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4,5,6,7-TETRABROMOBENZOTRIAZOLE

4,5,6,7-TETRABROMOBENZOTRIAZOLE structure

CAS No.: 17374-26-4

Chemical Name:: 4,5,6,7-TETRABROMOBENZOTRIAZOLE

Synonyms: TBB;TBBT;NSC 231634;CK2 INHIBITOR;7-tetrabromo-;TBB(NSC 231634);YM905 free base;TBB (enzyMe inhibitor);4,5,6,7-Tetrabromotriazole;CASEIN KINASE II INHIBITOR I

CBNumber:: CB9104424

Molecular Formula:: C6HBr4N3

Molecular Weight:: 434.71

MDL Number:: MFCD06411399

MOL File:: 17374-26-4.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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4,5,6,7-TETRABROMOBENZOTRIAZOLE Properties

Melting point	262-266°C
Boiling point	552.5±45.0 °C(Predicted)
Density	2.840±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: 28 mg/mL
form	solid
pka	3.87±0.40(Predicted)
color	white
λmax	300nm(MeOH)(lit.)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
WGK Germany	3
HS Code	29349990

4,5,6,7-TETRABROMOBENZOTRIAZOLE price More Price(40)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T0826	TBB ≥98% (HPLC), solid	17374-26-4	10mg	$282	2024-03-01	Buy
Sigma-Aldrich	218697	Casein Kinase II Inhibitor I	17374-26-4	10mg	$144	2024-03-01	Buy
TCI Chemical	T2920	4,5,6,7-Tetrabromobenzotriazole >97.0%(HPLC)(T)	17374-26-4	10mg	$103	2022-04-27	Buy
TCI Chemical	T2920	4,5,6,7-Tetrabromobenzotriazole >97.0%(HPLC)(T)	17374-26-4	50mg	$373	2024-03-01	Buy
Cayman Chemical	14453	TBB ≥98%	17374-26-4	5mg	$38	2024-03-01	Buy

Product number	Packaging	Price	Buy
T0826	10mg	$282	Buy
218697	10mg	$144	Buy
T2920	10mg	$103	Buy
T2920	50mg	$373	Buy
14453	5mg	$38	Buy

4,5,6,7-TETRABROMOBENZOTRIAZOLE Chemical Properties,Uses,Production

Chemical Properties

Crystalline Solid

Uses

TBB is one of the most selective protein kinase inhibitors known, and when tested against a panel of 33 serine/threonine and tyrosine protein kinases, only three exhibited moderate inhibition by TBB, with Ki values one to two orders of magnitude higher than that for CK2.

Biological Activity

A cell-permeable, selective inhibitor of casein kinase-2 (CK2) (IC 50 = 0.9 and 1.6 μ M for rat liver and human recombinant CK2 respectively). Exhibits modest discrimination between CK2 subunits, with K i values ranging from 80 nM to 210 nM. Acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases.

Biochem/physiol Actions

TBB binds to the Val66 residue of casein kinase-2 and inhibits the binding of ATP/GTP. TBB is cell permeable; it induces caspase-dependent apoptosis and degrades hematopoietic lineage cell-specific protein 1 in Jurkat cells.

storage

Store at -20°C

4,5,6,7-TETRABROMOBENZOTRIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

4,5,6,7-TETRABROMOBENZOTRIAZOLE Suppliers

Global( 121)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
changzhou huayang technology co., ltd	+8615250961469	2571773637@qq.com	China	9821	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9991	58
PT CHEM GROUP LIMITED	+86-85511178 +86-85511178	peter68@ptchemgroup.com	China	35453	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58

Supplier	Advantage
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
changzhou huayang technology co., ltd	58
InvivoChem	58
Coresyn Pharmatech Co., Ltd.	58
PT CHEM GROUP LIMITED	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58

View Lastest Price from 4,5,6,7-TETRABROMOBENZOTRIAZOLE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-08-02	4,5,6,7-TETRABROMOBENZOTRIAZOLE 17374-26-4	US $1.00 / KG	1KG	95-99%	500kg/month	Career Henan Chemical Co

4,5,6,7-TETRABROMOBENZOTRIAZOLE
17374-26-4
US $1.00 / KG
95-99%
Career Henan Chemical Co

4,5,6,7-TETRABROMOBENZOTRIAZOLE Spectrum

4,5,6,7-TETRABROMOBENZOTRIAZOLE(17374-26-4)MS

17374-26-4(4,5,6,7-TETRABROMOBENZOTRIAZOLE)Related Search:

2-(2H-Benzothiazol-2-yl)-6-(dodecyl)-4-methylphenol Dibenzothiophene Centchroman CASEIN KINASE II 5-BROMO-1H-BENZOTRIAZOLE

4,5,6,7-TETRABROMOBENZOTRIAZOLE

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NSC 231634 TBB TBBT 4,5,6,7-Tetrabromo-1H-benzotriazole CASEIN KINASE II INHIBITOR *TBB** 4,5,6,7-Tetrabromo-2-azabenzimidazole, 4,5,6,7-Tetrabromobenzotriazole, NSC 231634, TBBt 1H-Benzotriazole, 4,5,6,7-tetrabroMo- TBB (enzyMe inhibitor) 4,5,6,7-TetrabroMo-1H-benzo[d][1,2,3]triazole TBB(NSC 231634) 4,5,6,7-TETRABROMO-2-AZABENZIMIDAZOLE 4,5,6,7-TETRABROMOBENZOTRIAZOLE CASEIN KINASE II INHIBITOR I CK2 INHIBITOR 4,5,6,7-Tetrabromotriazole 7-tetrabromo- NSC 231634; TBB (ENZYME INHIBITOR);1H-BENZOTRIAZOLE; 4;5;6;7-TETRABROMO- 4,5,6,7-tetrabromo-2H-benzotriazole 4,5,6,7-Tetrabromobenzotriazole, 97%, selective, cell-permeable casein kinase-2 (CK2) inhibitor YM905 free base 4,5,6,7-Tetrabromobenzotriazole, selective, cell-permeable casein kinase-2 (CK2) inhibitor 17374-26-4 35-95-2 C6HN3Br4 C6HBr4N3 Casein Kinase (CK) Cell Biology Cell Signaling and Neuroscience BioChemical Kinase/Phosphatase Biology Serine/Threonine Kinase Inhibitors Akt mTOR PI3K Inhibitors PI3K/Akt/mTOR Protein Kinase Protein Kinase Inhibitors and Activators