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thioperamide maleate salt

CAS No.
148440-81-7
Chemical Name:
thioperamide maleate salt
Synonyms
MR-12842 maleate;N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt;MR-12842, N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt;1-Piperidinecarbothioamide, N-cyclohexyl-4-(1H-imidazol-4-yl)-, (2Z)-2-butenedioate (1:1);MR-12842,inhibit,Thioperamide maleate,MR 12842,MR12842,Histamine Receptor,Inhibitor,Thioperamide
CBNumber:
CB91216162
Molecular Formula:
C15H24N4SC4H4O4
Molecular Weight:
0
MDL Number:
MFCD00083209
MOL File:
148440-81-7.mol
Last updated:2023-09-04 15:50:00

thioperamide maleate salt Properties

storage temp. desiccated under inert gas
solubility H2O: >10mg/mL
form solid
color white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
NFPA 704
0
2 0

thioperamide maleate salt price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T123 Thioperamide maleate salt solid 148440-81-7 10mg $78 2024-03-01 Buy
Sigma-Aldrich T123 Thioperamide maleate salt solid 148440-81-7 25mg $187.8 2024-03-01 Buy
Cayman Chemical 10011127 Thioperamide (maleate) ≥98% 148440-81-7 1mg $15 2024-03-01 Buy
Cayman Chemical 10011127 Thioperamide (maleate) ≥98% 148440-81-7 5mg $57 2024-03-01 Buy
Sigma-Aldrich T123 Thioperamide maleate salt solid 148440-81-7 100mg $950 2024-03-01 Buy
Product number Packaging Price Buy
T123 10mg $78 Buy
T123 25mg $187.8 Buy
10011127 1mg $15 Buy
10011127 5mg $57 Buy
T123 100mg $950 Buy

thioperamide maleate salt Chemical Properties,Uses,Production

Description

Thioperamide (maleate) is a selective histamine H3 receptor antagonist that crosses the blood-brain barrier. This compound binds to rat cerebral cortical cells in vitro with a pKi value of 8.4 and inhibits histamine binding in vivo with an ED50 value of 1 mg/kg. At a dose of 5 mg/kg thioperamide (maleate) inhibits kindled seizures in rats by decreasing histamine and gamma-aminobutyric acid.

Uses

Thioperamide maleate salt was used to study the sympathetic and autonomic nerve activity in mammalian white adipose tissue.

Biochem/physiol Actions

Thioperamide is a potent and selective H3 histamine receptor antagonist that crosses the blood-brain barrier. It affects the central histaminergic system and decreases the duration of seizures and convulsions in mice. It also improves learning deficit induced by other drugs such as scopolamine.

thioperamide maleate salt Preparation Products And Raw materials

Raw materials

Preparation Products

thioperamide maleate salt Suppliers

Global( 23)Suppliers
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TargetMol Chemicals Inc.
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LEAPCHEM CO., LTD.
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Aladdin Scientific
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Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
BOC Sciences 16314854226 info@bocsci.com United States 9926 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 8011 62
Aikon International Limited 025-66113011 18112977050 cb6@aikonchem.com China 15495 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58

thioperamide maleate salt Spectrum

MR-12842, N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt 1-Piperidinecarbothioamide, N-cyclohexyl-4-(1H-imidazol-4-yl)-, (2Z)-2-butenedioate (1:1) MR-12842 maleate MR-12842,inhibit,Thioperamide maleate,MR 12842,MR12842,Histamine Receptor,Inhibitor,Thioperamide 148440-81-7