4,5,6,7-TETRABROMOBENZOTRIAZOLE
- CAS No.
- 17374-26-4
- Chemical Name:
- 4,5,6,7-TETRABROMOBENZOTRIAZOLE
- Synonyms
- TBB;TBBT;NSC 231634;CK2 INHIBITOR;7-tetrabromo-;TBB(NSC 231634);YM905 free base;TBB (enzyMe inhibitor);4,5,6,7-Tetrabromotriazole;CASEIN KINASE II INHIBITOR I
- CBNumber:
- CB9104424
- Molecular Formula:
- C6HBr4N3
- Molecular Weight:
- 434.71
- MDL Number:
- MFCD06411399
- MOL File:
- 17374-26-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
WGK Germany | 3 |
HS Code | 29349990 |
4,5,6,7-TETRABROMOBENZOTRIAZOLE price More Price(40)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | T0826 | TBB ≥98% (HPLC), solid | 17374-26-4 | 10mg | $282 | 2024-03-01 | Buy |
Sigma-Aldrich | 218697 | Casein Kinase II Inhibitor I | 17374-26-4 | 10mg | $144 | 2024-03-01 | Buy |
TCI Chemical | T2920 | 4,5,6,7-Tetrabromobenzotriazole >97.0%(HPLC)(T) | 17374-26-4 | 10mg | $103 | 2022-04-27 | Buy |
TCI Chemical | T2920 | 4,5,6,7-Tetrabromobenzotriazole >97.0%(HPLC)(T) | 17374-26-4 | 50mg | $373 | 2024-03-01 | Buy |
Cayman Chemical | 14453 | TBB ≥98% | 17374-26-4 | 5mg | $38 | 2024-03-01 | Buy |
4,5,6,7-TETRABROMOBENZOTRIAZOLE Chemical Properties,Uses,Production
Chemical Properties
Crystalline Solid
Uses
TBB is one of the most selective protein kinase inhibitors known, and when tested against a panel of 33 serine/threonine and tyrosine protein kinases, only three exhibited moderate inhibition by TBB, with Ki values one to two orders of magnitude higher than that for CK2.
Uses
TBB is one of the most selective protein kinase inhibitors known, and when tested against a panel of 33 serine/threonine and tyrosine protein kinases, only three exhibited moderate inhibition by TBB, with Ki values one to two orders of magnitude higher than that for CK2.
Biological Activity
A cell-permeable, selective inhibitor of casein kinase-2 (CK2) (IC 50 = 0.9 and 1.6 μ M for rat liver and human recombinant CK2 respectively). Exhibits modest discrimination between CK2 subunits, with K i values ranging from 80 nM to 210 nM. Acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases.
Biochem/physiol Actions
TBB binds to the Val66 residue of casein kinase-2 and inhibits the binding of ATP/GTP. TBB is cell permeable; it induces caspase-dependent apoptosis and degrades hematopoietic lineage cell-specific protein 1 in Jurkat cells.
storage
Store at -20°C
4,5,6,7-TETRABROMOBENZOTRIAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
4,5,6,7-TETRABROMOBENZOTRIAZOLE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9821 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9991 | 58 |
PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | peter68@ptchemgroup.com | China | 35453 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
View Lastest Price from 4,5,6,7-TETRABROMOBENZOTRIAZOLE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-08-02 | 4,5,6,7-TETRABROMOBENZOTRIAZOLE
17374-26-4
|
US $1.00 / KG | 1KG | 95-99% | 500kg/month | Career Henan Chemical Co |
- 4,5,6,7-TETRABROMOBENZOTRIAZOLE
17374-26-4
- US $1.00 / KG
- 95-99%
- Career Henan Chemical Co