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D(+)-Tryptophan

Description Description Characteristics and Functions Project Standards Application References References
D(+)-Tryptophan
D(+)-Tryptophan structure
CAS No.
153-94-6
Chemical Name:
D(+)-Tryptophan
Synonyms
WV;LTR;D-TRP;TRP-01;D-Trp-OH;(S)-alph;NSC 97942;H-D-TRP-OH;H-D-TYP-OH;D-TRYTOPHAN
CBNumber:
CB2280905
Molecular Formula:
C11H12N2O2
Formula Weight:
204.23
MOL File:
153-94-6.mol

D(+)-Tryptophan Properties

Melting point:
282-285 °C (dec.)(lit.)
alpha 
31.5 º (c=1, H2O 24 ºC)
Boiling point:
342.72°C (rough estimate)
Density 
1.1754 (rough estimate)
refractive index 
31 ° (C=1, H2O)
storage temp. 
Store at RT.
form 
Powder
color 
White to slightly yellow
Water Solubility 
11 g/L (20 ºC)
BRN 
86198
Stability:
Stable. Incompatible with oxidizing agents.
InChIKey
QIVBCDIJIAJPQS-SECBINFHSA-N
CAS DataBase Reference
153-94-6(CAS DataBase Reference)
EPA Substance Registry System
D-Tryptophan(153-94-6)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi
Risk Statements  36/37/38-41-37/38-22
Safety Statements  24/25-36/37/39-36-26
WGK Germany  3
RTECS  YN6129000
8
TSCA  Yes
HazardClass  IRRITANT
HS Code  29339990

D(+)-Tryptophan price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T9753 D-Tryptophan ≥98.0% (HPLC) 153-94-6 1g $16.7 2018-11-13 Buy
Sigma-Aldrich T9753 D-Tryptophan ≥98.0% (HPLC) 153-94-6 5g $42.8 2018-11-13 Buy
TCI Chemical T0539 D-Tryptophan >98.0%(HPLC)(T) 153-94-6 5g $38 2018-11-22 Buy
TCI Chemical T0539 D-Tryptophan >98.0%(HPLC)(T) 153-94-6 25g $114 2018-11-22 Buy
Alfa Aesar A18426 D-Tryptophan, 99% 153-94-6 25g $103 2018-11-13 Buy

D(+)-Tryptophan Chemical Properties,Uses,Production

Description

D(+)-tryptophan is the D-form (non-proteinogenic form) of the amino acid tryptophan. It can be used for Human embryonic kidney cell (HEK-293, ATCC: CRL-1573) culture. It is also a sweetener used to study the release of incretins from enteroendocrine cells triggered by sugar but not by sweeteners.

Description

D-tryptophan (Full name D (+)-Tryptophan) is a white to pale yellow or white crystalline powder at room temperature, odorless or slight odor, slightly sweet taste. Solubility in water is 1.14 g (25 ℃), soluble in dilute acid and alkali, stable in alkali, decomposed in strong acid, slightly soluble in ethanol, not soluble in chloroform, ethyl ether. It plays an important role for human and animal growth and development, metabolism, known as the second essential amino acids. They are almost identical with L-type and physical and chemical properties, and only the optical activity is opposite. But their distribution, function and coenzyme have diversity. Its melting point is very high, generally above 200 degrees. It can dissolve in water, and in the near UV region it has the ability to absorb light.
Tryptophan is one of the 20 standard amino acids, as well as an essential amino acid in the human diet. It is encoded in the standard genetic code as the codon UGG. the D-stereoisomer is occasionally found in naturally produced peptides (for example, the marine venom peptide contryphan). The distinguishing structural characteristic of tryptophan is that it contains an indole functional group. It is an essential amino acid as defined by its growth effects on rats.

Characteristics and Functions

D-tryptophan amino acid, as a non-reactive protein, has special physiological properties. It can be used as a non-nutritive sweeteners, feed additive, plant growth agents in food feed industry and agriculture. In the pharmaceutical industry, it mainly used for the synthesis of various polypeptides, instead of L-tryptophan peptide drug for half-life extending and reduce the side effects, but it will not resistant to the front body, and it will become important enzyme inhibitor. It can also improve the body's immunity, delayed allergic reactions. Most peptide antibiotic can resistant gram-positive bacteria, Gram-negative bacteria and some, such as Pseudomonas aeruginosa, mycobacteria, fungi, bacteria, pathogens and tumor cells, which have better inhibit and kill ability.
D-tryptophan can be used for the synthetic of semi-synthetic antibiotics, for which pharmacological plays an important role for the side chain. The peptide bond is difficult to be β-lactam enzyme action, thus high stability, and has broad antibacterial spectrum, toxicity, hypoallergenic, rapid absorption, high blood concentrations of the drug long duration.

Project Standards

Appearance  white or slightly yellow crystalline powder
Content 99.0%~101.0%
Specific rotation [α] D20 + 30.5 °~+ 32.5 °
Transmittance ≥95.0%
Acidity PH 5.5~6.4
Loss on drying ≤0.2%
Residue on ignition ≤0.1%
Chloride [Cl-] ≤0.02%
Sulphate [SO42-] ≤0.02%
Ammonium [NH4 +] ≤0.02%
Heavy metals [Pb] ≤10ppm
Ferric [Fe] ≤10ppm
Arsenic salt [As2O3] ≤1ppm
Other amino acids compliance

Application

An important nutrient, niacin is used as the control agent Medicine
Production method: D-tryptophan as raw material, chloroacetic anhydride was added under cooling state after polishing sulfuric acid in ice water, filtered and recrystallized from water, and finally treatment with carboxypeptidase trypsin to remove L-type, acidified with acetic acid, ethanol recrystallization refining.

References

https://pubchem.ncbi.nlm.nih.gov/compound/D-Tryptophan#section=Top

References

Fujita, Yukihiro, et al. "Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo." American Journal of Physiology Endocrinology & Metabolism 296.3(2009):E473.
Bacchus, W, W. Weber, and M. Fussenegger. "Increasing the dynamic control space of mammalian transcription devices by combinatorial assembly of homologous regulatory elements from different bacterial species." Metabolic Engineering 15.1(2013):144.

Chemical Properties

white powder

Uses

An essential amino acid found in naturally produced pedtides. Unlike its stereoisomer, L-tryptophan, it is not used in structural or enzyme proteins.

Uses

An essential amino acid found in naturally produced peptides. Unlike its stereoisomer, L-tryptophan, it is not used in structural or enzyme proteins.

Definition

ChEBI: The D-enantiomer of tryptophan.

General Description

White solid.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Fire Hazard

Flash point data are not available for D(+)-Tryptophan, but D(+)-Tryptophan is probably combustible.

D(+)-Tryptophan Preparation Products And Raw materials

Raw materials

Preparation Products


D(+)-Tryptophan Suppliers

Global( 425)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Taizhou Tianhong Biochemistry Technology Co., Ltd.
0523-86132544
0523-86201489 sales@thbiochem.com CHINA 217 60
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21701 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Shanghai Yingrui Biopharma Co., Ltd.
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+86-21-34979012 sales03@shyrchem.com CHINA 661 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29979 58
Zhejiang ZETian Fine Chemicals Co. LTD
+86-18957127338
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View Lastest Price from D(+)-Tryptophan manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-30 D(+)-Tryptophan
153-94-6
US $100.00 / KG 1KG 99% Customized career henan chemical co

D(+)-Tryptophan Spectrum


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