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Azilsartan

Azilsartan
Azilsartan structure
CAS No.
147403-03-0
Chemical Name:
Azilsartan
Synonyms
Tak 536;AZILSARTAN;AZATMint-E;Azilsartan API;Unii-F9nux55p23;Azilsartan (TAK-536);Azilsartan metabolite MI D4;Azilsartan metabolite MII-D4;AzilsartanMedoxoMilInterMediates-3;2-Ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid
CBNumber:
CB21090899
Molecular Formula:
C25H20N4O5
Formula Weight:
456.45
MOL File:
147403-03-0.mol

Azilsartan Properties

Density 
1.42
storage temp. 
2-8°C
solubility 
DMSO: soluble15mg/mL (clear solution)
form 
powder
color 
white to beige
InChIKey
KGSXMPPBFPAXLY-UHFFFAOYSA-N

SAFETY

WGK Germany  3

Azilsartan price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0432 Azilsartan ≥98% (HPLC) 147403-03-0 10mg $76.7 2018-11-20 Buy
Sigma-Aldrich SML0432 Azilsartan ≥98% (HPLC) 147403-03-0 50mg $297 2018-11-20 Buy
TCI Chemical A2601 Azilsartan >98.0%(HPLC)(T) 147403-03-0 200mg $159 2018-11-22 Buy
TCI Chemical A2601 Azilsartan >98.0%(HPLC)(T) 147403-03-0 1g $555 2018-11-22 Buy

Azilsartan Chemical Properties,Uses,Production

Chemical Properties

White to Off-White Solid

Uses

Azilsartan is an analgesic and antiinflammatory drugs containing angiotensin II antagonists.

Uses

Azilsartan is an angiotensin II type 1 (AT1) receptor antagonist with IC50 of 2.6 nM

Definition

ChEBI: A benzimidazolecarboxylic acid that is benzimidazole-7-carboxylic acid substituted at position 2 by a methoxy group and at position 1 by a 2'-[(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl group. Used (as the prodrug, azilsartan medoxomil) f r treatment of hypertension.

Enzyme inhibitor

This angiotensin II receptor antagonist and its membrane-permeant pro- drug (FWdrug = 456.45 g/mol; CAS 147403-03-0; FWpro-drug = 568.53 g/mol; CAS 863031-21-4), also named TAK-536 (drug) and TAK-491 (pro-drug), Edarbi?, and (5-methyl-2-oxo-1,3-dioxol-4-yl) methyl 2-ethoxy-1- ([2'- (5- oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl) biphenyl-4-yl]methyl) -1H-benzimid- azole-7-carboxylate, lowers blood pressure by blocking the binding of the vasopressor hormone, angiotensin II, to the angiotensin Type-1 receptor (or AT1-receptor), IC50 = 45 nM. Blocking of AT1 receptors reduces blood pressure by promoting vasodilation, decreasing vasopressin secretion, and reducing aldosterone production/secretion. The pro-drug is hydrolyzed to the active moiety in the gastrointestinal (GI) tract during the absorption phase. The estimated absolute bioavailability of azilsartan is 60%. Absorption is unaffected by food, and peak plasma concentrations are reached within several hours before its eventual deactivation by cytochrome P450 (CYP2C9), biological t1/2 ≈ 11 hours. The U.S. FDA approved Edarbi for the treatment of high blood pressure in adults in February, 2011.

Azilsartan Preparation Products And Raw materials

Raw materials

Preparation Products


Azilsartan Suppliers

Global( 231)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Jiangsu Zhongbang Pharmaceutical Co., Ltd.
025-87151996
025-87151996 zbsales@chinaredsun.com CHINA 32 55
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 224 58
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21956 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1529 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20676 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24196 60
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 3911 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 25796 58
Jinan Shengqi pharmaceutical Co,Ltd
86+15552594168
christine@shengqipharm.com CHINA 554 58

View Lastest Price from Azilsartan manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-04 Azilsartan
147403-03-0
US $100.00 / KG 1KG 95% 1000KG career henan chemical co

147403-03-0(Azilsartan)Related Search:


  • AZILSARTAN
  • 2-Ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid Azilsartan
  • 2-Ethoxy-1-{[2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylic acid
  • 2-ethoxy -1- {[2'-(5-oxo-4,5-dihydro -1,2,4 -oxadiazol-3-yl) biphenyl-4-yl ] methyl} -1H –benzimi[d]dazole-7-carboxylic acid
  • 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro- 1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylic acid
  • AZATMint-E
  • 2-Ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid
  • Tak 536
  • Unii-F9nux55p23
  • 2-ethoxy-3-((2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)Methyl)-3H-benzo[d]iMidazole-4-carboxylic acid
  • Azilsartan 2-Ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]Methyl]benziMidazole-7-carboxylic acid
  • 1-[[2'-(2,5-Dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]Methyl]-2-ethoxy-1H-benziMidazole-7-carboxylic Acid
  • Azilsartan (TAK-536)
  • AzilsartanMedoxoMilInterMediates-3
  • 2. 2-Ethoxy-1-[[2'-(4,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]Methyl]benziMidazole-7-carboxylic acid
  • Azilsartan API
  • 2-Ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl) biphenyl-4-yl]Methyl }-1H-benzo -[d]iMidazole-7- carboxylic acid
  • 1H-Benzimidazole-7-carboxylic acid, 1-[[2'-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl]-2-ethoxy-
  • -
  • 147403-03-0
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Intermediates
  • Azilsartan metabolite MI D4
  • Azilsartan metabolite MII-D4
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