CELECOXIB
- CAS No.
- 184007-95-2
- Chemical Name:
- CELECOXIB
- Synonyms
- Ccris 8679;Celecoxib [old rn]
- CBNumber:
- CB91267649
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- 184007-95-2.mol
CELECOXIB Chemical Properties,Uses,Production
Originator
Celact,Sun Pharmaceuticals Industries Ltd.,India
Definition
ChEBI: Celecoxib is a member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and p-tolyl groups, respectively. A cyclooxygenase-2 inhibitor, it is used in the treatment of arthritis. It has a role as a cyclooxygenase 2 inhibitor, a geroprotector, a non-steroidal anti-inflammatory drug and a non-narcotic analgesic. It is a member of toluenes, a sulfonamide, a member of pyrazoles and an organofluorine compound.
Manufacturing Process
4-(5-(4-Methylphenyl)-3-trifluoromethyl-N-pyrazol-1-yl)benzenesulfonamide To a solution of ethyl trifluoroacetate (1.90 ml, 16.0 mmol) in 7 ml of methyl tert-butyl ether was added 25% NaOMe (3.62 ml, 16.8 mmol). Next 4- chloroaceteophenone (2.08 ml, 16.0 mmol) in 2 ml of methyl tert-butyl ether was added. The mixture was stirred at room temperature overnight. To above solution was added 100 ml of 90% EtOH, followed by 4 N HCl (4.0 ml, 16 mmol) and 4-sulphonamidophenylhydrazine hydrochloride (3.58 g, 16 mmol). The mixture was heated to reflux for 3 hours. The mixture was concentrated. When 30 ml of water was added, a solid formed. The solid was filtered and washed with 20 ml of 60% EtOH to give 4.50 g of white solid. The filtrate was evaporated and taken up in ethyl acetate (100 ml), washed with saturated NaHCO3, and brine, dried over MgSO4, and concentrated. Heptane was added at boiling point of the mixture. After cooling down to 0°C, 1.01 g more product was obtained. The combined yield of the 4-(5-(4-methylphenyl)-3- trifluoromethyl-N-pyrazol-1-yl)benzenesulfonamide (Celecoxib) was 86%.
Therapeutic Function
Antiinflammatory
CELECOXIB Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
Changzhou AniKare Pharmatech Co., Ltd. | +86-0519-8359-8696 +8618018249389 | sales@anikare.com | China | 9259 | 58 |
China Nobel Chem Co., Limited | +86(0)21 60484900 | China | 764 | 50 | |
Credit Asia Chemical Co., Ltd. | +86 (21) 61124340 | China | 9767 | 58 | |
Nanjing crow LuNing pharmaceutical technology co., LTD | 13382066392 | CHINA | 4880 | 58 | |
Shanghai Han-Xiang Chemical Co., Ltd. | 15971444841 | amber@biochempartner.com | China | 3063 | 58 |
Wuhan kemike Biomedical Technology Co., Ltd | 13163388153 13163388153 | yeqiu416@163.com | China | 9936 | 58 |
Zhongxin Chenshi (Wuhan) Technology Co., Ltd | 18942922096 | 2662561040@qq.com | China | 1001 | 58 |
Hubei Hicks Biochemical Co., Ltd | 17362916295; 17362916295 | w17362916295@163.com | China | 4054 | 58 |