- Guanfu base A
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- $57.00 / 1mg
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2025-12-08
- CAS:1394-48-5
- Min. Order:
- Purity: 99.85%
- Supply Ability: 10g
- Guan-fu base A
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- $0.00 / 20mg
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2023-02-24
- CAS:1394-48-5
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
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| | Guan-fu base A Basic information |
| Product Name: | Guan-fu base A | | Synonyms: | Guan-fu base A;(2α,11α,13R)-Hetisan-2,11,13,14-tetrol 2,11-diacetate;(2alpha,11alpha,13R)-Hetisan-2,11,13,14-tetrol 2,13-diacetate;Acehytisine;Kwan-fu base A;Hetisan-2,11,13,14-tetrol, 2,13-diacetate, (2α,11α,13R)-;Hetisan-2,11,13,14-tetrol,2,13-diacetate, (2a,11a,13R)-;Guan-fu base A USP/EP/BP | | CAS: | 1394-48-5 | | MF: | C24H31NO6 | | MW: | 429.51 | | EINECS: | | | Product Categories: | | | Mol File: | 1394-48-5.mol |  |
| | Guan-fu base A Chemical Properties |
| Boiling point | 541.5±50.0 °C(Predicted) | | density | 1.43±0.1 g/cm3(Predicted) | | storage temp. | 4°C, away from moisture and light | | pka | 12.97±0.70(Predicted) | | form | Solid | | color | White to off-white | | InChIKey | OGNUSOJAYIHLNS-UFZRWAKRNA-N | | SMILES | O[C@]12[C@@H]([C@]3([H])C(=C)CC41C[C@@]1([H])[C@]5([H])[C@]6(C[C@H](OC(=O)C)C[C@]5([C@]4([H])[C@@H]3O)C2N1C6)C)OC(=O)C |&1:1,2,3,10,12,14,16,22,23,25,r| |
| | Guan-fu base A Usage And Synthesis |
| Chemical Properties | White crystals, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from the tuberous root of Aconitum carmichaelii (Kanbaifu), a plant of the Ranunculaceae family. | | Uses | Guanfu base A is an antiarrhythmic alkaloid isolated from Aconitum coreanum and is a potent noncompetitive CYP2D6 inhibitor, with a Ki of 1.20 μM in human liver microsomes (HLMs) and a Ki of 0.37 μM for the human recombinant form (rCYP2D6). Guanfu base A is also a potent competitive inhibitor of CYP2D in monkey (Ki of 0.38 μM) and dog (Ki of 2.4 μM) microsomes[1]. Guanfu base A also inhibits HERG channel current[2]. | | in vivo | Beagle dogs treated intravenously with Dextromethorphan (2 mg/mL) after pretreatment with Guanfu base A injection shows reduced CYP2D metabolic activity, with the Cmax of dextrorphan being one-third that of the saline-treated group and area under the plasma concentration-time curve half that of the saline-treated group[1]. | | References | [1] Sun J, et al. Guanfu base A, an antiarrhythmic alkaloid of Aconitum coreanum, Is a CYP2D6 inhibitor of human, monkey, and dog isoforms. Drug Metab Dispos. 2015 May;43(5):713-24. DOI:10.1124/dmd.114.060905
[2] Huang X, et al. Comparative effects of Guanfu base A and Guanfu base G on HERG K+ channel. J Cardiovasc Pharmacol. 2012 Jan;59(1):77-83. DOI:10.1097/FJC.0b013e318236e380 |
| | Guan-fu base A Preparation Products And Raw materials |
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