ChemicalBook >> CAS DataBase List >>S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt

S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt

S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt structure

CAS No.: 136676-91-0

Chemical Name:: S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt

Synonyms: PD 123319 bis(trifluoroacetate);PD 123319 (trifluoroacetate salt);PD123319; PD-123319; S-+-PD 123319;PD 123319 DITRIFLUOROACETATE, CID: 6604951;PD 123,319 di(trifluoroacetate) salt hydrate;PD 123,319 hydrate di(trifluoroacetate) salt;PD 123,319 di(trifluoroacetate) salt hydrate powder, >=98% (HPLC);(S)-1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid bis(trifluoroacetate);S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid di(trifluoroacetate) salt hydrate;S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt

CBNumber:: CB92100002

Molecular Formula:: C33H33F3N4O5

Molecular Weight:: 622.65

MDL Number:: MFCD08276969

MOL File:: 136676-91-0.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt Properties

storage temp.	2-8°C
solubility	H2O: soluble10mg/mL, clear
form	powder
Water Solubility	Soluble to 100 mM in water

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

WGK Germany

NFPA 704

	0
2		0

S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	P186	PD 123,319 di(trifluoroacetate) salt hydrate powder, ≥98% (HPLC)	136676-91-0	10mg	$410	2024-03-01	Buy
Cayman Chemical	16099	PD 123319 (trifluoroacetate salt) ≥98%	136676-91-0	5mg	$97	2024-03-01	Buy
Cayman Chemical	16099	PD 123319 (trifluoroacetate salt) ≥98%	136676-91-0	10mg	$175	2024-03-01	Buy
Cayman Chemical	16099	PD 123319 (trifluoroacetate salt) ≥98%	136676-91-0	25mg	$385	2024-03-01	Buy
Cayman Chemical	16099	PD 123319 (trifluoroacetate salt) ≥98%	136676-91-0	50mg	$672	2024-03-01	Buy

Product number	Packaging	Price	Buy
P186	10mg	$410	Buy
16099	5mg	$97	Buy
16099	10mg	$175	Buy
16099	25mg	$385	Buy
16099	50mg	$672	Buy

S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt Chemical Properties,Uses,Production

Biological Activity

PD 123319 ditrifluoroacetate is a potent and selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.

in vitro

PD 123319 is shown to discriminate between two subclasses of AII receptors in many different tissues. ¹²⁵ I-AII specifically label two classes of binding sites for AII in a membrane preparation of bovine adrenal glomerulosa cells. The first class (DuP-753 sensitive) represents approximately 85% of the total binding sites for AII and possesses a high affinity (IC ₅₀ of 92.9 nM) for DuP-753. PD-123319 does not have any effect on ¹²⁵ I-AII binding to this site. The second class of binding sites is more sensitive to PD-123319, with an IC ₅₀ of 6.9 nM , and has a much lower affinity for DuP-753 (IC ₅₀ around 10 microM).

target

IC50: 34 nM (AT2 Receptor)

storage

Store at -20°C

S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt Preparation Products And Raw materials

Raw materials

Preparation Products

S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt Suppliers

Global( 62)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7553	61
TargetMol Chemicals Inc.	021-33632979 15002134094	marketing@targetmol.com	China	7934	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
InvivoChem	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Haoyuan Chemexpress Co., Ltd.	61
TargetMol Chemicals Inc.	58

View Lastest Price from S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-14	S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt 136676-91-0	US $9.80 / KG	1g	≥99%	100kg	Career Henan Chemical Co

S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt
136676-91-0
US $9.80 / KG
≥99%
Career Henan Chemical Co

S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt Spectrum

S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt(136676-91-0)¹HNMR

136676-91-0(S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt)Related Search:

(aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate Trifluoroacetic acid Pyridine trifluoroacetate Potassium phthalimide

(S)-1-[[4-(Dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid bis(trifluoroacetate) PD 123319 bis(trifluoroacetate) PD 123,319 hydrate di(trifluoroacetate) salt S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid hydrate di(trifluoroacetate) salt PD 123,319 di(trifluoroacetate) salt hydrate S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid di(trifluoroacetate) salt hydrate PD 123319 (trifluoroacetate salt) PD123319; PD-123319; S-+-PD 123319 PD 123319 DITRIFLUOROACETATE, CID: 6604951 PD 123,319 di(trifluoroacetate) salt hydrate powder, >=98% (HPLC) (S)-1-(4-(Dimethylamino)-3-methylbenzyl)-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid compound with 2,2,2-trifluoroacetic acid (1:2) 136676-91-0 C31H32N4O32C2HF3O2 C35H34F6N4O7