Nortadalafil
- CAS No.
- 171596-36-4
- Chemical Name:
- Nortadalafil
- Synonyms
- Nortadalafil;DeMethyltadalafil;N-demethyltadalafil;Tadalafil IMpurity J;N-DesMethyl Tadalafil;Tadalafil Impurity 21;Demethyltadalafil impurity;Tadalafil IMpurity:IMpurity C;Tadanafil N-desmethyl impurity;Nortadalafil/Demethyl Tadalafil
- CBNumber:
- CB92549609
- Molecular Formula:
- C21H17N3O4
- Molecular Weight:
- 375.38
- MDL Number:
- MFCD19443817
- MOL File:
- 171596-36-4.mol
- MSDS File:
- SDS
Melting point | 285-290℃ (methanol ) |
---|---|
Boiling point | 718.6±60.0 °C(Predicted) |
Density | 1.55±0.1 g/cm3(Predicted) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
form | Solid |
pka | 13.53±0.40(Predicted) |
color | White to Pale Yellow |
FDA UNII | 5W59DMB3LD |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS05,GHS07,GHS09 |
---|---|
Signal word | Danger |
Hazard statements | H302+H312-H314-H317-H410 |
Precautionary statements | P501-P273-P272-P260-P270-P264-P280-P391-P362+P364-P303+P361+P353-P333+P313-P301+P330+P331-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P405 |
Nortadalafil price More Price(33)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | D293800 | N-DesmethylTadalafil | 171596-36-4 | 5mg | $185 | 2021-12-16 | Buy |
ApexBio Technology | A3665 | Nortadalafil | 171596-36-4 | 5mg | $213 | 2021-12-16 | Buy |
Biosynth Carbosynth | FD21326 | N-Desmethyl tadalafil | 171596-36-4 | 5mg | $285 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0010360 | NORTADALAFIL 95.00% | 171596-36-4 | 5MG | $322.3 | 2021-12-16 | Buy |
ApexBio Technology | A3665 | Nortadalafil | 171596-36-4 | 10mg | $331 | 2021-12-16 | Buy |
Nortadalafil Chemical Properties,Uses,Production
Uses
A N-desmethyl analogue of the human PDE5 inhibitor Tadalafil (T004500). A potential antiplasmodial drug.
Biological Activity
the cgmp-specific pde5 is the major pde isozyme in the corpus cavernosum, and controls penile erection. the pde5 inhibitors used in the clinic amplify the no-ccmp pathway and enhance the normal process leading to penile erection.nortadalafil is demethyl tadalafil, which is a pde5 inhibitor currently marketed in pill form for treating erectile dysfunction under the name cialis and for the treatment of pulmonary arterial hypertension under the name adcirca.
in vitro
tadalafil has been identified as a highly potent pde5 inhibitor (ic50 = 5 nm) with high selectivity for pde5 vs pde1-4 and pde6. it displays 85-fold greater selectivity vs pde6 than sildenafil [1].
in vivo
tadalafil showed profound and long-lasting blood pressure lowering activity (30 mmhg/>7 h) in the spontaneously hypertensive rat model after oral administration (5 mg/kg) [1].
target
PDE5
IC 50
n/a for nortadalafil; 5 nm for tadalafil
References
[1] daugan a, grondin p, ruault c, le monnier de gouville ac, coste h, linget jm, kirilovsky j, hyafil f, labaudinière r. the discovery of tadalafil: a novel and highly selective pde5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues. j med chem. 2003;46(21):4533-42.
[2] porst h, hell-momeni k, büttner h. chronic pde-5 inhibition in patients with erectile dysfunction - a treatment approach using tadalafil once-daily. expert opin pharmacother. 2012 jul;13(10):1481-94. doi: 10.1517/14656566.2012.693162.
Nortadalafil Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52861 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9285 | 55 |
Jinan Jianfeng Chemical Co., Ltd | +8615562555968 | info@pharmachemm.com | China | 247 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Jinan Gongchuang Pharmaceutical Technology Co., Ltd. | 13287783460 | 3166282224@qq.com | CHINA | 10 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14335 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29821 | 58 |
SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
View Lastest Price from Nortadalafil manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2021-10-29 | Nortadalafil
171596-36-4
|
US $0.00 / ASSAYS | 100ASSAYS | 99.99 | 10000 | Jiangsu Monade Biological Technology Co., Ltd. | ||
2020-01-03 | Nortadalafil
171596-36-4
|
US $7.00 / KG | 1KG | 99% | 100kg | Career Henan Chemical Co |
- Nortadalafil
171596-36-4
- US $0.00 / ASSAYS
- 99.99
- Jiangsu Monade Biological Technology Co., Ltd.
- Nortadalafil
171596-36-4
- US $7.00 / KG
- 99%
- Career Henan Chemical Co
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