SM-276001
- CAS No.
- 473930-22-2
- Chemical Name:
- SM-276001
- Synonyms
- SM-276001;SM-276001, 10 mM in DMSO;8H-Purin-8-one, 6-amino-2-(butylamino)-7,9-dihydro-9-[(6-methyl-3-pyridinyl)methyl]-;immune,SM-276001,IFNAR,Interferon-alpha/beta receptor,IFN,Toll-like Receptor (TLR),SM276001,inhibit,TLR7,Inhibitor,Interferon-α/β receptor,interferon,SM 276001,antitumor
- CBNumber:
- CB86215158
- Molecular Formula:
- C16H21N7O
- Molecular Weight:
- 327.38
- MDL Number:
- MFCD32701915
- MOL File:
- 473930-22-2.mol
SM-276001 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0082346 | SM-276001 99.71% | 473930-22-2 | 5mg | $350 | 2021-12-16 | Buy |
| ChemScene | CS-0082346 | SM-276001 99.71% | 473930-22-2 | 10mg | $580 | 2021-12-16 | Buy |
| ChemScene | CS-0082346 | SM-276001 99.71% | 473930-22-2 | 50mg | $1650 | 2021-12-16 | Buy |
| ChemScene | CS-0082346 | SM-276001 99.71% | 473930-22-2 | 100mg | $2450 | 2021-12-16 | Buy |
SM-276001 Chemical Properties,Uses,Production
Description
SM-276001 is a selective and potent TLR7 agonist. SM-276001 is can induce antitumor immune responses when dosed either intratracheally or orally. Oral administration of SM-276001 leads to the induction of IFNα, TNFα and IL-12p40 and a reduction in tumor burden in the Balb/c syngeneic Renca and CT26 models.
Uses
SM-276001 is a potent selective TLR7 agonist that can induce antitumor immune responses. SM-276001 is an orally active interferon (IFN) inducer[1][2].
in vivo
SM-276001 demonstrates potent IFN-inducing activity at a dose of 0.1 mg/kg by oral administration in mice[1].
Oral administration of SM-276001, leads to the induction of an inflammatory cytokine and chemokine milieu and to the activation of a diverse population of immune effector cells including T and B lymphocytes, NK and NKT cells[2].
SM-276001 (3 mg/kg PO biweekly) significantly inhibits tumor growth in the Renca renal cell cancer and CT26 colorectal models[2].
SM-276001 (orally; 0.1, 1 or 10 mg/kg) leads to the activation of a diverse population of spleen-resident immune effector cells in Balb/c and C57BL/6J mice. When administered at 1 mg/kg or greater, the plasma concentration of SM-276001 exceeds the MEC of 30 nM[2].
| Animal Model: | C57BL/6 and B6C3F1 mice bearing Renca or CT26 tumors[2] |
| Dosage: | 3 mg/kg |
| Administration: | Oral administration twice weekly for 25 days |
| Result: | Significantly reduced disease burden in mice bearing either Renca or CT26 tumors. |
References
[1] Isobe Y, et al. Synthesis and biological evaluation of novel 9-substituted-8-hydroxyadenine derivatives as potent interferon inducers. J Med Chem. 2006 Mar 23;49(6):2088-95. DOI:10.1021/jm051089s
[2] Koga-Yamakawa E, et al. Intratracheal and oral administration of SM-276001: a selective TLR7 agonist, leads to antitumor efficacy in primary and metastatic models of cancer. Int J Cancer. 2013 Feb 1;132(3):580-90. DOI:10.1002/ijc.27691
SM-276001 Preparation Products And Raw materials
Raw materials
Preparation Products
SM-276001 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32239 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38648 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 3961 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71829 | 60 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2991 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10523 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24739 | 58 |
