(4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone
- CAS No.
- 432020-20-7
- Chemical Name:
- (4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone
- Synonyms
- SMI481;NPPM6748481;NPPM 6748481;NPPM-6748-481;NPPM 6748-481;SID: 164348711;SMI-481 SMI 481;SMI481, 10 mM in DMSO;Inhibitor,SMI481,SMI-481,inhibit;1-(4-Chloro-3-nitrobenzoyl)-4-(2-fluorophenyl)-piperazine
- CBNumber:
- CB52715743
- Molecular Formula:
- C17H15ClFN3O3
- Molecular Weight:
- 363.7707032
- MDL Number:
- MFCD03575351
- MOL File:
- 432020-20-7.mol
| Product description | Number | Pack Size | Price |
| SMI481 ≥98% (HPLC) | SML1090 | 5mg | $102 |
| SMI481 ≥98% (HPLC) | SML1090 | 25mg | $410 |
| SMI-481 ≥98% | 17637 | 1mg | $32 |
| SMI-481 ≥98% | 17637 | 5mg | $93 |
| SMI-481 ≥98% | 17637 | 10mg | $169 |
| Boiling point | 543.3±50.0 °C(Predicted) |
|---|---|
| Density | 1.411±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble5mg/mL, clear |
| form | powder |
| pka | 1.04±0.10(Predicted) |
| color | white to beige |
| UNSPSC Code | 12352207 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
(4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1090 | SMI481 ≥98% (HPLC) | 432020-20-7 | 5mg | $102 | 2022-05-15 | Buy |
| Sigma-Aldrich | SML1090 | SMI481 ≥98% (HPLC) | 432020-20-7 | 25mg | $410 | 2022-05-15 | Buy |
| Cayman Chemical | 17637 | SMI-481 ≥98% | 432020-20-7 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 17637 | SMI-481 ≥98% | 432020-20-7 | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 17637 | SMI-481 ≥98% | 432020-20-7 | 10mg | $169 | 2024-03-01 | Buy |
(4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone Chemical Properties,Uses,Production
Uses
SMI-481 is a yeast phosphatidylinositol transfer proteins (PITP) Sec14 inhibitor.
Biological Activity
SMI481 is a selective small-molecule inhibitor (SMI) of the yeast phosphatidylinositol transfer protein (PITP) Sec14, a key regulator of phosphoinositide signaling, regulating membrane trafficking through the trans-Golgi network and endosomal systems. SMI481 has an IC50 value of 211 ± 19 nM in vitro against S. cerevisiae Sec14 (WT) in a phosphatidylinositol (PtdIns) transfer assay measuring exchange of PtdIns and phosphatidylcholine between membranes and inhibited Sec14-dependent growth of WT yeast with an IC50 of 2.87 ± 0.55 μM. SMI481μs activity is believed to involve binding in the Sec14 hydrophobic cavity, a new target for studying phosphoinositide signaling with more selectivity than th at afforded by lipid kinase–directed strategies.
(4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone Preparation Products And Raw materials
Raw materials
Preparation Products
(4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4720 | 55 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9248 | 55 | |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
