2-[(1-Methylpropyl)dithio]-1H-imidazole
![2-[(1-Methylpropyl)dithio]-1H-imidazole Structure](CAS/GIF/141400-58-0.gif)
- CAS No.
- 141400-58-0
- Chemical Name:
- 2-[(1-Methylpropyl)dithio]-1H-imidazole
- Synonyms
- PX 12;IV-2);CS-2384;PX-12 (PX12;2-(sec-Butyldisulfanyl)-1H-iMidazole;IV 2,inhibit,PX 12,PX-12,Inhibitor,IV2;2-[(1-Methylpropyl)dithio]-1H-imidazole;1H-Imidazole, 2-[(1-methylpropyl)dithio]-
- CBNumber:
- CB92518810
- Molecular Formula:
- C7H12N2S2
- Molecular Weight:
- 188.31
- MDL Number:
- MFCD18086851
- MOL File:
- 141400-58-0.mol
- MSDS File:
- SDS
| Boiling point | 330.0±25.0 °C(Predicted) |
|---|---|
| Density | 1.19±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >25mg/mL |
| pka | 11.88±0.10(Predicted) |
| form | powder |
| color | off-white to tan |
| FDA UNII | 8PQ9CZ8BTJ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29332900 | |||||||||
| NFPA 704 |
|
2-[(1-Methylpropyl)dithio]-1H-imidazole price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M5324 | PX 12 ≥98% (HPLC), powder | 141400-58-0 | 5mg | $150 | 2024-03-01 | Buy |
| Sigma-Aldrich | M5324 | PX 12 ≥98% (HPLC), powder | 141400-58-0 | 25mg | $601 | 2024-03-01 | Buy |
| Cayman Chemical | 14192 | PX 12 ≥98% | 141400-58-0 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 14192 | PX 12 ≥98% | 141400-58-0 | 5mg | $70 | 2024-03-01 | Buy |
| Cayman Chemical | 14192 | PX 12 ≥98% | 141400-58-0 | 10mg | $109 | 2024-03-01 | Buy |
2-[(1-Methylpropyl)dithio]-1H-imidazole Chemical Properties,Uses,Production
Uses
PX 12 is an irreversible and competitive inhibitor of thioredoxin-1.
Definition
ChEBI: 2-(butan-2-yldisulfanyl)-1H-imidazole is a member of imidazoles.
Biological Activity
px 12 is an inhibitor of thioredoxin-1 [1].thioredoxin-1 (trx-1) is a small redox protein with a conserved catalytic site and plays an important role in cells that includes the regulation of trans-activating activity and the dna binding of redox-sensitive transcription factors [1].in ht-29 human colon carcinoma cells and mcf-7 human breast cancer, px 12 prevented the hypoxia-induced increase in hif-1 protein. also, px 12 decreased inducible nitric oxide synthase, hif-1-trans-activating activity and vegf formation [2].in immunodeficient mice bearing ht-29 human colon xenografts, px 12 decreased the average tumor blood vessel permeability by 63% within 2 hours and returned to pretreatment values after 48 hours. px 12 reduced tumor-derived vegf and tumor after 24 hours. also, trx-1 showed a rapid decrease within 2 hours and maintained for 24 hours [1]. in mice bearing mcf-7 tumor xenografts, px 12 reduced hif-1ɑ and vegf protein levels [2]. in cancer patients, px-12 treatment significantly reduced the levels of trx-1 and vegf in plasma [3].
Biochem/physiol Actions
PX-12 inhibits the thioredoxin redox system and HIF-1a activity. PX 12 inhibits hypoxia-induced HIF-1a transcriptional activity (IC50 11 nM) and proliferation of HT29 and MCF-7 tumor cells (IC50 1.9 and 0.9 uM, respectively).
storage
Store at +4°C
References
[1]. jordan bf, runquist m, raghunand n, et al. the thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (px-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imaging. clin cancer res, 2005, 11(2 pt 1): 529-536.
[2]. welsh sj, williams rr, birmingham a, et al. the thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation. mol cancer ther, 2003, 2(3): 235-243.
[3]. baker af, dragovich t, tate wr, et al. the antitumor thioredoxin-1 inhibitor px-12 (1-methylpropyl 2-imidazolyl disulfide) decreases thioredoxin-1 and vegf levels in cancer patient plasma. j lab clin med, 2006, 147(2): 83-90.
2-[(1-Methylpropyl)dithio]-1H-imidazole Preparation Products And Raw materials
Raw materials
Preparation Products
2-[(1-Methylpropyl)dithio]-1H-imidazole Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
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| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
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| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |