(2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER
- CAS No.
- 116026-98-3
- Chemical Name:
- (2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER
- Synonyms
- Zinc04352714;3-(BOC-AMINO)-2-BROMOPYRIDINE;2-BROMO-3-N-BOC-AMINOPYRIDINE;TERT-BUTYL 2-BROMOPYRIDIN-3-YLCARBAMATE;tert-butyl N-(2-broMopyridin-3-yl)carbaMate;tert-Butyl 2-bromopyridin-3-ylcarbamate ,97%;2-bromo-3-[N-(t-butyloxycarbonylamino]pyridine;2-Bromo-3[N-（tert-butyloxycar-bonyl)amino]pyridine;N-(2-bromo-3-pyridinyl)carbamic acid tert-butyl ester;(2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER
- CBNumber:
- CB8704971
- Molecular Formula:
- C10H13BrN2O2
- Molecular Weight:
- 273.13
- MDL Number:
- MFCD07367911
- MOL File:
- 116026-98-3.mol
| Melting point | 84-85°C |
|---|---|
| Boiling point | 298.9±25.0 °C(Predicted) |
| Density | 1.453±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | solid |
| pka | 12.00±0.70(Predicted) |
| Appearance | Off-white to light yellow Solid |
| UNSPSC Code | 12352106 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| Hazard Codes | Xi,Xn |
| Risk Statements | 22 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 29333990 |
(2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | ADE000357 | (2-Bromo-pyridin-3-yl)-carbamic acid tert-butyl ester Aldrich | 116026-98-3 | 1g | $497 | 2025-07-31 | Buy |
| TRC | T204853 | tert-Butyl2-Bromopyridin-3-ylcarbamate | 116026-98-3 | 50mg | $45 | 2021-12-16 | Buy |
| TRC | T204853 | tert-Butyl2-Bromopyridin-3-ylcarbamate | 116026-98-3 | 500mg | $285 | 2021-12-16 | Buy |
| Matrix Scientific | 023790 | (2-Bromo-pyridin-3-yl)-carbamic acidtert-butyl ester 97% | 116026-98-3 | 250mg | $73 | 2021-12-16 | Buy |
| Matrix Scientific | 023790 | (2-Bromo-pyridin-3-yl)-carbamic acidtert-butyl ester 97% | 116026-98-3 | 1g | $184 | 2021-12-16 | Buy |
(2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties,Uses,Production
Chemical Properties
White solid
Synthesis
39856-58-1
24424-99-5
116026-98-3
Step 1: Synthesis of tert-butyl 2-bromopyridin-3-ylcarbamate (10a) To a solution of 2-bromopyridin-3-amine (3.0 g, 17.3 mmol) in tetrahydrofuran (THF, 30 mL) was slowly added lithium bis(trimethylsilyl)carbamate (1M, 35 mL, 35 mmol) at 0 °C. The reaction mixture was stirred at this temperature for 30 minutes. Subsequently, a solution of di-tert-butyl dicarbonate (Boc2O, 3.9 g, 17.3 mmol) in THF (20 mL) was added and the mixture was stirred at room temperature for 1.5 hours. Upon completion of the reaction, the reaction mixture was poured into 0.1 M hydrochloric acid (HCl) and extracted with ethyl acetate (EA). The organic layers were combined, washed with saturated saline (brine), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography (CC, petroleum ether/ethyl acetate = 5/1) to afford the target compound 10a (2.9 g, 62% yield) as a white solid.
References
[1] Journal of Medicinal Chemistry, 2009, vol. 52, # 16, p. 5032 - 5043
[2] Patent: WO2013/64231, 2013, A1. Location in patent: Page/Page column 51
[3] Patent: US2013/131036, 2013, A1. Location in patent: Paragraph 1676; 1677
[4] Patent: WO2013/62966, 2013, A2. Location in patent: Paragraph 203; 204
[5] Patent: WO2005/21529, 2005, A1. Location in patent: Page/Page column 31
(2-BROMO-PYRIDIN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29731 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49733 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 19957148339; | market18@leapchem.com | China | 24727 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49983 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 |