holomycin
- CAS No.
- 488-04-0
- Chemical Name:
- holomycin
- Synonyms
- holomycin;N-Demethylthiolutin;N-(5-oxo-4H-dithiolo[4,3-b]pyrrol-6-yl)acetamide;N-(4,5-Dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide;Acetamide, N-(4,5-dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)-
- CBNumber:
- CB91367734
- Molecular Formula:
- C7H6N2O2S2
- Molecular Weight:
- 214.26
- MDL Number:
- MFCD01670588
- MOL File:
- 488-04-0.mol
- MSDS File:
- SDS
| Melting point | 268 °C (decomp) |
|---|---|
| Boiling point | 532.1±50.0 °C(Predicted) |
| Density | 1.63±0.1 g/cm3(Predicted) |
| solubility | DMSO, Methanol (Heated) |
| form | Solid |
| pka | 9.33±0.40(Predicted) |
| color | Brown-Orange |
| FDA UNII | 44CF65YLF8 |
holomycin price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | H458490 | Holomycin | 488-04-0 | 25mg | $1695 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 46485 | Holomycin | 488-04-0 | 50mg | $2200 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0013069 | HOLOMYCIN 95.00% | 488-04-0 | 5MG | $505.7 | 2021-12-16 | Buy |
holomycin Chemical Properties,Uses,Production
Uses
Holomycin-d3 is the isotope labelled analog of Holomycin (H458490); a member of the pyrrothine class of antibiotics that displays broad-spectrum antibacterial activity.
Definition
ChEBI: Holomycin is a dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 5 and 6 have been replaced by oxo and acetamido groups, respectively. It is an inhibitor of DNA-dependent RNA polymerase, and exhibits antibacterial and antitumour properties. It has a role as a chelator, an antineoplastic agent, an EC 2.7.7.6 (RNA polymerase) inhibitor, an antibacterial agent, a marine metabolite and a bacterial metabolite. It is a dithiolopyrrolone antibiotic and a member of acetamides.
Synthesis Reference(s)
Journal of the American Chemical Society, 86, p. 5654, 1964 DOI: 10.1021/ja01078a049
holomycin Preparation Products And Raw materials
Raw materials
Preparation Products
holomycin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
| Zhejiang Huida Biotech Co., LTD | 0571-89903882 13626641628 | jiangnan@huidabiotech.com | China | 3661 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-0571-89903882 15990081639 | sunshixuan@huidabiotech.com | China | 3705 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24024 | 58 |
| Hangzhou Huiyi Biotechnology Co., LTD | 0571-89918262 13357170655 | chenlingwei@hizyme.com | China | 556 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9146 | 58 |