AGN 193109 (sodium salt)
- CAS No.
- 2319838-82-7
- Chemical Name:
- AGN 193109 (sodium salt)
- Synonyms
- AGN 193109 sodium;4-[2-[5,6-dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]-benzoicacid,monosodiumsalt
- CBNumber:
- CB913503313
- Molecular Formula:
- C28H25NaO2
- Molecular Weight:
- 416.5
- MDL Number:
- MOL File:
- 2319838-82-7.mol
| Product description | Number | Pack Size | Price |
| AGN 193109 (sodium salt) ≥98% | 23975 | 500 μg | $121 |
| AGN 193109 (sodium salt) ≥98% | 23975 | 1 mg | $230 |
AGN 193109 (sodium salt) Chemical Properties,Uses,Production
Uses
AGN 193109 sodium is the sodium salt form of AGN 193109 (HY-U00449). AGN 193109 sodium is the pan antagonist for retinoic acid receptor (RAR), with Kd of 2, 2 and 3 nM, for RARα, RARβ and RARγ, respectively. AGN 193109 sodium reverses TTNPB-induced morphology changes and all-trans retinoic acid (tRA)/9-cis RA/13-cis RA-induced proliferation suppression in ECE16-1 cell. AGN 193109 sodium is the antidote for retinoic acidosis, that ameliorates the skin and mucosal toxicity[1][2].
IC 50
RXR α: 2 nM (Kd); RXR β: 2 nM (Kd); RXR γ: 2 nM (Kd)
References
[1] Standeven AM, et al. Specific antagonist of retinoid toxicity in mice. Toxicol Appl Pharmacol. 1996 May;138(1):169-75. DOI:10.1006/taap.1996.0110
[2] Agarwal C, et al. AGN193109 is a highly effective antagonist of retinoid action in human ectocervical epithelial cells. J Biol Chem. 1996 May 24;271(21):12209-12. DOI:10.1074/jbc.271.21.12209
[3] D M KOCHHAR. The use of a retinoid receptor antagonist in a new model to study vitamin A-dependent developmental events.[J]. International Journal of Developmental Biology, 1998, 42 4: 601-608.
AGN 193109 (sodium salt) Preparation Products And Raw materials
Raw materials
Preparation Products
AGN 193109 (sodium salt) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29641 | 58 |
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 6838 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Cayman Chemical Company | 58 |
