCF-7 human breast cancer cells with no effect on the normal breast cell line.

storage

-20°C

SL0101 Preparation Products And Raw materials

Raw materials

Preparation Products

SL0101 Suppliers

Global( 76)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33349	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2923	55
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32344	50

Supplier	Advantage
BOC Sciences	58
TargetMol Chemicals Inc.	58
InvivoChem	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58
Shanghai Boyle Chemical Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chemsky（shanghai）International Co.,Ltd.	50

77307-50-7(SL0101)Related Search:

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SL0101

1of2

3-[(3,4-Di-O-acetyl-6-deoxy-α-L-Mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one Kaempferol 3-O-(3'',4''-di-O-acetyl-alpha-L-rhamnopyranoside) SL0101 2-(4-Hydroxyphenyl)-3-(3-O,4-O-diacetyl-α-L-rhamnopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one 2-(4-Hydroxyphenyl)-4-oxo-5,7-dihydroxy-4H-1-benzopyran-3-yl 3-O,4-O-diacetyl-α-L-rhamnopyranoside 3-(3-O,4-O-Diacetyl-α-L-rhamnopyranosyloxy)-4',5,7-trihydroxyflavone 3-[(3-O,4-O-Diacetyl-6-deoxy-α-L-mannopyranosyl)oxy]4',5,7-trihydroxyflavone SL 0101-1 3-[(3,4-Di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydro-2-(4-hydroxyphenyl)-4H-1benzopyran-4-one 3'',4''-Di-O-acetylafzelin SL-0101-1;SL0101-1;SL-0101;SL 0101;SL0101;SL0101 1 RSK Inhibitor, SL0101 4H-1-Benzopyran-4-one, 3-[(3,4-di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)- (2S,3S,4S,5R,6S)-6-((5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl)oxy)-5-hydroxy-2-methyltetrahydro-2H-pyran-3,4-diyl diacetate 77307-50-7 13C & 2H Sugars Carbohydrates & Derivatives Inhibitors