ChemicalBook >> CAS DataBase List >>Azilsartan kaMedoxoMil

Azilsartan kaMedoxoMil

Azilsartan kaMedoxoMil structure

CAS No.: 863031-24-7

Chemical Name:: Azilsartan kaMedoxoMil

Synonyms: TAK 491 kamedoxomil;TAK-491 monopotassium;Azilsartan kaMedoxoMil;Azilsartan KaModoxoMil;Azilsartan KaMedoximil;Azilsartan Mehtyl ester;Azilsartan MedoxMil PotassuiM;Azilsartan Medoxomil Potassium;Azilsartan MedoxiMil PotassiuM;Azilsartan MedoxoMil PotassiuM salt

CBNumber:: CB92549391

Molecular Formula:: C30H25KN4O8

Molecular Weight:: 608.65

MDL Number:: MFCD24849277

MOL File:: 863031-24-7.mol

MSDS File:: SDS

Last updated:2023-05-18 11:31:11

Request For Quotation

Azilsartan kaMedoxoMil Properties

Melting point	193 - 195°C
storage temp.	Refrigerator, Under inert atmosphere
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
color	White to Off-White
FDA UNII	WEC6I2K1FC

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338

Azilsartan kaMedoxoMil price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	A965605	AzilsartanKamedoxomil(>90%)	863031-24-7	250mg	$425	2021-12-16	Buy
Usbiological	260001	Azilsartan medoxomil potassium	863031-24-7	250mg	$701	2021-12-16	Buy
Biorbyt Ltd	orb146200	Azilsartan kamedoxomil >98%	863031-24-7	250mg	$912.9	2021-12-16	Buy
ApexBio Technology	B1071	Azilsartanmedoxomilmonopotassium	863031-24-7	50mg	$1347	2021-12-16	Buy
Biorbyt Ltd	orb146200	Azilsartan kamedoxomil >98%	863031-24-7	1g	$1802	2021-12-16	Buy

Product number	Packaging	Price	Buy
A965605	250mg	$425	Buy
260001	250mg	$701	Buy
orb146200	250mg	$912.9	Buy
B1071	50mg	$1347	Buy
orb146200	1g	$1802	Buy

Azilsartan kaMedoxoMil Chemical Properties,Uses,Production

Uses

Azilsartan Kamedoxomil is an angiotensin II receptor blocker.

Definition

ChEBI: An organic potassium salt that is the monopotassium salt of azilsartan medoxomil. A prodrug for azilsartan, it is used for treatment of hypertension.

Clinical Use

Azilsartan kamedoxomil, developed by Takeda Pharmaceuticals, was approved for the treatment of hypertension and launched in the U.S. under the brand name Edarbi. Edarbi is a prodrug that undergoes rapid hydrolysis to liberate azilsartan, the active ingredient (TAK-536, 39). As the 8th angiotensin receptor blocker (ARB) to enter the world market, azilsartan kamedoxomil can function as monotherapy or in combination with other antihypertensive agents. In several clinical studies, monotherapeutic azilsartan kamedoxomil showed superior antihypertensive activity and a favorable safety/tolerability profile in patients compared with other established therapeutics, including valsartan, olmesartan medoxomil, candesartan, and telmisartan.In late 2011,Takeda announced that FDA also approved the fixed-dose combination tablet of azilsartan kamedoxomil with chlorthalidone under the trade name of Edarbyclor.

Synthesis

Based on the synthesis of azilsartan, the process-scale approach to azilsartan kamedoxomil is described in the scheme. The synthesis started with commercially available methyl 2-[(tert-butoxycarbonyl)amino]-3-nitrobenzoate (30), which can also be prepared by several different routes.41,42 Alkylation of 30 with diaryl bromide 31 gave benzylamine 32 in 78% yield, which was followed by deprotection with 30% ethanolic HCl and alkalinization to produce amine 33 in 77% yield. The nitro group within 33 was reduced with hydrazine hydrate and a catalytic amount of ferric chloride to afford 2,3-diaminobenzoate 34 in 64% yield. Ring formation was achieved by treatment of 34 with tetraethoxymethane and acetic acid to produce benzimidazole 35 in 91% yield.37 The addition of hydroxylamine to the cyano group of 35 provided amidoxime 36 in 55% yield, which underwent immediate cyclization upon treatment with 2-ethylhexyl chloroformate 37 in refluxing xylenes to give oxadiazolone 38 in 52% yield. Hydrolysis of 38 gave azilsartan (39, TAK-536) in 94% yield. In the presence of perchlorobenzoyl chloride 40 and triethylamine, carboxylic acid 39 was converted to the mixed acid anhydride intermediate, which when condensed with alcohol 41 furnished benzoate 42 in 50% yield. Salt preparation of 42 was accomplished with potassium 2-ethylhexyl carboxylate 43 affording azilsartan kamedoxomil (V) in 63% yield.

Synthesis_863031-24-7

Azilsartan kaMedoxoMil Preparation Products And Raw materials

Raw materials

Preparation Products

Azilsartan kaMedoxoMil Suppliers

Global( 164)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
HubeiwidelychemicaltechnologyCo.,Ltd	18627774460	faith@widelychemical.com	CHINA	742	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10297	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12468	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
HubeiwidelychemicaltechnologyCo.,Ltd	58
Chongqing Chemdad Co., Ltd	58
Fuxin Pharmaceutical	58
Zhengzhou Alfa Chemical Co.,Ltd	58
SIMAGCHEM CORP	58
AFINE CHEMICALS LIMITED	58
Dayang Chem (Hangzhou) Co.,Ltd.	58

View Lastest Price from Azilsartan kaMedoxoMil manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2022-09-15	azilsartan kamedoxomil 863031-24-7	US $40.00 / kg	1kg	99%	Ex 20 tons	Hebei Anda Technology Co., LTD
	2019-07-06	Azilsartan kaMedoxoMil 863031-24-7	US $1.00 / kg	1kg	98%	1000KG	Career Henan Chemical Co

azilsartan kamedoxomil
863031-24-7
US $40.00 / kg
99%
Hebei Anda Technology Co., LTD

Azilsartan kaMedoxoMil
863031-24-7
US $1.00 / kg
98%
Career Henan Chemical Co

863031-24-7(Azilsartan kaMedoxoMil)Related Search:

1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, Methyl ester (Z)-Methyl 2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d] iMidazole-4-carboxylate Azilsartan Medoxomil Azilsartan

Azilsartan kaMedoxoMil 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester potassium salt Azilsartan MedoxoMil PotassiuM salt Azilsartan MedoxoMil (MonopotassiuM salt) Azilsartan MedoxoMil (MonopotassiuM) Azilsartan MedoxiMil PotassiuM Azilsartan KaModoxoMil Azilsartan kaMedoxoMil (with 5 ints.) Azilsartan MedoxMil PotassuiM 1H-BenziMidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl] -2-ethoxy-, (5-Methyl-2-oxo-1,3-dioxol-4-yl)Methyl ester, potassiuM salt Azilsartan Medoxomil Potassium Azilsartan Mehtyl ester Azilsartan Impurity 50 Potassium Salt Azilsartan medoxomil monopotassium (TAK 491) Azilsartan KaMedoximil Azilsartan Medoxomil Potassium Crude Azilsartan Impurity 45 Potassium Salt (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate, potassium salt TAK 491 kamedoxomil TAK-491 monopotassium Azilsartan Impurity 60 Potassium Salt 863031-24-7 C30H23KN4O8 C30H23N4O8K Azilsartan Kamedoxomil 863031-24-7