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FURA-FF, AM

FURA-FF, AM Structure
FURA-FF, AM structure
CAS No.
348079-12-9
Chemical Name:
FURA-FF, AM
Synonyms
FURA-FF, AM;Fura-FF, AM [Fura-2FF, AM] *CAS 348079-12-9*;5-Oxazolecarboxylic acid, 2-[6-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-5-[2-[6-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-2,3-difluorophenoxy]ethoxy]-2-benzofuranyl]-, (acetyloxy)methyl ester
CBNumber:
CB8741336
Molecular Formula:
C43H43F2N3O24
Molecular Weight:
1023.8
MDL Number:
MFCD03456899
MOL File:
348079-12-9.mol
Last updated:2023-05-21 10:59:17
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FURA-FF, AM Properties

Boiling point 971.5±75.0 °C(Predicted)
Density 1.447±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: soluble
form A solid
pka 0.36±0.50(Predicted)

FURA-FF, AM price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 20416 Fura-FF AM ≥90% 348079-12-9 50μg $63 2024-03-01 Buy
Product number Packaging Price Buy
20416 50μg $63 Buy

FURA-FF, AM Chemical Properties,Uses,Production

Description

Fura-FF AM is a cell-permeable acetoxymethyl ester of the fluorescence calcium indicator fura-FF (potassium salt) . As fura-FF AM enters cells, it is hydrolyzed by intracellular esterases to produce fura-FF. Fura-FF is a difluorinated derivative of the calcium indicator fura-2 . Unlike, fura-2, fura-FF has negligible magnesium sensitivity, thus reducing interference from this cation.1 Fura-FF also has a higher calcium dissociation constant than fura-2 (Kd(calcium) = 6 and 0.14 μM, respectively).1,2 However, the spectral properties of fura-FF and fura-2 are similar with fura-FF displaying excitation/emission spectra of 365/514 nm in the absence of calcium, with a shift to 339/507 nm in the presence of a high calcium concentration.3 Low affinity calcium dyes, including fura-FF, are preferred for studying compartments with high concentrations of calcium, such as mitochondria, or in cell systems that have relatively low calcium buffering capacities, such as neuronal dendrites and spines.4,5,6

References

1. Hyrc, K.L., Bownik, J.M., and Goldberg, M.P. Ionic selectivity of low-affinity ratiometric calcium indicators: mag-Fura-2, Fura-2FF and BTC Cell Calcium 27(2),75-86(2000).
2. Grynkiewicz, G., Poenie, M., and Tsien, R.Y. A new generation of Ca2+ indicators with greatly improved fluorescence properties J. Biol. Chem. 260(6),3440-3450(1985).
3. Ruggiu, A.A., Bannwarth, M., and Johnsson, K. Fura-2FF-based calcium indicator for protein labeling Org. Biomol. Chem. 8(15),3398-3401(2010).
4. Aponte, Y., Bischofberger, J., and Jonas, P. Efficient Ca2+ buffering in fast-spiking basket cells of rat hippocampus J. Physiol. 586(8),2061-2075(2008).
5. Canepari, M., Vogt, K., and Zecevic, D. Combining voltage and calcium imaging from neuronal dendrites Cell. Mol. Neurobiol. 28(8),1079-1093(2008).
6. Marcu, R., Neely, C.K., Karamanlidis, G., et al. Multi-parameter measurement of the permeability transition pore opening in isolated mouse heart mitochondria J. Vis. Exp. 67:4131,(2012).

FURA-FF, AM Preparation Products And Raw materials

Raw materials

Preparation Products

FURA-FF, AM Suppliers

Global( 21)Suppliers
Supplier Tel Email Country ProdList Advantage
Alfa Chemistry 		+1-5166625404 Info@alfa-chemistry.com United States 21317 58
Beijing Ouhe Technology Co., Ltd 010-82967028 13552068683 2355560935@qq.com China 12458 60
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Absin Bioscience Inc. 021-38015121 15000105423 chenjw@absin.cn China 24734 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
Shanghai Yiyan Biotechnology Co. , Ltd. 021-69985186 13611928337 3427709316@qq.com China 7984 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.com China 24246 58
Supplier Advantage
Alfa Chemistry 		58
Beijing Ouhe Technology Co., Ltd 60
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Absin Bioscience Inc. 58
MedBioPharmaceutical Technology Inc 58
Shanghai Yiyan Biotechnology Co. , Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58

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FURA-FF, AM Fura-FF, AM [Fura-2FF, AM] *CAS 348079-12-9* 5-Oxazolecarboxylic acid, 2-[6-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-5-[2-[6-[bis[2-[(acetyloxy)methoxy]-2-oxoethyl]amino]-2,3-difluorophenoxy]ethoxy]-2-benzofuranyl]-, (acetyloxy)methyl ester 348079-12-9