Phenactropinium chloride
- CAS No.
- 3784-89-2
- Chemical Name:
- Phenactropinium chloride
- Synonyms
- Phenactropinium;Phenactropinium chloride;3-[Hydroxy(phenyl)acetoxy]-8-methyl-8-(2-oxo-2-phenylethyl)-8-azoniabicyclo[3.2.1]octane;(8-methyl-8-phenacyl-8-azoniabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenylacetate chloride;(8-methyl-8-phenacyl-8-azoniabicyclo[3.2.1]octan-3-yl) 2-hydroxy-2-phenyl-ethanoate chloride;2-hydroxy-2-phenyl-acetic acid (8-methyl-8-phenacyl-8-azoniabicyclo[3.2.1]octan-3-yl) ester chloride
- CBNumber:
- CB91116431
- Molecular Formula:
- C24H28ClNO4
- Molecular Weight:
- 0
- MDL Number:
- MFCD00865797
- MOL File:
- 3784-89-2.mol
| Melting point | 195-197° |
|---|---|
| FDA UNII | 43P9Q83UFF |
Phenactropinium chloride Chemical Properties,Uses,Production
Originator
Trophenium ,American Cyanamid (AHP), US ,1961
Manufacturing Process
330 g (1.2 M) of homatropine were dissolved in 1 liter of dry methyl ethyl ketone and gently refluxed on a water-bath during the gradual addition of a solution of 204 g (1.32 M) redistilled phenacyl chloride in 200 ml of the same solvent. After 10 to 15 minutes 1 g of previously prepared homatropine phenacyl chloride was added to avoid formation of a supersaturated solution of the quaternary compound. Reflux was continued for 9 hours, then the thick suspension was allowed to cool, filtered and washed with 200 ml methyl ethyl ketone to yield 490 g (95%) slightly creamy solid, MP 188°C to 191°C.
For purification the crude quaternary salt was dissolved in hot ethyl alcohol (2 ml/g) and warm dry acetone (8 ml/g) was stirred into the clear filtrate. On cooling, 387 g (78 % recovery) of a pure white powder, MP 195°C to 197°C, were obtained, in which the ionizable chlorine assayed at 99.7% of the theoretical value.
Therapeutic Function
Antihypertensive
Phenactropinium chloride Preparation Products And Raw materials
Phenactropinium chloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Leancare Ltd. | -- | enquiry@leancare.co.uk | United Kingdom | 6460 | 42 |
| Lanospharma Laboratories Co.,Ltd | -- | sales@lanospharma.com | China | 6343 | 56 |
| 2A PharmaChem USA | -- | sales@2apharmachem.com | United States | 6148 | 39 |
| 3B Scientific Corporation | -- | sales@3bsc.com | United States | 6744 | 47 |
| Supplier | Advantage |
|---|---|
| Leancare Ltd. | 42 |
| Lanospharma Laboratories Co.,Ltd | 56 |
| 2A PharmaChem USA | 39 |
| 3B Scientific Corporation | 47 |