N-(1,3,4-Thiadiazolyl)nicotinamide
- CAS No.
- 51987-99-6
- Chemical Name:
- N-(1,3,4-Thiadiazolyl)nicotinamide
- Synonyms
- TGN-020;Nicotinamide Impurity 156;TGN 020;TGN-020;TGN020;51987-99-6;2-(Nicotinamide)-1,3,4-thiadiazole;N-(1,3,4-Thiadiazolyl)nicotinamide;N-(1,3,4-Thiadiazol-2-yl)nicotinamide;N-(1,3,4-Thiadiazolyl)-m-nicotinamide;TGN-020:2-(Nicotinamide)-1,3,4-thiadiazole;N-(1,3,4-Thiadiazol-2-yl)pyridine-3-carboxamide;N-(1,3,4-Thiadiazol-2-yl)-3-pyridinecarboxamide
- CBNumber:
- CB92511583
- Molecular Formula:
- C8H6N4OS
- Molecular Weight:
- 206.22
- MDL Number:
- MFCD00708771
- MOL File:
- 51987-99-6.mol
- MSDS File:
- SDS
Melting point | 291-293°C |
---|---|
Density | 1.500±0.06 g/cm3(Predicted) |
storage temp. | room temp |
solubility | DMSO: ≥8mg/mL |
pka | 6.78±0.50(Predicted) |
form | powder |
color | white to tan |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P280-P305+P351+P338 | |||||||||
Hazard Codes | Xn | |||||||||
Risk Statements | 22 | |||||||||
WGK Germany | 3 | |||||||||
NFPA 704 |
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N-(1,3,4-Thiadiazolyl)nicotinamide price More Price(12)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML0136 | TGN-020 ≥98% (HPLC) | 51987-99-6 | 5mg | $148 | 2024-03-01 | Buy |
Sigma-Aldrich | SML0136 | TGN-020 ≥98% (HPLC) | 51987-99-6 | 25mg | $588 | 2024-03-01 | Buy |
Tocris | 5425 | TGN020 ≥99%(HPLC) | 51987-99-6 | 50 | $487 | 2021-12-16 | Buy |
Tocris | 5425 | TGN020 ≥99%(HPLC) | 51987-99-6 | 10 | $115 | 2021-12-16 | Buy |
TRC | T344000 | N-(1,3,4-Thiadiazolyl)nicotinamide | 51987-99-6 | 25mg | $95 | 2021-12-16 | Buy |
N-(1,3,4-Thiadiazolyl)nicotinamide Chemical Properties,Uses,Production
Description
TGN-020 (51987-99-6) is an aquaporin 4 channel blocker, IC50?= 3.1 μM.1?Reduces ischemic cerebral edema in a mouse model of focal cerebral ischemia using MRI.2?TGN-020 increases regional cerebral blood flow as determined in wild-type and AQP-4 knockout mice.3? Reduces brain edema when administered after onset of ischemia in rat models.4
Chemical Properties
Off-White Solid
Uses
A thiadiazole derivative as antitumor agent.
Biochem/physiol Actions
TGN-020 is an inhibitor of Aquaporin 4 (AQP4), the most abundant water channel in brain. Aquaporins (AQPs) are water channels required for maintaining fluid homeostasis and enabling water movement across barrier membranes, but can enhance pathological cellular volume changes and cause edema in injury states. Pretreatment with the AQP4 inhibitor TGN-020 significantly reduced the volume of brain edema associated with ischemic injury in a mouse model of focal cerebral ischemia.
storage
Store at RT
References
1) Huber?et al. (2009), Identification of aquaporin 4 inhibitors using in vitro and in silico methods; Bioorg. Med. Chem.,?17?411 2) Igarashi?et al. (2011),?Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema; Neurol. Sci.,?32?113 3) Igarashi?et al. (2013),?Inhibition of aquaporin-4 significantly increases regional cerebral blood flow; Infect. Neuroreport,?24?324 4) Pirici?et al.?(2017),?Inhibition of Aquaporin-4 Improves the Outcome of Ischaemic Stroke and Modulates Brain Paravascular Drainage Pathways; Int. J. Mol. Sci.,?19?E46
N-(1,3,4-Thiadiazolyl)nicotinamide Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | 1015@dideu.com | China | 4088 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34571 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 | kathy@hbyinsheng.com | China | 3581 | 58 |