NSC 33994
- CAS No.
- 82058-16-0
- Chemical Name:
- NSC 33994
- Synonyms
- G6;NSC 33994;4,4′-(3E)-Hex-3-ene-3,4-diylbis{2-[(diethylamino)methyl]phenol};(E)-4,4'-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylaMino)Methyl]phenol;4,4'-[(1E)-1,2-Diethyl-1,2-ethenediyl]bis[2-[(diethylaMino)Methyl]phenol;Phenol, 4,4'-[(1E)-1,2-diethyl-1,2-ethenediyl]bis[2-[(diethylamino)methyl]-;(E)-4,4′-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]-phenol (9CI)
- CBNumber:
- CB92550801
- Molecular Formula:
- C28H42N2O2
- Molecular Weight:
- 438.65
- MDL Number:
- MFCD20488055
- MOL File:
- 82058-16-0.mol
| Boiling point | 524.7±45.0 °C(Predicted) |
|---|---|
| Density | 1.040±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥25mg/mL |
| form | powder |
| pka | 9.20±0.50(Predicted) |
| color | white to tan |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
NSC 33994 price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0069 | NSC 33994 ≥98% (HPLC) | 82058-16-0 | 5mg | $119 | 2022-05-15 | Buy |
| Tocris | 4338 | NSC 33994 ≥98%(HPLC) | 82058-16-0 | 10 | $189 | 2021-12-16 | Buy |
| Tocris | 4338 | NSC 33994 ≥98%(HPLC) | 82058-16-0 | 50 | $744 | 2021-12-16 | Buy |
| TRC | N900300 | NSC 33994 | 82058-16-0 | 500mg | $1145 | 2021-12-16 | Buy |
| Usbiological | 018611 | NSC 33994 | 82058-16-0 | 50mg | $432 | 2021-12-16 | Buy |
NSC 33994 Chemical Properties,Uses,Production
Description
NSC-33994 (82058-16-0) is a remarkably potent and selective JAK2 inhibitor (IC50 = 60 nM). Displays no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.1?Suppresses JAK2-V617F-mediated human pathological cell growth?in vitro?and?in vivo2?and is concomitant with the disruption of intracellular vimentin filaments3. NSC-33994 reduces the tumorigenic potential of T98G glioblastoma cells?in vitro?and?in vivo.4
Uses
NSC-33994 is novel inhibitor of JAK2 tyrosine kinase (Janus kinase 2 ). Janus kinase 2 (JAK2) plays a crucial role in the pathomechanism of myeloproliferative disorders and hematological malignancies.
storage
-20°C
References
1) Kiss?et al. (2009),?Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening; Bioorg. Med. Chem. Lett.,?19?3598 2) Kirabo?et al. (2011),?The stilbenoid tyrosine kinase inhibitor, G6, suppresses Jak2-V617F-mediated human pathological cell growth in vitro and in vivo; J. Biol. Chem.,?286?4280 3) Majumder?et al. (2011),?Cell death induced by the Jak2 inhibitor, G6, correlates with cleavage of vimentin filaments; Biochemistry,?50?7774 4) Baskin?et al. (2014),?The Jak2 small molecule inhibitor, G6, reduces the tumorigenic potential of T98G glioblastoma cells in vitro and in vivo; PLoS One,?9(8)?e105568
NSC 33994 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55717 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |