Guan-fu base A
- CAS No.
- 1394-48-5
- Chemical Name:
- Guan-fu base A
- Synonyms
- Guan-fu A;Acehytisine;guan-fu base;Kwan-fu base A;Guan-fu base A;Guan-fu base A USP/EP/BP;(2α,11α,13R)-Hetisan-2,11,13,14-tetrol 2,11-diacetate;Hetisan-2,11,13,14-tetrol,2,13-diacetate, (2a,11a,13R)-;Hetisan-2,11,13,14-tetrol, 2,13-diacetate, (2α,11α,13R)-;(2alpha,11alpha,13R)-Hetisan-2,11,13,14-tetrol 2,13-diacetate
- CBNumber:
- CB91341165
- Molecular Formula:
- C24H31NO6
- Molecular Weight:
- 429.51
- MDL Number:
- MFCD32220461
- MOL File:
- 1394-48-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| GUAN-FU BASE A 95.00% | CBL0000907 | 5MG | $498.1 |
| Guan-fu base A | 2709 | 10mg | $590 |
| Guan-fubaseA | SY232803 | 10mg | $381.82 |
| Guan-fu base A | 2709 | 5mg | $390 |
| More product size | |||
| Boiling point | 541.5±50.0 °C(Predicted) |
|---|---|
| Density | 1.43±0.1 g/cm3(Predicted) |
| storage temp. | 4°C, away from moisture and light |
| pka | 12.97±0.70(Predicted) |
| form | Solid |
| color | White to off-white |
| InChIKey | OGNUSOJAYIHLNS-UFZRWAKRNA-N |
| SMILES | O[C@]12[C@@H]([C@]3([H])C(=C)CC41C[C@@]1([H])[C@]5([H])[C@]6(C[C@H](OC(=O)C)C[C@]5([C@]4([H])[C@@H]3O)C2N1C6)C)OC(=O)C |&1:1,2,3,10,12,14,16,22,23,25,r| |
| FDA UNII | A4KU64WAU2 |
Guan-fu base A price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | CBL0000907 | GUAN-FU BASE A 95.00% | 1394-48-5 | 5MG | $498.1 | 2021-12-16 | Buy |
| AvaChem | 2709 | Guan-fu base A | 1394-48-5 | 10mg | $590 | 2021-12-16 | Buy |
| Arctom | SY232803 | Guan-fubaseA | 1394-48-5 | 10mg | $381.82 | 2021-12-16 | Buy |
| AvaChem | 2709 | Guan-fu base A | 1394-48-5 | 5mg | $390 | 2021-12-16 | Buy |
Guan-fu base A Chemical Properties,Uses,Production
Chemical Properties
White crystals, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from the tuberous root of Aconitum carmichaelii (Kanbaifu), a plant of the Ranunculaceae family.
Uses
Guanfu base A is an antiarrhythmic alkaloid isolated from Aconitum coreanum and is a potent noncompetitive CYP2D6 inhibitor, with a Ki of 1.20 μM in human liver microsomes (HLMs) and a Ki of 0.37 μM for the human recombinant form (rCYP2D6). Guanfu base A is also a potent competitive inhibitor of CYP2D in monkey (Ki of 0.38 μM) and dog (Ki of 2.4 μM) microsomes[1]. Guanfu base A also inhibits HERG channel current[2].
in vivo
Beagle dogs treated intravenously with Dextromethorphan (2 mg/mL) after pretreatment with Guanfu base A injection shows reduced CYP2D metabolic activity, with the Cmax of dextrorphan being one-third that of the saline-treated group and area under the plasma concentration-time curve half that of the saline-treated group[1].
References
[1] Sun J, et al. Guanfu base A, an antiarrhythmic alkaloid of Aconitum coreanum, Is a CYP2D6 inhibitor of human, monkey, and dog isoforms. Drug Metab Dispos. 2015 May;43(5):713-24. DOI:10.1124/dmd.114.060905
[2] Huang X, et al. Comparative effects of Guanfu base A and Guanfu base G on HERG K+ channel. J Cardiovasc Pharmacol. 2012 Jan;59(1):77-83. DOI:10.1097/FJC.0b013e318236e380
Guan-fu base A Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3751 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 20010 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39042 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Mensura Group Limited | 18780014153 | 1058503172@qq.com | China | 2900 | 58 |
View Lastest Price from Guan-fu base A manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-01-13 | Guanfu base A
1394-48-5
|
US $57.00-202.00 / mg | 99.85% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Guan-fu base A
1394-48-5
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
-
- Guanfu base A
1394-48-5
- US $57.00-202.00 / mg
- 99.85%
- TargetMol Chemicals Inc.
-
- Guan-fu base A
1394-48-5
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
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